The diagnostic utility of AMACR in the differentiation between solid pseudopapillary tumour and neuroendocrinal tumour of the pancreas: an immunohistochemical study using AMACR, CD10 and chromogranin A
Conclusion: AMACR expression can be validated as a diagnostic marker for SPPT of pancreas when the differential diagnosis of PET is in question. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Use of CD56 and cyclin D1 in differentiating thyroid hyperplasia from papillary thyroid carcinoma: an immunohistochemical study
Conclusion: We conclude that CD56 is an excellent negative marker for papillary carcinoma, so it can be used to differentiate between benign hyperplasia and papillary carcinoma, which is not the case for cyclin D1. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
A diagnostic immunohistochemical panel for challenging cases of high-grade urothelial carcinoma versus high-grade prostatic adenocarcinoma
Conclusion: We concluded that the newly discovered marker GATA3 with AMACR are the best preliminary panel to be applied in the challenging cases of high-grade UC and PC. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Aurora-A in transitional cell carcinoma of urinary bladder: an immunohistochemical study with clinicopathological correlation
This study was conducted as a trial to outline the characteristics of patients who may benefit from the targeted therapy using aurora-A inhibitors.
Materials and methods: This retrospective study was conducted on a total of 60 cases of TCC tissue samples. Cases were retrieved from the archives of the Pathology Department, Ain Shams University, and from the Pathology Lab of Ain Shams University Specialized Hospitals. Immunohistochemistry using the rabbit polyclonal anti-aurora-A antibody was carried out to detect the expression of aurora-A protein (diffuse cytoplasmic staining with or without nuclear staining), which was i...
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Immunostaining of Bcl-2 and HER2/neu in urinary bladder carcinoma
Conclusion: Expression of Bcl-2 in the bladder carcinoma seems to be associated with a less aggressive phenotype and does not play an important role in tumour progression. These findings support the role of HER2/neu in the carcinogenesis of urinary bladder carcinoma regarding behavior and aggressiveness, and thus HER2/neu could be considered as a poor prognostic parameter in urinary bladder carcinoma. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Effectiveness of calretinin immunohistochemistry with digital morphometry in mapping of different segments of Hirschsprung disease
Conclusion: Morphometric analysis with calretinin immunohistochemical study is a better method for precisely characterizing the transitional zone and easily delimiting the proximal margin of the transitional zone, which is considered a critical issue in surgery. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Expression of epithelial–mesenchymal transition-related markers E-cadherin and vimentin in ovarian serous carcinomas: correlation with transforming growth factor-β1 expression and clinicopathological factors
Conclusion: EMT process (loss of E-cadherin and expression of vimentin) is associated with progression and invasion of OSCs. TGF-β1 may enhance the invasiveness of OSCs through induction of EMT. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Evaluation of YAP protein expression and its value in tumorigenesis in molecular subtypes of invasive ductal carcinoma: an immunohistochemical study
Background: Yes-associated protein (YAP) is a transcription factor with contradictory results in breast cancer research, as it can act either as an oncogene or as a tumor suppressor. We aimed to clarify the role of YAP in breast cancer by examining YAP protein expression in different molecular subtypes of invasive ductal carcinoma and evaluate its value in prognosis.
Materials and methods: Immunohistochemical study for the expression of YAP and Ki-67 in 142 cases with invasive ductal carcinoma was conducted. The study included 50 luminal A, 32 luminal B, 27 HER-2 overexpressed, and 33 triple-negative cases. Fluorescent in...
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
Expression of claudin-3 and claudin-4 in gastric adenocarcinomas and precursor lesions
Conclusion: Upregulation of claudin-3 and claudin-4 expression during gastric carcinogenesis suggests their potential utility as diagnostic and prognostic molecular markers. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
AMACR versus COX-2 expression in benign prostatic hyperplasia and prostatic adenocarcinoma: a comparative study
Conclusion: Early detection can be made by estimation of AMACR antibody, and treatment must be focused more on AMACR than on COX-2 inhibitors. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
Granzyme B and perforin in lichen planus
Conclusion: Increased granzyme B and perforin expression in LP lesions may suggest a possible role of granzyme B and perforin in the pathogenesis of LP and could be the target for future immunomodulator therapy. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
Detection of chromosomal instability in preneoplastic flat lesions and conditions of the urinary bladder using UroVysion fluorescence in-situ hybridization
Conclusion: Detection of chromosomal imbalance with UroVysion fluorescence in-situ hybridization is a useful method for the detection of genetically unstable preneoplastic flat lesions and conditions, and can help in resolving difficult cases, particularly in the differential diagnosis of reactive atypia and dysplasia. Moreover, evaluation of ongoing genetic instability might provide additional insight into urinary bladder cancer risk assessment beyond that of the location and histology of the premalignant lesion. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
Expression of CDX-2 and ALK in primary gastric carcinoma: correlation with Her-2/neu status and prognostic factors
Conclusion: Combined expressions of CDX-2 and ALK in gastric carcinoma allow the classification of patients into groups with different prognosis, clinical outcomes, and treatment options. CDX-2+/ALK− cases were significantly associated with favorable prognostic factors. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
Cyclin D1 level, ploidy status, and S-phase fraction in colorectal cancer patients
Background: Colorectal carcinoma (CRC) is a common neoplasm representing the third most common cancer worldwide. In Egypt, it constitutes 5% of the total estimated cancers. Cyclin D1 is overexpressed in CRC. The prognostic value of cyclin D1 together with ploidy status and S-phase fraction (SPF) is still conflicting.
Aim: The aim of this study was to assess the prognostic value of cyclin D1, ploidy status, and SPF in CRC patients and evaluate its impact by correlating with histopathological characters.
Materials and methods: A total of 50 specimens of CRC were collected from National Cancer Institute, Cairo University. T...
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
Expression of Ki-67 and Bcl-2 in abortion material
Conclusion: Proliferation rate was decreased in fetal villous cytotrophoblasts and maternal deciduas in abortions. Moreover, loss of Bcl-2 expression in syncytiotrophoblasts may cause abortion in a subset of cases. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2015 Category: Pathology Tags: Original Articles Source Type: research
