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Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant
Conclusion: Our work is significant not only because it sheds new light on the pathophysiology of EDS for the affected family and the field at large, but also because it demonstrates the utility of unbiased large-scale clinical recruitment in deciphering the genetic etiology of rare mendelian diseases. With unbiased large-scale clinical recruitment we strive to sequence as many rare mendelian diseases as possible, and this work in EDS serves as a successful proof of concept to that effect. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Akshatha DesaiJohn ConnollyMichael MarchCuiping HouRosetta ChiavacciCecilia KimGholson LyonDexter HadleyHakon Hakonarson Source Type: research

Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8 + T cells without host preconditioning
Conclusions: Collectively, our results identify how and when to administer TLR agonists to augment T cell-based immunotherapy in the absence or presence of host preconditioning for treatment of advanced malignancies. Our findings have clinical implications for the design of next generation immune-based therapies for patients with cancer. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Michelle NelsonJacob BowersStefanie BaileyMarshall DivenCaroline FugleAndrew KaiserClaudia WrzesinskiBei LiuNicholas RestifoChrystal Paulos Source Type: research

Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival
Conclusions: This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. Based on these data, the presence of ITC should be classified as a high risk factor in stage I & II colon cancer patients who might benefit from adjuvant chemotherapy. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: B. WeixlerR. WarschkowU. GüllerA. ZettlU. von HolzenB. SchmiedM. Zuber Source Type: research

Chimeric antigen receptor-engineered T cells in CLL: the next chapter unfolds
The long-standing promise for the application of engineered T lymphocytes to target and eradicate malignancy has begun to be realized recently, with remarkable clinical success reported by a number of groups using Chimeric Antigen Receptor –engineered T cells to target CD19-positive hematologic malignancies. In the September 2 issue of Science Translational Medicine, Porter et al. present the clinical data and correlative analyses for 14 CLL patients treated at the University of Pennsylvania under the pilot clinical trial recently completed at that institution. The initial reports from this trial, published in 2011 docum...
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Michael Kalos Source Type: research

Multiplexed tissue biomarker imaging
No description available (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Edward StackPeriklis FoukasPeter Lee Source Type: research

Making microbiology of the built environment relevant to design
Architects are enthusiastic about “bioinformed design” as occupant well-being is a primary measure of architectural success. However, architects are also under mounting pressure to create more sustainable buildings. Scientists have a critical opportunity to make the emerging field of microbiology of the built environment more relevant and applicable to real-world design problems by addressing health and sustainability in tandem. Practice-based research, which complements evidence-based design, represents a promising approach to advancing knowledge of the indoor microbiome and translating it to architectural practice. (...
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: G. BrownJeff KlineGwynne MhuireachDale NorthcuttJason Stenson Source Type: research

Mitral regurgitation as a phenotypic manifestation of nonphotosensitive trichothiodystrophy due to a splice variant in MPLKIP
Conclusion: This study extends the allelic and phenotypic spectra of MPLKIP-related TTDN, to include a splice variant that causes cardiomyopathy as part of the TTDN phenotype. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Khadim ShahRaja AliMuhammad AnsarKwanghyuk LeeMuhammad ChishtiIzoduwa AbbeBiao LiUniversity of Washington Center for Mendelian GenomicsJoshua SmithDeborah NickersonJay ShendurePaul CouckeWouter SteyaertMichael BamshadRegie Santos-CortezSuzanne LealWasim A Source Type: research

Are simulated patients effective in facilitating development of clinical competence for healthcare students? A scoping review
Conclusion: This scoping review serves to provide guidance for future healthcare education development, by illustrating the effectiveness of SPs in improving students’ clinical competence as evidenced in the literature. In doing so, it highlights the potential of SPs in facilitating students’ acquisition of the necessary skills for clinical practice. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Brett WilliamsJane Song Source Type: research

Disruption of clathrin-dependent trafficking results in the failure of grass carp reovirus cellular entry
Conclusion: Our findings suggest that GCRV might enter CIK cells via clathrin-mediated endocytosis in a pH-dependent manner. Additionally, dynamin is critical for efficient viral entry. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Hao WangWeisha LiuFei YuLiqun Lu Source Type: research

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
Conclusions: Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Katherine WoodsAshley J. KnightsMatthew AnakaRalf SchittenhelmAnthony PurcellAndreas BehrenJonathan Cebon Source Type: research

BMC Surgery reviewer acknowledgement, 2015
Contributing reviewersThe editors of BMC Surgery would like to thank all our reviewers who have contributed their time to the journal in Volume 15 (2015). (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 5, 2016 Category: Epidemiology Authors: Guangde Tu Source Type: research

Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study
Conclusion: Our study showed that the use of aspirin in critically ill patients was not associated with lower mortality, but rather with an increased morbidity.Trial Registration NumberISRCTN07413772 and ISRCTN96294863. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 5, 2016 Category: Epidemiology Authors: Shmeylan Al HarbiHani TamimHasan Al-DorziMusharaf SadatYaseen Arabi Source Type: research

Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer
Conclusions: Presurgical trials offer a means to study the impact of diet and exercise interventions directly on tumor tissue, and other host factors that are feasible and safe, though modifications are needed to conduct trials within an abbreviated period of time and via distance medicine-based approaches. Pre-surgical trials are critical to elucidate the impact of lifestyle interventions on specific mechanisms that mediate carcinogenesis and which can be used subsequently as therapeutic targets.Trial registrationNCT01886677 (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 5, 2016 Category: Epidemiology Authors: Wendy Demark-WahnefriedJeffery NixGary HunterSoroush Rais-BahramiRenee DesmondBalu ChackoCasey MorrowMaria AzradAndrew FrugéYuko TsurutaTravis PtacekScott TullyRoanne SegalWilliam Grizzle Source Type: research

Chinese Neurosurgical Journal reviewer acknowledgement 2015
Contributing reviewersThe editors of Chinese Neurosurgical Journal would like to thank all of our reviewers who have contributed to the journal in volume 1 (2015). (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 5, 2016 Category: Epidemiology Authors: Jizong Zhao Source Type: research

Abdominal tuberculosis manifested as tuberculosis of the urachal sinus in an adolescent and the role of laparoscopy in the management: a rare case report
Conclusion: This report highlights a rare case of TB urachal abscess in an adolescent boy, the difficulties in the diagnosis of abdominal tuberculosis, the need to consider TB as a cause of urachal infection in endemic areas and the use of laparoscopy in both diagnosis and treatment. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 5, 2016 Category: Epidemiology Authors: Sze SiowHon ShaChee Wong Source Type: research