Immunohistochemical expression of Bmi-1, S100A4, and claudin-1 in breast cancer
This study aimed to assess the expression of Bmi-1, S100A4, and claudin-1 in immunostained specimens of breast cancer and correlate their immunohistochemical expression with the clinicopathological parameters to identify their impact on tumor behavior and carcinogenesis.
Materials and methods
Bmi-1, S100A4, and claudin-1 immunohistochemical expressions were evaluated and analyzed in 50 paraffin-embedded specimens of breast cancer.
Results
Bmi-1, S100A4, and claudin-1 expression was found in 58, 44, and 34%, respectively, of the studied cases. There was a significant positive association between Bmi-1 expression and t...
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Predictive role of leptin and cyclin D1 in papillary thyroid carcinoma: an immunohistochemical study
Conclusion
We conclude that the expressions of leptin and cyclin D1 in PTC are associated with neoplasm aggressiveness, including advanced stage and presence of lymph node metastasis. Absence of both leptin and cyclin D1 expressions in normal noncancerous follicular cells and multinodular goiter cases indicates their role in early carcinogenesis of PTC. Novel opportunities could emerge from the discovery of leptin crosstalk with other oncogenic pathways, inflammatory and angiogenic cytokines, and links to obesity-related cancers. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Correlation between epidermal growth factor receptor and MIB-1 index in different grades of astrocytomas
Conclusion
A significant correlation was found between EGFR overexpression and MIB-1 LI in grade II, grade III, and gliobastoma multiform. These may suggest that tumor proliferation, at least in the higher grades of astrocytomas, depends up to some extent on epidermal growth factor and EGFR-related signaling pathways. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
CD24 expression in retinoblastoma: a potential prognostic role
Conclusion
CD24 is overexpressed in retinoblastoma, and immunohistochemically determined CD24 expression is a potential marker of prognosis in this disease. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
The role of AMARC and cytokeratin 5/6 in differentiation between carcinoma in situ and reactive urothelial atypia in comparison with previously studied markers
Conclusion
The two markers used in the current study, AMARC and CK5/6, can be used to differentiate between urothelial CIS and reactive atypia. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Immunohistochemical characterization of the molecular subtypes of invasive breast carcinoma in a series of Egyptian female patients with clinicopathologic correlation
Conclusion
The luminal B HER2-negative subtype is the most common molecular subtype among female breast carcinomas at our center. The incidence of basal-like and penta-negative tumors is lower than that in other countries. The luminal subtypes in contrast to HER2-positive molecular subtypes are more likely to present as low-grade and stage tumors. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Estrogen receptors and progesterone receptors expression in endometrial carcinoma in diabetic versus nondiabetic patients
Conclusion
There was no difference in the expression patterns of ER and PR in the glands and stroma between diabetic and nondiabetic EC patients. The parallel expression of both receptors was inversely proportional to the tumor grade. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Differential vascular endothelial growth factor expression in neoplastic and non-neoplastic components of classic Hodgkin’s lymphoma
Background
Although the available treatment modalities for Hodgkin’s lymphoma (HL) are usually successful, a large number of HL patients still relapse after initial therapy. It is, therefore, essential to study the biology of HL, in a trial to improve patients’ outcomes and therapeutic modalities. Angiogenesis is a mandatory step for tumor growth and progression. Vascular endothelial growth factor (VEGF) is one of the principle angiogenic factors to answer the question, ‘which cells are contributing more in angiogenesis of HL and should be attacked first in tumor therapy?’ The present study aimed to evaluate VEGF...
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
The diagnostic utility of carbonic anhydrase IX, α-methylacyl-coenzyme A racemase, and BSND in classifying renal cell carcinoma: an immunohistochemical study
The objective of this study was to evaluate the diagnostic ability of carbonic anhydrase IX (CA IX), α-methylacyl-coenzyme A racemase (AMACR), and Bartter-syndrome, type-4a Sensorineural-deafness & renal dysfunction (BSND) expression in differentiating the three main types of RCC – cc-RCC, pp-RCC, and cp-RCC.
Patients and methods
Immunohistochemical expressions of CA IX, AMACR, and BSND were assessed in 50 paraffin blocks from patients with RCC.
Results
CA IX was significantly positive in cases of cc-RCC (P (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
The role of immunohistochemical expression of OCT-4 and SOX2 as predictors of recurrence and progression in superficial urinary bladder carcinoma
Conclusion
The present study reveals that tumor size is an important clinical risk factor for tumor recurrence and progression.
Positive OCT-4 expression may be a predictive marker in NMIBC progression. More prospective studies on different stages of UBC are needed to clarify the potential role of OCT-4 in the biology and behavior of UBC.
However, SOX2 has limited role in early-stage bladder cancer. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Autophagy-related molecules, light chain 3B, p62, and beclin 1, as prognostic markers in triple-negative breast cancer
Background and aim
Triple-negative breast cancer (TNBC) is associated with aggressive behavior and poor clinical outcome. Therefore, identification of biomarkers predicting prognosis may help to improve the clinical outcome of TNBC. Autophagy is a process of lysosomal degradation and recycling of intracellular components. It plays an important role in normal cells as well as in malignant cells.
The aim of this study was to investigate the pattern of expression of autophagy-related molecules, light chain 3B (LC3B), p62, and beclin 1, their relationship with clinicopathological features, and their prognostic value in TNBC...
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Stromal expression of CD10 in invasive breast carcinoma and its correlation with clinicopathological parameters
Conclusion
From the present study, it can be concluded that CD10 stromal expression may be implicated in breast cancer tumorigenesis. CD10 is associated with poor prognostic indicators in breast cancer, and thus may contribute to tumor aggressiveness and progression. CD10 expression is a potential poor prognostic factor in breast cancer and might help identify a group of patients with higher propensity to tumor recurrence, which might aid in patient management. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
The utility of ThinPrep cytology and immunohistochemical staining of p16INK4a, Ki-67, and p63 in the assessment of cervical intraepithelial neoplasia (dysplasia)
Background: Cervical intraepithelial neoplasia (CIN) is a precancerous lesion with the capability of progressing to squamous-cell carcinoma (SCC). Despite the clearly defined criteria, histopathological diagnoses in hematoxylin and eosin-stained sections are subject to high rates of interpathologist discordance. The aim of this study was to compare and evaluate the results of both ThinPrep cytology and the immunohistochemical-staining pattern of p16, Ki-67, and p63, in diagnosing and grading cervical dysplasia. After such a comparison, the researchers hoped that the diagnostic accuracy in equivocal cases would improve.
Pa...
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
CD133 and CD44 as cancer stem cell markers in bladder carcinoma: an immunohistochemical study
Conclusion: CD44 and CD133 could be considered as markers predicting poor prognosis in bladder carcinoma. Both markers were significantly related to higher tumor grade and the presence of muscle invasion. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
Expression of fatty acid synthase and E-cadherin markers in cancer of the prostate
Conclusion: Increased FASN immunohistochemical expression and reduced E-cadherin expression are associated with increased aggressiveness of prostatic carcinoma and bad prognosis. Combined detection of the expression of both markers may provide an essential predictor for prognosis of prostatic carcinoma. (Source: Egyptian Journal of Pathology)
Source: Egyptian Journal of Pathology - July 1, 2017 Category: Pathology Tags: Original Articles Source Type: research
