Continuous ictal discharges with high frequency oscillations confined to the non-sclerotic hippocampus in an epileptic patient with radiation-induced cavernoma in the lateral temporal lobe.
Conclusion: iECoG and HFO analysis revealed high epileptogenicity in the non-sclerotic hippocampus of this patient. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - January 23, 2019 Category: Neurology Source Type: research
Preserved evoked conscious perception of phosphenes with direct stimulation of deafferented primary visual cortex
We describe a patient who developed a quadrantopsia and epilepsy after an arteriovenous malformation hemorrhage. Thirty years later, he underwent placement of subdural electrodes for seizure mapping. Phosphenes were elicited in the blind right visual field with stimulation of occipital cortex. This case demonstrates that visual cortex may retain functional organization after a partial subcortical visual pathway injury. This persistent conscious mapping suggests that disconnected visual cortex could serve as a region for interfacing with neural prosthetic devices for acquired blindness. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - January 15, 2019 Category: Neurology Source Type: research
Perampanel in lissencephaly-associated epilepsy
Publication date: Available online 11 January 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Satoru Ikemoto, Shin-ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Reiko KoichiharaAbstractWe retrospectively investigated whether perampanel (PER) could serve as an alternative for treating drug-resistant seizures in lissencephaly. We investigated the following data: age at onset of epilepsy, age at start of PER, etiology, brain MRI findings, seizure type, seizure frequency, adverse effects, and concomitant anti-epileptic drugs. There were 5 patients with lissencephaly, including 2 with Miller-Dieker syndrome. Four out of fi...
Source: Epilepsy and Behavior Case Reports - January 12, 2019 Category: Neurology Source Type: research
A case of auditory disturbance caused by Lacosamide
We report a case of auditory disturbance in an adult female that developed after starting lacosamide treatment for epilepsy. While carbamazepine is known to change auditory pitch perception in some patients, that has not been previously reported as a side effect of lacosamide administration. In this first description of pitch perception deficit associated with lacosamide, we outline features seen in our patient and compare our findings with those of previous reports describing carbamazepine-associated auditory disturbance. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - January 12, 2019 Category: Neurology Source Type: research
Implementation of ketogenic diet in children with drug-resistant epilepsy in a medium resources setting: Egyptian experience
ConclusionThe current study shows that the ketogenic diet could be implemented in medium resources countries and should be included in the management of children with intractable epilepsy. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - December 29, 2018 Category: Neurology Source Type: research
Are there mortality risks for patients with epilepsy who use cannabis treatments as monotherapy?
Publication date: Available online 3 December 2018Source: Epilepsy & Behavior Case ReportsAuthor(s): Devon M. Kollmyer, Kyla E. Wright, Nicole M. Warner, Michael J. DohertyAbstractMortalities associated with cannabis used for treatment of epilepsy are not well documented. We discuss two mortalities in light of their epilepsy histories and their self-determined therapies with cannabis (SDTC). One patient had probable sudden unexpected death in epilepsy, the second due to seizure-associated drowning. Both prioritized SDTC over conventional anti-seizure medications. Where recreational cannabis is legal, decisions to use canna...
Source: Epilepsy and Behavior Case Reports - December 3, 2018 Category: Neurology Source Type: research
Adult-onset Rasmussen's syndrome with associated cortical dysplasia
We describe a 23 year old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with drug-resistant right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapies. Stereotactic-EEG evaluation demonstrated multifocal independent ictal patterns in the right hemisphere. Rasmussen...
Source: Epilepsy and Behavior Case Reports - November 29, 2018 Category: Neurology Source Type: research
Nonconvulsive status epilepticus secondary to acute Porphyria crisis
We report a unique presentation of NCSE, which resolved after administering levetiracetam in a patient with variegate porphyria, without a known seizure disorder. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - November 29, 2018 Category: Neurology Source Type: research
A case of ictal burst-suppression
Publication date: Available online 26 November 2018Source: Epilepsy & Behavior Case ReportsAuthor(s): Pegah Afra, Verena Clarissa Samara, Lilly Fagatele, Bola AdamolekunAbstract“Burst-suppression” pattern consists of complete attenuation of background between bursts of mixed frequencies, variable morphology and waveforms. It is a subgroup of periodic patterns seen in severe cerebral damage, anesthesia or prematurity. Here, we present a 46 year-old-woman with post-anoxic encephalopathy on cooling protocol with two electrographically similar patterns of burst-suppression (one with clinical ictal correlate of isolated e...
Source: Epilepsy and Behavior Case Reports - November 26, 2018 Category: Neurology Source Type: research
Ictal asystole with isolated syncope: A case report and literature review
We report a case of a previously healthy male who developed recurrent episodes of syncope with postictal confusion and was later diagnosed with temporal seizures. The patient was successfully treated with anticonvulsants and the placement of a cardiac pacemaker. In a systematic review of literature, we summarize the clinical characteristics of patients with ictal asystole and isolated syncope. Seizures should be considered in patients with syncope of uncertain etiology. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - November 25, 2018 Category: Neurology Source Type: research
Implementation of ketogenic diet in children with intractable epilepsy in a medium resources setting: A single institutional experience
Publication date: Available online 23 November 2018Source: Epilepsy & Behavior Case ReportsAuthor(s): Mary Gerges, Laila Selim, Marian Girgis, Amr El Ghannam, Hadeer Abdelghaffar, Ahmed El-Ayadi (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - November 24, 2018 Category: Neurology Source Type: research
Longitudinal brain functional and structural connectivity changes after hemispherotomy in two pediatric patients with medically intractable epilepsy
Publication date: Available online 24 November 2018Source: Epilepsy & Behavior Case ReportsAuthor(s): Yongxin Li, Ya Wang, Zhen Tan, Qian Chen, Wenhua HuangAbstractThe main focus of the present study was to explore the longitudinal changes in the brain executive control system and default mode network after hemispherotomy. Resting-state functional magnetic resonance imaging and diffusion tensor imaging were collected in two children with medically intractable epilepsy underwent hemispherotomy. Two patients with different curative effect showed different trajectories of brain connevtivity after surgery. The failed hemispher...
Source: Epilepsy and Behavior Case Reports - November 24, 2018 Category: Neurology Source Type: research
Ictal vomiting after cerebellar hemorrhage: A case report
In conclusion, physicians must be aware that vomiting may rarely occur as a sign of seizures and status epilepticus. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - November 8, 2018 Category: Neurology Source Type: research
Valproic acid as a monotherapy in drug-resistant methyl-CpG-binding protein 2 gene (MECP2) duplication-related epilepsy
We present the case of an eleven-year old male with MECP2 duplication and epilepsy, who was resistant to polytherapy. The patient responded well to valproic acid (VPA) initially and upon re-challenge. This case report provides evidence for the use of VPA as an initial monotherapy for treatment of drug-resistant MECP2 duplication-related epilepsy. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - November 6, 2018 Category: Neurology Source Type: research
Epilepsy phenotype in patients with Xp22.31 microduplication
We describe a family in which mother and two children have Xp22.31 microduplication associated with different forms of epilepsy and epileptiform EEG abnormalities. The proband had benign epilepsy with centrotemporal spikes with dysgraphia and dyscalculia (IQ 72), the sister had juvenile myoclonic epilepsy, and both had bilateral talipes anomalies. The mother, carrier of the microduplication, was asymptomatic. The asymptomatic father did not present microduplication. These data contribute to delineate the phenotype associated with Xp22.31 microduplication and suggest its pathogenic role, probably additive, also for the epil...
Source: Epilepsy and Behavior Case Reports - November 6, 2018 Category: Neurology Source Type: research
