Compromised GABAergic inhibition contributes to tumor-associated epilepsy

Gliomas are the most common form of primary brain tumor and frequently present with seizures (Iuchi et al., 2015; Kerkhof and Vecht, 2013; van Breemen et al., 2007). The tumor mass itself does not show epileptiform activity, but rather seizures originate from neurons in the peritumoral region (Kohling et al., 2006; Patt et al., 2000; Senner et al., 2003). The standard treatment for glioma involves surgical resection; however, tumor associated epilepsy often persists following glioma removal (Iuchi et al., 2015).

Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Georgina MacKenzie, Kate K. O ’Toole, Jamie Maguire Source Type: research