Prolonged epileptiform EEG runs are associated with persistent seizures in juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy (JME) is the most common form of idiopathic generalized (genetic) epilepsy (Syvertsen et al., 2017). Seizure onset usually occurs around puberty with early morning myoclonic jerks. The majority of patients develop generalized tonic-clonic seizures and 20-40% has absence seizures (Commission, 1989; Genton et al., 2013; Janz, 1989; Kasteleijn- Nolst Trenit é et al., 2013). EEG is the most useful supplementary diagnostic method. Valproate is effective in the majority of patients (Gesche et al., 2017; Penry et al., 1989), but reproductive toxicity limits its use in women.

Source: Epilepsy Research - May 8, 2017 Category: Neurology Authors: Vibeke Arntsen, Trond Sand, Marte R. Syvertsen, Eylert Brodtkorb Source Type: research