Investigation of mechanisms of vagus nerve stimulation for seizure using finite element modeling

Vagus Nerve Stimulation (VNS) was FDA approved nearly 20 years ago in 1997, implanted in over 65,000 patients and yet its mechanisms of action in treating epileptic seizures remain unclear. While responder rates are over 50% for the 30 –40% of patients who are resistant to anti-seizure medications, most responders do not become seizure-free, but rather have the severity and frequency of seizures reduced by approximately 40–50% on average (Amar et al., 2009; Wu and Sharan, 2013).

Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Jeffrey E. Arle, Kristen W. Carlson, Longzhi Mei Source Type: research