Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer’s disease
Conclusions:
The primary outcome of this trial was negative. The data suggest that bexarotene reduced brain amyloid and increased serum Aβ
1–42
in ApoE4 noncarriers. Elevated triglycerides could represent a cardiovascular risk, and bexarotene should not be administered outside a research setting. RXR agonists warrant further investigations as AD therapies.Trial registrationClinicalTrials.gov identifier NCT01782742. Registered 29 January 2013.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Jeffrey CummingsKate ZhongJefferson KinneyChelcie HeaneyJoanne Moll-TudlaAbhinay JoshiMichael PontecorvoMichael DevousAnne TangJames Bena Source Type: research
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