Therapeutic Augmentation of Ketogenic Diet with a Sodium-Glucose Cotransporter 2 Inhibitor in a Super-Refractory Status Epilepticus Patient
ConclusionSGLT2 inhibitors may have a therapeutic value in SRSE patients who cannot achieve ketosis with KD alone. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 10, 2018 Category: Neurology Source Type: research
Compound heterozygosity with PRRT2: Pushing the phenotypic envelope in genetic epilepsies
We describe a patient with compound heterozygous variants, infantile epilepsy with status epilepticus, paroxysmal dyskinesia and episodic ataxia.Testing revealed a pathogenic PRRT2 duplication (c.649dupC), and a likely pathogenic missense variant (c.916G>A).His presentation meets the severe phenotypic category with a combination of at least 3 neurological symptoms: seizures and status epilepticus, prolonged episodic ataxia, and paroxysmal dyskinesia. This further expands the clinical findings related to PRRT2, and suggests that compound heterozygous variants could confer a severe phenotype. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic–clonic seizure
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Andy Cheuk-Him Ng, Miljan Tripic, Seyed M. MirsattariAbstractHerein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic–clonic seizure and predominantly psychiatric symptoms, persisting long after EEG abnormalities had resolved. We discuss common presentations of anti-NMDA receptor encephalitis and advocate for the inclusion of this disease entity in the differential diagnosis of patients presenting with one generalized tonic–clonic seizure and prominent psychiatric symptoms. (Source...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Seizure remission and improvement of neurological function in sialidosis with perampanel therapy
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Su-Ching Hu, Kun-Long Hung, Hui-Ju Chen, Wang-Tso LeeAbstractA 15-year-old boy experienced myoclonic seizures for 3 years. He initially had occasional myoclonus, gradually progressive ataxia, tremors, and psychomotor and speech regression developed. Eventually, he exhibited nearly continuous myoclonus. He received treatment of sodium valproate, levetiracetam, clobazam, and phenobarbital, without efficacy. A ketogenic diet also proved ineffective. Adjunctive therapy with 4 mg/day of perampanel was started and was gradually titrated...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack to compare cognitive side effects of lacosamide and carbamazepine
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Claudio Liguori, Francesca Izzi, Natalia Manfredi, Nicola Biagio Mercuri, Fabio PlacidiAbstractCarbamazepine (CBZ) is a first generation anti-seizure drug, considered as first choice therapy in focal epilepsy but associated with cognitive side effects. Lacosamide (LCM) is a third-generation anti-seizure drug approved for treating focal epilepsy. This case series documented the comparable efficacy of LCM and CBZ as first add on treatments in patients affected by uncontrolled focal seizures. LCM showed an increase in EpiTrack scores, which me...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Seizures in HIV: The case for special consideration
ConclusionFor HIV + patients presenting with seizures/epilepsy the ASD prescription and the provision of supplementary support services needs to be carefully considered. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Autoimmune encephalitis associated with two antibodies
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Nikolai Gil D. Reyes, Mario B. Prado, Christian Wilson R. Turalde, Marc Laurence L. Fernandez (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Unusual seizure evolution: Focal-general-focal-general
We present another unusual type characterized by focal onset with secondary generalization, that is followed immediately by continued focal activity that generalizes again without an intervening break. Better understanding of these seizure types may allow improved targeted therapies and help shed light on the mechanistic underpinnings of epilepsy. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Patrick Kwan, Scott Mintzer, Antonio Laurenza, Anna Patten, Karen CartwrightAbstractPerampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is approved for adjunctive treatment of focal seizures, with or without secondarily generalized seizures, and for primary generalized tonic–clonic seizures in patients with epilepsy aged ≥ 12 years. Perampanel was recently approved for monotherapy use for focal seizures in the U.S.A. Anti-seizure drug monotherapy may be pref...
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Development and use of the art therapy seizure assessment sculpture on an inpatient epilepsy monitoring unit
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Sarah E. Brown, Tamara Shella, Elia Pestana-Knight (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
An interaction between warfarin and cannabidiol, a case report
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Leslie Grayson, Brannon Vines, Kate Nichol, Jerzy P. Szaflarski, for the UAB CBD Program (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Anterior corpus callosotomy in patients with drug-resistant epilepsy: Invasive EEG findings and seizure outcomes
We examined ictal scalp and intracranial electroencephalogram (iEEG) recordings in 16 patients being evaluated for anterior CC alone or CC in combination with focal resection, to determine the role of the iEEG in predicting postoperative seizure outcomes. In our cohort, CC improved generalized atonic seizures and focal seizures with impaired awareness but did not alter outcomes for generalized tonic–clonic or tonic seizures. Invasive EEG prior to CC did not refine the prediction of postsurgical seizure outcomes in patients with inconclusive scalp EEG. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Recurrent catamenial status epilepticus: Is it rare or an under recognized phenomenon in women with epilepsy?
Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 9Author(s): Albi J. Chalissery, Emer Murphy, Gerard Mullins, Peter Widdess-Walsh, Ronan Kilbride, Norman Delanty (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Sub-lobar dysplasia — A comprehensive evaluation with neuroimaging, magnetoencephalography and histopathology
We report a right temporal sublobar dysplasia, with detailed evaluation including neuroimaging, magnetoencephalography and histopathology to further characterize the pathology. Additional pathological features included a deep collateral sulcus in the basal right temporal lobe, thinned out right corticospinal tract, and bilateral asymmetric basal ganglia changes. Magnetoencephalograpy localized the seizure focus to the posterior margin of the dysplasia. Histopathological evaluation helped exclude other types of dysplasia. Similar to a previous study, the child had Engel 1a outcome. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
Conjoint glutamic acid decarboxylase 65 and P/Q voltage gated calcium channel antibodies in autoimmune epilepsy: A case report
This report highlights a possible role of P/Q VGCC antibodies in the pathogenesis of autoimmune epilepsy. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - July 5, 2018 Category: Neurology Source Type: research
