Epidemiologic Perspectives and Innovations This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Challenges in personalised management of chronic diseases—heart failure as prominent example to advance the care process
Chronic diseases are the leading causes of morbidity and mortality in Europe, accounting for more than 2/3 of all death causes and 75 % of the healthcare costs. Heart failure is one of the most prominent, prevalent and complex chronic conditions and is accompanied with multiple other chronic diseases. The current approach to care has important shortcomings with respect to diagnosis, treatment and care processes. A critical aspect of this situation is that interaction between stakeholders is limited and chronic diseases are usually addressed in isolation.Health care in Western countries requires an innovative approach to a...
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Hans-Peter Brunner-La RoccaLutz FleischhackerOlga GolubnitschajaFrank HeemskerkThomas HelmsThom HoedemakersSandra AlliansesTiny JaarsmaJudita KinkorovaJan RamaekersPeter RuffIvana SchnurEmilio VanoliJose VerduBettina Zippel-Schultz Source Type: research

The impact of home, work, and church environments on fat intake over time among rural residents: a longitudinal observational study
Conclusions: Understanding stability and variability of dietary fat intake from a social ecologic perspective will aid in identifying targets of change for intervention. Understanding which components of key behavior settings are dynamic and which are relatively stable will help to disentangle the complexity of multi-level determinants of dietary behavior. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Regine HaardörferIris AlcantaraAnn AddisonKaren GlanzMichelle Kegler Source Type: research

Intimate partner violence as seen in post-conflict eastern Uganda: prevalence, risk factors and mental health consequences
Conclusion: In post-conflict eastern Uganda, in both gender, war torture was a risk factor for IPV victimisation and IPV victimisation was associated with mental health problems. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Eugene KinyandaHelen A WeissMargaret MunghereraPatrick Onyango-MangenEmmanuel NgabiranoRehema KajunguJohnson KagugubeWilson MuhweziJulius MuronVikram Patel Source Type: research

pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens
Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and response to this class of therapy. Methods to identify which tumor-specific mutant peptides (neoantigens) can elicit anti-tumor T cell immunity are needed to improve predictions of checkpoint therapy response and to identify targets for vaccines and adoptive T cell therapies. Here, we present a flexible, streamlined computational workflow for identification of personalized Variant Antigens by Cancer Sequencing (pVAC-Seq)...
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Jasreet HundalBeatriz CarrenoAllegra PettiGerald LinetteObi GriffithElaine MardisMalachi Griffith Source Type: research

Muscle mass, strength and functional outcomes in critically ill patients after cardiothoracic surgery: does neuromuscular electrical stimulation help? The Catastim 2 randomized controlled trial
Conclusions: NMES had no effect on MLT, but was associated with a higher rate in regaining muscle strength during the ICU stay. Regression of intramuscular edema during the ICU stay interfered with measurement of changes in MLT. At hospital discharge patients had regained preoperative levels of muscle strength, but still showed residual functional disability and decreased MLT compared to pre-ICU levels in both groups.Trial registrationClinicaltrials.gov identifier NCT02391103. Registered on 7 March 2015. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Arabella FischerMatthias SpieglKlaus AltmannAndreas WinklerAnna SalamonMichael Themessl-HuberMohamed MouhieddineEva StrasserArno SchifererTatjana Paternostro-SlugaMichael Hiesmayr Source Type: research

International publication trends and collaboration performance of China in healthcare science and services research
Conclusions: Despite the extensive achievement of the Chinese HSS reforms and research, gaps and challenges remain to be addressed, including those related to health insurance and the effects of the evaluation of essential medicine systems, human resources training and allocation in the health sector, government hospitals reforms and health services systems remodeling. These findings could help scholars and decision-makers understand the current status and likely future trends of the Chinese HSS research, and help them select the most appropriate collaboration partners and policies. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Kai ChenQiang YaoJu SunZhi-fei HeLan YaoZhi-yong Liu Source Type: research

Shedding light on research participation effects in behaviour change trials: a qualitative study examining research participant experiences
Conclusion: These participants described no dramatic impacts attributable to taking part in this study. This study demonstrates the likely value of well conducted qualitative studies of subtle research participation effects, which may be particularly important to explore for alcohol. Separating unintended influences in trial participation from the effects of behaviour change interventions being evaluated therein is necessary for valid estimates of intervention effects. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Virginia MacNeillMarian FoleyAlan QuirkJim McCambridge Source Type: research

Complementary alternative medicine use among patients with dengue fever in the hospital setting: a cross-sectional study in Malaysia
Conclusion: CAM was commonly used by patients with dengue fever. The predictor of CAM use was a higher level of education. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: SiewMooi ChingVasudevan RamachandranLai GewSazlyna LimWan SulaimanYoke FooZainul ZakariaNurul SamsudinPaul Chih Ming LauSajesh VeettilFankee Hoo Source Type: research

Relationship between regulatory T cells subsets and lipid profile in dyslipidemic patients: a longitudinal study during atorvastatin treatment
Conclusion: CD4 + CD25 high FoxP3+ regulatory cells seem to be over-stimulated in the early pre-clinical phase of atherosclerosis and a relationship exists between their frequency and circulating lipids. A potential immuno-modulation by statin treatment is not achieved through a normalization in peripheral CD4 + cell subsets. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Luigina GuastiAndrea MarescaLaura SchembriEmanuela RasiniFrancesco DentaliAlessandro SquizzatoCatherine KlersyLaura Robustelli TestChristian MongiardiLeonardo CampiottiWalter AgenoAnna GrandiMarco CosentinoFranca Marino Source Type: research

‘I don’t think I’d be frightened if the statins went’: a phenomenological qualitative study exploring medicines use in palliative care patients, carers and healthcare professionals.
Conclusions: There is a need to develop deprescribing strategies for patients with life-limiting illness. Such strategies should seek to establish patient expectations, consider the timing of the discussion about ceasing treatment and encourage the involvement of other stakeholders in the decision-making progress. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Adam ToddHolly HolmesSallie PearsonCarmel HughesInga AndrewLisa BakerAndy Husband Source Type: research

Vorvida: study protocol of a randomized controlled trial testing the effectiveness of Internet-based self-help program for the reduction of alcohol consumption for adults
This study is expected to establish the extent to which a novel Internet intervention could contribute to reducing problem drinking among adults with mild to severe alcohol use disorders who may or may not seek or access a traditional treatments. Potentially, this program could be an effective and efficient tool to help reduce problem drinking on a population level because a great number of users can be reached simultaneously without adding burden to treating clinicians.Trial registrationGerman Clinical Trial Registration (DRKS): DRKS00006104. Registered 14 April 2014. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Jördis ZillBjörn MeyerJanine ToppAnne DaubmannMartin HärterJörg Dirmaier Source Type: research

Right ventricular systolic dysfunction and remodelling in Nigerians with peripartum cardiomyopathy: a longitudinal study
This study thus aimed to assess RVSD and remodelling in a cohort of PPCM patients in Kano, Nigeria. Methods: A longitudinal study carried out in 3 referral hospitals in Kano, Nigeria. Consecutive PPCM patients who had satisfied the inclusion criteria were recruited and followed up for 12 months. RVSD was defined as the presence of either tricuspid annular plane systolic excursion (TAPSE) (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Kamilu KarayeKrister LindmarkMichael Henein Source Type: research

Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior
Conclusion: Our result showed that mucoepidermoid carcinomas are immunohistochemistry positive to CD44 compare to normal. A trend of CD44 expression associated with different histological grading and aggressive behavior of this tumor. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Nada BinmadiAzza ElsissiNadia Elsissi Source Type: research

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer’s disease
Conclusions: The primary outcome of this trial was negative. The data suggest that bexarotene reduced brain amyloid and increased serum Aβ 1–42 in ApoE4 noncarriers. Elevated triglycerides could represent a cardiovascular risk, and bexarotene should not be administered outside a research setting. RXR agonists warrant further investigations as AD therapies.Trial registrationClinicalTrials.gov identifier NCT01782742. Registered 29 January 2013. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Jeffrey CummingsKate ZhongJefferson KinneyChelcie HeaneyJoanne Moll-TudlaAbhinay JoshiMichael PontecorvoMichael DevousAnne TangJames Bena Source Type: research

Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments
Conclusions: The results in the present study suggest that the optical measurement on membrane roughness can be regarded as a label-free method to monitor the changes in cell mechanical properties or binding properties of nanoparticles on cell surface. Because the cells were left untouched during the measurement, further tests about cell viability or drug efficacy can be done on the same specimen. Membrane roughness could thus provide a quick screening for new chemical or physical treatments on neuronal cells. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - January 29, 2016 Category: Epidemiology Authors: Chia-Wei LeeLan-Ling JangHuei-Jyuan PanYun-Ru ChenChih-Cheng ChenChau-Hwang Lee Source Type: research