Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

Conclusions:
These in vivo observations reveals an important protective role for Nur77 in LPS-induced sepsis through its regulation to TRAF6 signalling, and highlights the potential clinical application of Nur77 as a molecular target in prevention and/or treatment of sepsis.

Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Xiu-Ming LiShen ZhangXiao-Shun HePeng-Da GuoXing-Xing LuJing-Ru WangJian-Ming LiHua Wu Source Type: research