Can the combination of hyperthermia, seizures and ion channel dysfunction cause fatal post-ictal cerebral edema in patients with SCN1A mutations?
We report on our patient and discuss whether the combination of hyperthermia and ion channel dysfunction may not only trigger seizures but also a fatal pathophysiological cascade of cerebral edema and herniation leading to cardiorespiratory collapse. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Pilot data on responsive epilepsy neurostimulation, measures of sleep apnea and continuous glucose measurements
ConclusionHippocampal nighttime responsive neurostimulation therapies did not appear to worsen measures of normal or abnormal sleep. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Emotional stimuli-provoked seizures potentially misdiagnosed as psychogenic non-epileptic attacks: A case of temporal lobe epilepsy with amygdala enlargement
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Hidetaka Tamune, Go Taniguchi, Susumu Morita, Yousuke Kumakura, Shinsuke Kondo, Kiyoto KasaiAbstractThe association between emotional stimuli and temporal lobe epilepsy (TLE) is largely unknown. Here, we report the case of a depressed, 50-year-old female complaining of episodes of a “spaced out” experience precipitated by emotional stimuli. Psychogenic non-epileptic attacks were suspected. However, video-EEG coupled with emotional stimuli-provoked procedures and MRI findings of amygdala enlargement, led to the diagnosis of left TLE. Accu...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Repetitive transcranial magnetic stimulation directed to a seizure focus localized by high-density EEG: A case report
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Robert Fisher, Jing Zhou, Adam Fogarty, Aditya Joshi, Matthew Markert, Gayle K. Deutsch, Mariel VelezAbstractWe demonstrate feasibility of using high-density EEG to map a neocortical seizure focus in conjunction with delivery of magnetic therapy. Our patient had refractory seizures affecting the left leg. A five-day course of placebo stimulation followed a month later by active rTMS was directed to the mapped seizure dipole. Active rTMS resulted in reduced EEG spiking, and shortening of seizure duration compared to placebo. Seizure frequenc...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Seizure freedom following surgery for multi-focal epilepsy due to cerebral malaria
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Peraya Piromruen, Chusak Limotai (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Postictal neurogenic pulmonary edema: Case report and brief literature review
We present a case of a 34-year-old woman with a history of Focal epilepsy since adolescence, who presented self-limited pulmonary edema following a focal to bilateral tonic–clonic seizure with subsequent resolution of the symptoms. We also made a brief review of neurogenic pulmonary edema, its proposed pathophysiology, treatment and its relation with sudden unexpected death in epilepsy (SUDEP). (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Visual hallucinations: A novel complication after hemispherectomy
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Jonas Vanags, Monisha Sachdev, Gerald Grant, Mohamad A. MikatiAbstractTwo patients at our center experienced florid visual hallucinations following hemispherectomy. The first patient had drug-resistant left hemispheric focal seizures at 20 months of age from a previous stroke. Following functional hemispherectomy at age 3, he experienced frightening hallucinations 1 month post-operatively lasting 3.5 months. Our second patient underwent subtotal hemispherectomy at age 6 for drug-resistant focal seizures from right hemispheric ...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Lacosamide-induced excessive laughing in a patient with Lennox–Gastaut syndrome
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Hussein Algahtani, Bader Shirah, Raghad AlgahtaniAbstractLacosamide is one of the third-generation antiseizure drugs that block voltage-gated sodium channels by enhancing slow inactivation. The most common adverse effects of lacosamide include dizziness, headache, nausea, vomiting, diplopia, fatigue, and sedation. Less common side effects include memory impairment, weight gain, rash, and atrioventricular block. In this article, we describe a patient with Lennox–Gastaut syndrome who developed excessive laughing as a rare side effect of lac...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Neurosurgical treatment of nonconvulsive status epilepticus due to focal cortical dysplasia
We present a rare case of focal cortical dysplasia (FCD) and nonconvulsive status epilepticus (NCSE) treated successfully with early surgical intervention. Our case is a 9-year-old boy whose seizures, characterized by short episodes of loss of consciousness, appeared at the age of 7, and he showed progressive cognitive decline in the following years. NCSE was diagnosed, and his MRI revealed FCD in the left frontal region which was the same side as his EEG abnormality. Following lesionectomy, his NCSE disappeared and cognitive functions improved. Histopathologic analysis of the resected tissue revealed type-IIB FCD. This ca...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Drug-resistant epilepsy development following stem cell transplant and cyclosporine neurotoxicity induced seizures: Case report in an adult and analysis of reported cases in the literature
ConclusionsThe use of cyclosporine for GvHD prophylaxis and treatment following transplantation may cause seizures and be associated with DRE. Although discontinuation and dose decrease of CSA often reverse adverse neurological events, initial CSA-induced seizures may be associated with MTS that and subsequent greater risk of DRE development. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Seizure frequency can be reduced by changing intracranial pressure: A case report in drug-resistant epilepsy
We report the case of a 23-year-old man who had undergone shunt surgery in childhood and later presented with focal impaired awareness seizures and behavior arrest. Seizures were uncontrolled despite 3 years of pharmacotherapy, but suddenly stopped after shunt removal. Our case supports the hypothesis that drug-resistant epilepsy can be influenced by changes in ICP. In particular, this case indicates that elevations in ICP may help reduce some seizures. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Recurrent seizures from chronic kratom use, an atypical herbal opioid
We report a 19-year-old male with recurrent seizures that developed during daily Kratom abuse as a self-treatment for anxiety. Following recurrent focal impaired awareness seizures in addition to generalized tonic–clonic seizures, he was begun on anti-seizure drugs. Seizures subsided after completing rehabilitation. Brain MRI at 29 months revealed bilaterally symmetric T1-hyperintensity in globus pallidus, subthalamic nuclei, and cerebral peduncles. Our case suggests Kratom abuse may be associated with structural brain lesions on MRI and symptomatic focal epilepsy. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Nilika S. Singhal, Adam L. Numis, Morgan B. Lee, Edward F. Chang, Joseph E. Sullivan, Kurtis I. Auguste, Vikram R. RaoAbstractResponsive neurostimulation for epilepsy involves an implanted device that delivers direct electrical brain stimulation in response to detection of incipient seizures. Responsive neurostimulation is a safe and effective treatment for adults with drug-resistant epilepsy, but although novel treatments are critically needed for younger patients, responsive neurostimulation is currently not approved for children with dru...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection
We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity. (So...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Language recovery after epilepsy surgery of the Broca's area
We report transient expressive aphasia followed by recovery of speech. This case provides new insights into adult neuroplasticity of the language network. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
