Aurora-A in transitional cell carcinoma of urinary bladder: an immunohistochemical study with clinicopathological correlation

This study was conducted as a trial to outline the characteristics of patients who may benefit from the targeted therapy using aurora-A inhibitors. Materials and methods: This retrospective study was conducted on a total of 60 cases of TCC tissue samples. Cases were retrieved from the archives of the Pathology Department, Ain Shams University, and from the Pathology Lab of Ain Shams University Specialized Hospitals. Immunohistochemistry using the rabbit polyclonal anti-aurora-A antibody was carried out to detect the expression of aurora-A protein (diffuse cytoplasmic staining with or without nuclear staining), which was in turn correlated with clinicopathological factors. Results: Immunohistochemical staining of aurora-A expression was cytoplasmic with or without nuclear expression in malignant urothelial cells. Higher expression of aurora-A protein expression correlated significantly with histological type (P=0.04), histologic grade (P=0.04), and depth of invasion (pathological T-stage) (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research