Prognostic value of claudin-4, nm23-H1, and MIB-1 in undifferentiated nasopharyngeal carcinoma
Conclusion: Claudin-4 may be a novel biomarker for the prediction of distant metastasis and unfavorable prognosis in NPC, especially when combined with nm23-H1 and Ki-67. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - December 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Immunohistochemical study of cancer stem cell markers ‘OCT4’ and ‘CD44’ in correlation with COX2 in urinary bladder carcinoma
Background: Bladder cancer (BC) is the most common urologic cancer. Egypt is one of the endemic regions of BC. This high incidence of BC in Egypt is mainly attributed to schistosomiasis. Inflammation may activate stem cells through prostaglandin E2 production mediated by cyclooxygenase-2 (COX2) expression. In recent times, evidence has been accumulating to show that stem cells are involved in inflammation-related carcinogenesis. The most important members of cancer stem cells’ (CSCs) regulatory core are transcription factors including octamer 4 (OCT4). The cell adhesion molecule CD44 has also been identified as a cell su...
Source: Egyptian Journal of Pathology - December 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Differentiating mammary carcinoma from ovarian and endometrial carcinoma using GATA3, MAM, and PAX8 expression: validations and limitations
Conclusion: Immunohistochemical expression of GATA3 and PAX8 can be used as diagnostic markers in differentiating breast carcinomas from endometrial and ovarian carcinomas. However, MAM is strongly unadvisable as a breast tissue marker when ovarian or endometrial carcinomas are in question. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Significance of intrarenal B and T lymphocytic infiltrates in lupus nephritis
Conclusion: The current study concludes that interstitial inflammatory infiltrates and chronicity index but not activity index could be used as prognostic factors in LN and also concludes that the presence of intrarenal B : T-cell infiltrates and its grading could be used as a prognostic factor in patients with LN. It shall provide a hope for the management and improvement of prognosis of LN patients, especially the resistant cases, with trials with anti-CD20 drugs. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Cyclin D1 expression in psoriasis before and after phototherapy: an immunohistochemical study
Conclusion: Cyclin D1 upregulation may play a role in the pathogenesis of psoriasis. Downregulation of cyclin D1 may be a mechanism by which phototherapy induces remission in psoriasis. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Correlation between tumor budding, microvascular density, and β-catenin expression in colorectal carcinoma
Background: Colorectal cancer is one of the leading causes of cancer death worldwide. Therefore, identification of the clinicopathological prognostic factors associated with tumor growth, invasion, and metastasis is critical to develop proper therapeutic interventions. Tumor budding is a high-grade undifferentiated component of a tumor at the leading invasive edge that appears as small clusters ( (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Study of neurofilaments protein immunohistochemistry in basal cell carcinoma and trichoepithelioma as a feature of advanced differentiation
Conclusion: The immunohistochemical demonstration of perifollicular nerve plexuses in both BCC and TE indicates that both tumors are terminally differentiated and their presence is not of great value in differentiating the tumors. The ability of infiltration of BCC may be due to causes other than the stage of differentiation. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Immunohistochemical expressions of SQSTM1/p62, Beclin-1, and SOX4 in infiltrating duct carcinoma of the breast
This study aimed to detect immunohistochemical expressions of SQSTM1/p62 and Beclin-1, comparing their expressions with each other and with SOX4 expression in infiltrating duct carcinoma of the breast to determine the relation between their expressions and prognosis of that type of cancer.
Patients and methods: Immunohistochemical expressions of SQSTM1/p62, Beclin-1, and SOX4 were evaluated in sections from 60 paraffin blocks of invasive ductal carcinoma (IDC) of the breast. The relationship between their level of expressions and prognosis of the patients was analyzed.
Results: The expression of SQSTM1/p62, in IDC was si...
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Differentiation of bone marrow-derived mesenchymal stem cells in diabetic patients into islet-like insulin-producing cells: a new era in the treatment of diabetes
Conclusion: Human MSCs from diabetic and nondiabetic donors can be differentiated in vitro to form insulin-producing cells that can restore normoglycemia in diabetic mice. This source of material for autologous transplantation offers new opportunities for the treatment of diabetes. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Significance of immunohistochemistry and DNA ploidy in differential diagnosis of flat urothelial lesions and conditions using CK20, p53, CD44, ErbB-2, and image cytometry
Conclusion: In conclusion, a panel of CK20, p53, CD44, and ErbB-2 helps to differentiate urothelial CIS from non-neoplastic urothelial atypias. Positive staining for at least two of the three antibodies (CK20, p53, and ErbB-2) is strongly associated with CIS. DNA aneuploidy helps in differentiating CIS from reactive atypia. However, the histologic findings should be a primary determinant in the diagnosis of flat urothelial lesions, with IHC and DNA ploidy playing a supportive confirmatory role. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
HSP27 immunohistochemical expression in colorectal carcinoma: does it have a prognostic role?
Conclusion: HSP27 is a useful prognostic marker in CRC and plays an antiapoptotic role that affects the response to chemotherapy as well as radiotherapy. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Immunohistochemical expression of TWIST and H-TERT in benign and malignant prostatic lesions
Conclusion: TWIST expression can be used to differentiate between BPH and PIN, but not between PIN and prostatic carcinoma, whereas H-TERT proved to be more useful in differentiating between BPH, PIN, and carcinoma, besides its prognostic value, as it correlates significantly with the Gleason score. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Dystrophin expression in an Egyptian family suffering from muscular dystrophy
Conclusion: Dystrophin immunohistochemical staining confirms the diagnosis of Duchenne muscle dystrophy/Becker muscle dystrophy dystrophinopathy by showing different patterns of dystrophin protein expression. Although Duchenne muscle dystrophy/Becker muscle dystrophy are both X linked, yet, in our study, the female sibling showed severe disease expression possibly because of skewed X inactivation. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Expression of α-methyl coenzyme A racemase and p16 in colorectal adenoma and adenocarcinoma
Conclusion: AMACR as well as p16 were found to have a significant relation to the pathogenesis and some prognostic factors of CRC. Additional confirmatory studies are needed to establish the significance of AMACR and p16 as a prognostic marker for CRC, with a possible link between fatty diet, AMACR expression, and colon cancer development. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
Fatty acid synthase and hepsin expression in benign prostatic hyperplasia and prostatic carcinoma
This study was carried out on 82 cases, including 48 cases diagnosed as BPH and 34 cases diagnosed as PCa, received as paraffin blocks and fresh specimens.
Results: The immunohistochemical expression of fatty acid synthase was positive in the cytoplasm of three (6.25%) of 48 BPH cases and 32 (94.1%) of 34 PCa cases, with significantly higher expression in the higher Gleason scores (P (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2016 Category: Pathology Tags: Original Articles Source Type: research
