Combined targeted treatment in early onset epilepsy associated with tuberous sclerosis
We present a case report of a child with tuberous sclerosis who presented infantile spasms at the age of 6 months, immediately treated with vigabatrin. Due to presence of a subependymal giant cell astrocytoma he also received everolimus since 18 months of age. We might wonder if an earlier treatment could have produced a better outcome, in fact despite a targeted combined treatment he continues to suffer from sporadic focal motor seizures, and at the age of 40 months he presents severe developmental delay with autism-like behavior. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - January 13, 2016 Category: Neurology Source Type: research
Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of language processing including reading of exception and regular words, pseudohomophones, and dual meaning words confirmed the clinical hypothesis of right language dominance, with only small amounts of activation near the planned surgical resection and, thus, minimal eloquent cortex to avoid during surgery. Postoperatively, the patient ...
Source: Epilepsy and Behavior Case Reports - December 16, 2015 Category: Neurology Source Type: research
Praxis-induced seizures in a patient with juvenile myoclonic epilepsy: MEG-EEG coregistration study
Conclusions The present study demonstrates that the origin of epileptiform activity in JME can be localized in brain areas associated with the premotor frontal cortex. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - December 6, 2015 Category: Neurology Source Type: research
Pre-surgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Pre-surgical fMRI localization of language processing including reading of exception and regular words, pseudohomophones, and dual meaning words confirmed the clinical hypothesis of right language dominance, with only small amounts of activation near the planned surgical resection and thus minimal eloquent cortex to avoid during surgery. Post-operatively, the patient ...
Source: Epilepsy and Behavior Case Reports - December 3, 2015 Category: Neurology Source Type: research
Anti-NMDA-receptor antibody encephalitis in infants
Conclusion Infants with anti-NMDA-receptor antibody encephalitis can present with frank seizures or seizure mimics. Regardless, prompt recognition and aggressive treatment of anti-NMDA-receptor antibody encephalitis, while challenging, can quickly arrest deterioration and hasten recovery, thereby, limiting neurological morbidity. (Source: Epilepsy and Behavior Case Reports)
Source: Epilepsy and Behavior Case Reports - November 5, 2015 Category: Neurology Source Type: research
