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Extrathoracic investigation in adult patients with isolated pulmonary langerhans cell histiocytosis
Conclusions: Obtaining a thorough history and performing comprehensive physical examination are essential for staging patients diagnosed with PLCH. In the absence of symptoms or signs suggestive of extrapulmonary LCH involvement, the systematic performing of recommended bone imaging does not appear informative. Although the observed blood laboratory abnormalities were not specifically related to LCH, performing these tests in the diagnostic workup for PLCH is useful because some of these alterations may impact patient management.Trial registrationClinicalTrials.gov: No. NCT01225601; URL: www.clinicaltrials.gov (Source: Epi...
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Abdellatif TaziConstance de Margerie-MellonLaetitia VercellinoJean NaccacheStéphanie FryStéphane DominiqueStéphane JouneauGwenaël LorillonEmmanuelle BugnetRaphael ChironBenoit WallaertDominique ValeyreSylvie Chevret Source Type: research

An observational study of adult admissions to a medical ICU due to adverse drug events
Conclusions: ADE was a major cause of admission in the studied ICU, and in 59 % of the cases, ADEs were preventable. The reported burden of ICU admissions due to ADE advocates for further investigations to explore how the rate of such admissions could be decreased. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Pierre-Alain JolivotClaire PichereauPatrick HindletGilles HejblumNaïke BigéEric MauryBertrand GuidetChristine Fernandez Source Type: research

Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis
Conclusions: The current meta-analysis demonstrates that TNF-α-308G/A polymorphism in the TNF-α gene is associated with susceptibility to RPL. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Hui-Hui LiXing-Hua XuJing TongKai-Yue ZhangCong ZhangZi-Jiang Chen Source Type: research

Targeting autophagy to sensitive glioma to temozolomide treatment
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies have found that TMZ treatment could induce autophagy, which contributes to therapy resistance in glioma. To enhance the benefit of TMZ in the treatment of glioblastomas, effective combination strategies are needed to sensitize glioblastoma cells to TMZ. In this regard, as autophagy could promote cell survival or autophagic cell death, modulating autophagy using a pharmacological inhibitor, such as chloroquine, or an i...
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Yuanliang YanZhijie XuShuang DaiLong QianLunquan SunZhicheng Gong Source Type: research

Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
Conclusions: These in vivo observations reveals an important protective role for Nur77 in LPS-induced sepsis through its regulation to TRAF6 signalling, and highlights the potential clinical application of Nur77 as a molecular target in prevention and/or treatment of sepsis. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Xiu-Ming LiShen ZhangXiao-Shun HePeng-Da GuoXing-Xing LuJing-Ru WangJian-Ming LiHua Wu Source Type: research

Assessment of central venous catheter colonization using surveillance culture of withdrawn connectors and insertion site skin
Conclusion: Surveillance of NC and skin cultures could help to identify patients at risk for C-RBSI. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: María Pérez-GrandaMaría GuembeRaquel CrucesJosé BarrioEmilio Bouza Source Type: research

An accelerated dose escalation with a grass pollen allergoid is safe and well-tolerated: a randomized open label phase II trial
Conclusions: The dose escalation of a grass pollen allergoid can be accelerated with safety and tolerability profiles comparable to the conventional dose escalation. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: A. ChakerB. Al-KadahU. LutherU. NeumannM. Wagenmann Source Type: research

Psychotropic drug use among 0–17 year olds during 2004–2014: a nationwide prescription database study
Background: Time-trend studies on psychotropic drugs among children and adolescents are scarce, and most of them are outdated. The purpose of this study was to study prevalences of psychotropic drug use during 2004–2014 among Norwegians aged (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Ingeborg HartzSvetlana SkurtveitAnne SteffenakØystein KarlstadMarte Handal Source Type: research

Multifocal musculoskeletal tuberculosis mimicking multiple bone metastases: a case report
Conclusion: The proper diagnosis of musculoskeletal tuberculosis is clinically challenging due to Mycobacterium tuberculosis variants involved and atypical presentations, especially when the lesions are multiple. Our findings indicate that multiple tuberculous spondylitis must be considered in the differential diagnosis of multiple musculoskeletal lesions. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Meiping YeJinwei HuangJie WangJianmin RenJianfei TuWeibo YouTaohui Zhu Source Type: research

Drug-resistant tuberculosis control in China: progress and challenges
This article discussed the development of multidrug-resistant tuberculosis (MDR-TB) prevention and control in line with the on-going Chinese health system reform with a focus on financing for TB/MDR-TB care. Image: Combating drug-resistant tuberculosis in China. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Qian LongYan QuHenry Lucas Source Type: research

Access to and affordability of healthcare for TB patients in China: issues and challenges
This article introduces the background, aim and objectives of the project entitled "China - the Gates Foundation Collaboration on TB Control in China" and summarizes the key findings of the nine papers included in this special issue which used data from the baseline survey of Phase II of the project. Image: TB care in China. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Shenglan TangLixia WangHong WangDaniel Chin Source Type: research

Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis
Background: The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM). Methods: We conducted a comprehensive search for controlled studies that evaluated the efficacy and safety of MRAs in patients with DM and HF. Medline, Embase and Cochrane databases were searched. Two reviewers independently identified citations, extracted data and evaluated quality. Risk estimations were abstracted and pooled where appropriate. Results: Four observational studies were included. MRAs use was associated with r...
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Meng-Die ChenSi-Si DongNing-Yu CaiMeng-Di FanSu-Ping GuJin-Jue ZhengHai-Min YinXin-He ZhouLiang-Xue WangChun-Ying LiChao Zheng Source Type: research

A potential anatomic subtype of short bowel syndrome: a matched case-control study
Background: Fundamental researches suggest that ileum presents greater adaptive potential than the jejunum. However, few studies estimate the association between ileum and adaptive potential in human. To discover the association, we conducted this matched case-control study. Methods: A 1:2 pair-matched, case-control study was conducted from January 1, 2001 to January 1, 2015 in Intestinal Rehabilition and Transplant Center. The case group was ileum predominated (IP) group and the control group was jejunum predominated (JP) group. Demographic data, medical history and progression of each patient were collected. Results: The...
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Wencheng KongJian WangRongchao YingYousheng LiHuicheng JinQi MaoDanhua YaoMingxiao Guo Source Type: research

Diagnostic value of end tidal capnography in patients with hyperglycemia in the emergency department
Conclusion: Nasal capnography exhibits favourable diagnostic performance in detecting patients with or without DKA among those who present to the emergency department with a glucometer reading > 550 mg/dL. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Ralphe Bou CheblBryan MaddenJustin BelskyElie HarmoucheLenar Yessayan Source Type: research

Bee venom acupuncture alleviates trimellitic anhydride-induced atopic dermatitis-like skin lesions in mice
Conclusions: These results indicate that BV injection at specific acupuncture points effectively alleviates AD-like skin lesions by inhibiting inflammatory and allergic responses in a TMA-induced contact hypersensitivity mouse model. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Bongjun SurBombi LeeMijung YeomJu-Hee HongSunoh KwonSeung-Tae KimHyang LeeHi-Joon ParkHyejung LeeDae-Hyun Hahm Source Type: research