Maximal/Exhaustive Treadmill Test Features in Patients with Temporal Lobe Epilepsy: Search for Sudden Unexpected Death Biomarkers

Epilepsy is one of the most important neurological diseases in clinical practice, being the second most common neurological disease in primary care. All over the world, around 65 million individuals suffer from epilepsy (Thurman et al., 2011) and patients with epilepsy (PWE) have a 20 to 40-fold increased risk for sudden death (Ficker et al., 1998; Mohanraj et al., 2006). In fact, Sudden Unexpected Death in Epilepsy (SUDEP) is responsible for 17 to 38% of deaths in PWE. SUDEP has been defined as the sudden, unexpected, witnessed or unwitnessed, non-traumatic, and non-drowning death in PWE, with or without evidence for a seizure, with exclusion of documented status epilepticus, and when post-mortem examination does not reveal a structural or toxicological cause for death (Nashef, 2012, 1997).

Source: Epilepsy Research - April 24, 2017 Category: Neurology Authors: Guilherme L. Fialho, Arthur G. Pagani, Roger Walz, Peter Wolf, Katia Lin Source Type: research