Sporadic periventricular nodular heterotopia: Classification, phenotype and correlation with Filamin A mutations

Heterotopia is defined by the presence of groups of normal neurons in an inappropriate location, which results from a primary failure of neuronal migration, including periventricular, subcortical and leptomeningeal glioneuronal varieties (Barkovich et al., 2001; Barkovich et al., 2005; Barkovich et al., 2012; Guerrini and Barba, 2010). The most common clinical manifestations of heterotopia are epileptic seizures, mainly resistant focal seizures, neurological deficits, systemic malformations and developmental delays (Barkovich et al., 2012; Guerrini and Parrini, 2010).

Source: Epilepsy Research - April 3, 2017 Category: Neurology Authors: Wenyu Liu, Bo Yan, Dongmei An, Jiahe Xiao, Fayun Hu, Dong Zhou Source Type: research