CD133 and CD44 as cancer stem cell markers in bladder carcinoma: an immunohistochemical study
Conclusion
CD44 and CD133 could be considered as markers predicting poor prognosis in bladder carcinoma. Both markers were significantly related to higher tumor grade and the presence of muscle invasion. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Expression of fatty acid synthase and E-cadherin markers in cancer of the prostate
Conclusion
Increased FASN immunohistochemical expression and reduced E-cadherin expression are associated with increased aggressiveness of prostatic carcinoma and bad prognosis. Combined detection of the expression of both markers may provide an essential predictor for prognosis of prostatic carcinoma. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
P57Kip2 immunohistochemical staining and flow cytometry ploidy analysis of hydatidiform moles and hydropic abortions
Conclusion
Current study shows that P57-negative expression identifies CHM cases, whereas FCM may aid in distinguishing PHMs from HAs. Hence, ancillary techniques can improve the diagnosis of hydropic gestations in morphologically equivocal cases. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Fluorescence in-situ hybridization versus chromogenic in-situ hybridization in evaluating HER2 status in breast cancer by adopting tissue microarray technique
Conclusion
HER2 testing by IHC and in-situ hybridization can be applied on TMA with high degree of sensitivity, specificity, and concordance. The low cost technique of TMA can replace automated TMAs in developing countries like Egypt, especially when using triplet cores. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Evaluation of cellular transformation and tumor aggressiveness factor expression in urinary bladder lesions and transitional cell carcinoma special variants in relation to bilharziasis
Background
Identification of molecular factors as diagnostic and prognostic indicators, as well as targets, for better therapy is a high priority. Human epidermal receptors constitute a family of receptor tyrosine kinases, which appear to be implicated in cellular transformation and can be overexpressed in a variety of solid tumors. Moreover, there has been a progressive interest in the expression of CD44 as a marker of tumor aggressiveness and metastatic potential in some human cancers.
Hypothesis
A variety of urinary bladder lesions and urothelial neoplasms are associated with alterations in epithelial growth factor...
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Immunohistochemical expression of nucleostemin and P53 in glioma
Conclusion
In view of our results, we assume that NS might play a relatively important role in the progression of glioma. Further studies in larger cohorts are warranted to elucidate the pathways coregulated with NS in glioma, in particular, those expressing mutant p53. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Molecular subtypes of breast cancer, do they differ in different age groups among Egyptian female individuals? (retrospective study)
Conclusion
Molecular subtypes of breast cancer vary with age with more luminal subtypes seen in elderly patients and more triple-negative basal-like carcinomas encountered in younger patients. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Immunohistochemical expression of stem cell markers CD133 and Oct-4 in cases of endometrial hyperplasia and endometrial carcinoma
Conclusion
A positive correlation between the markers CD133 and Oct4 and the tumor stage was observed, indicating that CD133 and Oct4 may be used as significant prognostic markers. Further studies with larger sample sizes and follow-up data of longer intervals are recommended. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Expression of HER2 and topoisomerase II α in urinary bladder transitional and squamous cell carcinoma
Conclusion
According to our results, more than half of TCC cases were either positive for both HER2 and TOP2α or positive for one of them. Therefore, target therapy against these proteins could have a significant role in the management of Egyptian patients. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Role of ALDH1a and CD44 in transitional and squamous cell carcinomas of urinary bladder
Conclusion
ALDH1a expression was associated with unfavorable features such as advanced stage in TCC cases and high grade in SCC cases. ALDH1a+ cells constitute a subpopulation of CD44+ cells and might represent more primitive CSCs. Target therapy against ALDH1a could be effective, especially in advanced tumors. Target therapy against CD44 could be helpful for bladder SCC or TCC with squamous differentiation. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Transforming growth factor-β1, connective tissue growth factor, and inducible nitric oxide synthesase in hepatitis C-positive chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in Upper Egypt
Conclusion
The upregulation of these proteins suggests their role in development of LC and carcinoma. Therefore, TGF-β1, CTGF, and iNOS are possible potential therapeutic targets for LC and HCC. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Does Beclin-1 have a role in hepatocellular carcinoma in Egyptian patients?
Conclusion
Beclin-1 is a good prognostic marker in view of the association between low Beclin-1 expression and high lymphovascular invasion and advanced pathological stage. Moreover, there is a reciprocal talk between Beclin-1 and Bcl-2, as under stressful conditions (HCC or cirrhosis) Beclin-1 dissociated from the Beclin-1–Bcl-2 complex, modulating the tumor suppressor action of Beclin-1. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Diagnostic value of the combined use of SATB2 and CDX2 in mucinous carcinoma of colorectal origin
Conclusion
SATB2 is a more sensitive yet less specific marker for diagnosis of mucinous carcinoma of colorectal origin as compared with CDX2. SATB2 in combination with CDX2 increases the accuracy of distinguishing mucinous carcinomas of colorectal origin from mucinous carcinomas of other origins; therefore, SATB2 is considered a useful marker in this respect. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
FOXP3-positive regulatory T cells are correlated with improved survival in diffuse large B-cell non-Hodgkin lymphoma
Conclusion
Our results point to the favorable prognostic impact of FOXP3-positive Tregs in both germinal and nongerminal center types of DLBCL and the possible additional information that can be added for better stratification of patients and therapy individualization by estimating FOXP3 expression, irrespective of the molecular subtype of DLBCL. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Fragile histidine triad protein expression in colorectal adenoma and carcinoma: an immunohistochemical and image analysis study
Conclusion
The reduction of FHIT expression occurs with rising grade of dysplasia and malignant colorectal tumors and its low expression is associated with poor prognostic factors such as lymph node metastasis, presence of distant metastasis, vascular and perineural invasion, high grade, and advanced stages. Furthermore, the CIA technique provides a more accurate assessment of the staining patterns and helps to evaluate intensity better than when depending on subjective light microscopy alone. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
