The story of poorly differentiated thyroid carcinoma: From Langhans ’ description to the Turin proposal via Juan Rosai
Rosai, reinterpreting Langhans ’ “proliferating goiter,” adopted the term “poorly differentiated carcinoma” for a specific thyroid tumor with insular features 30 years ago. This tumor type is only one of those approached by Dr. Rosai in the thyroid field (a PubMed search as of August 31, 2015 on “Rosai& thyroid ” disclosed 73 articles), but seems the most innovative and representative of his heavy contribution to thyroid tumor classification. The diagnostic problems associated with PDTC recognition date back a long time, with a still ongoing debate on the nature of PDTC, its morphological diagnostic feat ures...
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Marco Volante, Gianni Bussolati, Mauro Papotti Source Type: research
Rosai –Dorfman disease: Familiar yet enigmatic
The disorder known as “sinus histiocytosis with massive lymphadenopathy” was originally described by Destombes1 in 1965 as “adenitis with lipid excess.” However, it fell to Rosai and Dorfman2,3 in 1969 and 1972 to delineate this as a distinct entity and characterize its clinical and pathologic features. Since ext ranodal manifestations are common, and lymph nodes are not always involved, the eponymous designation of “Rosai–Dorfman disease (RDD)” is preferred in most of the world (and as Destombes–Rosai–Dorfman disease in France). (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Steven H. Kroft Source Type: research
The story of poorly differentiated thyroid carcinoma: From Langhans ’ description to the Turin proposal via Juan Rosai
Rosai, reinterpreting Langhans ’ “proliferating goiter,” adopted the term “poorly differentiated carcinoma” for a specific thyroid tumor with insular features 30 years ago. This tumor type is only one of those approached by Dr. Rosai in the thyroid field (a PubMed search as of August 31, 2015 on “Rosai & thyroid ” disclosed 73 articles), but seems the most innovative and representative of his heavy contribution to thyroid tumor classification. The diagnostic problems associated with PDTC recognition date back a long time, with a still ongoing debate on the nature of PDTC, its morphological diagnostic feat ur...
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Marco Volante, Gianni Bussolati, Mauro Papotti Source Type: research
Rosai –Dorfman disease: Familiar yet enigmatic
The disorder known as “sinus histiocytosis with massive lymphadenopathy” was originally described by Destombes1 in 1965 as “adenitis with lipid excess.” However, it fell to Rosai and Dorfman2,3 in 1969 and 1972 to delineate this as a distinct entity and characterize its clinical and pathologic features. Since ext ranodal manifestations are common, and lymph nodes are not always involved, the eponymous designation of “Rosai–Dorfman disease (RDD)” is preferred in most of the world (and as Destombes–Rosai–Dorfman disease in France). (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Steven H. Kroft Source Type: research
Rosai–Dorfman disease: Familiar yet enigmatic
The disorder known as “sinus histiocytosis with massive lymphadenopathy” was originally described by Destombes1 in 1965 as “adenitis with lipid excess.” However, it fell to Rosai and Dorfman2,3 in 1969 and 1972 to delineate this as a distinct entity and characterize its clinical and pathologic features. Since extranodal manifestations are common, and lymph nodes are not always involved, the eponymous designation of “Rosai–Dorfman disease (RDD)” is preferred in most of the world (and as Destombes–Rosai–Dorfman disease in France). (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Steven H. Kroft Source Type: research
The story of poorly differentiated thyroid carcinoma: From Langhans’ description to the Turin proposal via Juan Rosai
Rosai, reinterpreting Langhans’ “proliferating goiter,” adopted the term “poorly differentiated carcinoma” for a specific thyroid tumor with insular features 30 years ago. This tumor type is only one of those approached by Dr. Rosai in the thyroid field (a PubMed search as of August 31, 2015 on “Rosai & thyroid” disclosed 73 articles), but seems the most innovative and representative of his heavy contribution to thyroid tumor classification. The diagnostic problems associated with PDTC recognition date back a long time, with a still ongoing debate on the nature of PDTC, its morphological diagnostic features, ...
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Marco Volante, Gianni Bussolati, Mauro Papotti Source Type: research
The story of poorly differentiated thyroid carcinoma
Thirty years ago Rosai, reinterpreting Langhans’ “proliferating goiter”, adopted the term “Poorly differentiated carcinoma” for a specific thyroid tumor with insular features. This tumor type is only one of those approached by dr. Rosai in the thyroid field (a Pubmed search as of August 31 2015 on “Rosai & thyroid” disclosed 73 articles), but seems the most innovative and representative of his heavy contribution to thyroid tumor classification. The diagnostic problems associated to PDTC recognition date back a long time, with a still ongoing debate on the nature of PDTC, its morphological diagnostic features,...
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Marco Volante, Gianni Bussolati, Mauro Papotti Source Type: research
Rosai-dorfman disease: Familiar yet enigmatic
The disorder known as “Sinus histiocytosis with massive lymphadenopathy” was originally described by Destombes in 1965as “Adenitis with lipid excess.”1 However, it fell to Rosai and Dorfman in 1969 and 1972 to delineate this as a distinct entity and characterize its clinical and pathologic features.2,3 Since extranodal manifestations are common, and lymph nodes are not always involved, the eponymous designation of “Rosai-Dorfman disease (RDD)” is preferred in most of the world (and as Destombes-Rosai-Dorfman disease in France). (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 19, 2016 Category: Pathology Authors: Steven H. Kroft Source Type: research
Birth and evolution of the desmoplastic small round-cell tumor
This article reviews the original characterization of this neoplasm, and the eventual expansion of its clinical and pathological spectrum. Relevant data on its molecular features are summarized, in order to understand the search for therapeutic targets. The challenge ahead is to better know and cure this disease through the finding and validation of actionable therapeutic targets. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Enrique de Alava, David Marcilla Source Type: research
Diagnostic electron microscopy and the influence of Dr. Juan Rosai
Transmission electron microscopy (TEM) was introduced by Ruska and Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalog the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai and Rodriguez authored an important article, introducing the concept that TEM could be used for the differential diagnosis of histologically similar neoplasms. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Multicentric Castleman disease: Where are we now?
Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity that causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can also...
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Hao-Wei Wang, Stefania Pittaluga, Elaine S. Jaffe Source Type: research
Birth and evolution of the desmoplastic small round-cell tumor
This article reviews the original characterization of this neoplasm, and the eventual expansion of its clinical and pathological spectrum. Relevant data on its molecular features are summarized, in order to understand the search for therapeutic targets. The challenge ahead is to better know and cure this disease through the finding and validation of actionable therapeutic targets. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Enrique de Alava, David Marcilla Source Type: research
Diagnostic electron microscopy and the influence of Dr. Juan Rosai
Transmission electron microscopy (TEM) was introduced by Ruska and Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalog the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai and Rodriguez authored an important article, introducing the concept that TEM could be used for the differential diagnosis of histologically similar neoplasms. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Birth & evolution of the desmoplastic small round-cell tumor
The landmark description of desmoplastic small round cell tumor was reported in 1991. The article described a series of 19 patients with small round cell tumors with a remarkable consistency in their clinical presentation and immunophenotype which suggested they represented a new and distinctive clinicopathological entity (Gerald, 1991). Although the reader could think this article is the original presentation of the disease, William L. Gerald and Juan Rosai first presented their proposal as a single intriguing case in an evening specialty conference at the USCAP meeting in 1988. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Enrique de Alava, David Marcilla Source Type: research
Diagnostic electron microscopy & the influence of Dr. Juan rosai
Transmission electron microscopy (TEM ) was introduced by Ruska & Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalogue the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai & Rodriguez authored an important paper, introducing the concept that TEM could be used for the differential diagnosis of histologically-similar neoplasms. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
