Perampanel in lissencephaly-associated epilepsy

Publication date: Available online 11 January 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Satoru Ikemoto, Shin-ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Reiko KoichiharaAbstractWe retrospectively investigated whether perampanel (PER) could serve as an alternative for treating drug-resistant seizures in lissencephaly. We investigated the following data: age at onset of epilepsy, age at start of PER, etiology, brain MRI findings, seizure type, seizure frequency, adverse effects, and concomitant anti-epileptic drugs. There were 5 patients with lissencephaly, including 2 with Miller-Dieker syndrome. Four out of five patients exhibited ≥ 50% seizure reduction. Myoclonic seizures disappeared in 1 patient. PER was an effective adjunctive anti-seizure drug in our series of patients with lissencephaly.

Source: Epilepsy and Behavior Case Reports - January 12, 2019 Category: Neurology Source Type: research