Longitudinal brain functional and structural connectivity changes after hemispherotomy in two pediatric patients with medically intractable epilepsy

Publication date: Available online 24 November 2018Source: Epilepsy & Behavior Case ReportsAuthor(s): Yongxin Li, Ya Wang, Zhen Tan, Qian Chen, Wenhua HuangAbstractThe main focus of the present study was to explore the longitudinal changes in the brain executive control system and default mode network after hemispherotomy. Resting-state functional magnetic resonance imaging and diffusion tensor imaging were collected in two children with medically intractable epilepsy underwent hemispherotomy. Two patients with different curative effect showed different trajectories of brain connevtivity after surgery. The failed hemispherotomy might due to that the synchrony of epileptic neurons in both hemispheres is preserved by residual neural pathways. Loss of interhemispheric correlations with increased intrahemispheric correlations can be considered as neural marker for evaluating the success of hemispherotomy.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research