Pulmonary and pleural pathology: Contributions of Dr. Louis “Pepper” Dehner
Dr. Louis Dehner is an internationally renowned surgical pathologist who has published multiple textbooks and has authored or co-authored nearly 400 original articles in the medical literature. While many think of him as a pediatric pathologist, he has contributed to the literature across virtually the entire breadth of surgical pathology, and the lung and pleura is no exception. This review will highlight Dr. Dehner ׳s contributions to the pulmonary and pleural pathology literature in the areas of infectious disease, medical lung disease and transplant pathology, and a number of neoplasms of the lung and pleura, with the...
Source: Seminars in Diagnostic Pathology - September 20, 2016 Category: Pathology Authors: Jon H. Ritter, D. Ashley Hill Source Type: research
Pulmonary and pleural pathology: Contributions of Dr. Louis “Pepper“ dehner
Dr. Louis Dehner is an internationally renowned surgical pathologist who has published multiple textbooks and has authored or co-authored nearly 400 original articles in the medical literature. While many think of him as a pediatric pathologist, he has contributed to the literature across virtually the entire breadth of surgical pathology, and the lung and pleura is no exception. This review will highlight Dr. Dehner's contributions to the pulmonary and pleural pathology literature in the areas of infectious disease, medical lung disease and transplant pathology, and a number of neoplasms of the lung and pleura, with the r...
Source: Seminars in Diagnostic Pathology - September 20, 2016 Category: Pathology Authors: Jon H. Ritter, D. Ashley Hill Source Type: research
Testicular germ cell tumors (TGCTs) in neonates and infants
What occurs to “pediatric” patients is influenced by biologic changes that occur during development and adolescence and the different susceptibility during this period to internal and external factors that can cause disease. Specialists of various medical disciplines involved in the treatment of “pediatric” patients usually include in their practice patients in the first 2 decades of life. In the field of TGCTs, two very different types of neoplasms occur in “pediatric” patients: The very young, and the adolescent. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - September 5, 2016 Category: Pathology Authors: Juan Carlos Manivel Source Type: research
Testicular germ cell tumors (TGCT) in neonates and infants
What occurs to “pediatric” patients is influenced by biologic changes that occur during development and adolescence and the different susceptibility during this period to internal and external factors that can cause disease. Specialists of various medical disciplines involved in the treatment of “pediatric” patients usually include in their practice patients in the first two decades of life. In the field of TGCT two very different types of neoplasms occur in “pediatric” patients: the very young, and the adolescent. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - September 5, 2016 Category: Pathology Authors: Juan Carlos Manivel Source Type: research
Pediatric soft tissue tumor pathology: A happy morpho-molecular union
Since its foundation by remarkably talented and insightful individuals, prominently including Pepper Dehner, pediatric soft tissue tumor pathology has developed at an immense rate. The morphologic classification of tumoral entities has extensively been corroborated, but has also evolved with refinement or realignment of these classifications, through accruing molecular data, with many derivative ancillary diagnostic assays now already well-established. Tumors of unclear histogenesis, classically morphologically undifferentiated, are prominent amongst pediatric sarcomas, however, the classes of undifferentiated round- or sp...
Source: Seminars in Diagnostic Pathology - September 4, 2016 Category: Pathology Authors: Maureen O ’Sullivan Source Type: research
Contributions of dr. louis “pepper” dehner to the art of cutaneous pathology, the first pediatric dermatopathologist
Dr. Louis “Pepper” Dehner has been one of the most influential surgical pathologists of the last century. Authoring more than 450 publications, he is the premier modern pediatric pathologist. Perhaps, an area that he is less recognized and in which we would like to describe his contributions, is his role as a creator of the art of pediatric dermatopathology. Dr. Dehner has had at least 50 major publications describing, discovering and orienting the discipline in the fields of fibrohistiocytic disorders of childhood, vascular tumors, and histiocytosis among many others. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - September 4, 2016 Category: Pathology Authors: Alejandro A. Gru, M.D. Horacio Maluf Source Type: research
Pediatric Soft Tissue Pathology: A Happy Morpho-Molecular Union
It is my honor to discuss pediatric soft tissue tumor pathology in the Festschrift dedicated to my mentor, Pepper Dehner. No other pediatric pathologist has authored more soft tissue-related publications. To summarise pediatric soft tissue tumor pathology into just 10 pages would do neither this phenomenally interesting subject, nor the multitudinous, seminal contributions of Pepper Dehner to the field, justice. Rather than providing an exhaustive historical report here of all pediatric soft tissue neoplasms from the histological perspective, especially as this has been extensively dealt with, most recently through a full ...
Source: Seminars in Diagnostic Pathology - September 4, 2016 Category: Pathology Authors: Maureen O ’Sullivan Source Type: research
Pathology of the Liver in Children: Where would I (we) be without “Pepper”?
Our distinguished leader, and my dear friend of 40+ years, has been an inspiration and source of knowledge in how to examine and interpret surgical pathology samples from every organ and tissue, but perhaps the liver has had the longest run for his attention. While we have not always seen “eyepiece to eyepiece” on a particular issue - the prognostic and therapeutic importance of histopathologic categorization of hepatoblastoma - I cannot imagine performing my duties and efforts at scholarship without Pepper′s many carefully detailed and illustrated lessons. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - September 2, 2016 Category: Pathology Authors: Milton J. Finegold Source Type: research
Histiocytic Proliferations
The study of Histiocytic lesions has been a passion of Pepper Dehner over the years. He has contributed several case series and reviews on various categories of these diseases for over 4 decades, with his earliest papers in the 1970s. He has written on all aspects of the disease including seminal papers on Langerhans cell histiocytosis (LCH) and their prognostic features, his experiences with regressing atypical histiocytosis, his encounters with malignant histiocytosis, and classic papers on juvenile xanthogranuloma. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - August 31, 2016 Category: Pathology Authors: Sarangarajan Ranganathan Source Type: research
Introduction
Almost 20 years ago, a singular book appeared that considered the history of surgical pathology in the United States. Edited by Juan Rosai and entitled “Guiding the Surgeon′s Hand” (American Registry of Pathology, Washington, DC, 1997), that text contained chapters which dealt with the contributions of laboratory physicians in the foremost teaching medical centers of the 20th century. Those included Washington University in St. Louis (WUSL); Johns Hopkins Hospital; the College of Physicians& Surgeons of Columbia University; Memorial Sloan-Kettering Cancer Center; the Harvard University system; the Mayo Clinic; and th...
Source: Seminars in Diagnostic Pathology - August 30, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
All things rhabdoid and smarc: An enigmatic exploration with dr. Louis P. Dehner
Over the past several decades, our understanding of malignant rhabdoid tumors (MRT) and the central nervous system equivalent Atypical Teratoid / Rhabdoid Tumor (ATRT) has undergone considerable refinement, particularly in terms of genetic characterization. MRT (both renal and extra-renal) and ATRT share phenotypic similarities and a common genetic signature, that being inactivating alterations of the SWI/SNF complex component SMARCB1 (or rarely SMARCA4). Unfortunately, a wide array of tumors bears significantly overlapping phenotypic characteristics to MRT/ATRT, posing a formidable diagnostic challenge. (Source: Seminars ...
Source: Seminars in Diagnostic Pathology - August 30, 2016 Category: Pathology Authors: Christine E. Fuller Source Type: research
Pediatric renal and genitourinary tract tumors and the contributions of Dr. Louis “Pepper” Dehner therewith
Dr. Louis “Pepper” Dehner is an internationally renowned surgical pathologist, especially in the subspecialty of pediatric pathology. Although his clinical and academic expertise are broad, with over 400 published papers, some of his most intriguing contributions have been in the area of pediatric renal a nd genitourinary pathology. This review focuses on the entities in these organ systems where he has focused his efforts: malignant rhabdoid tumor, renal medullary carcinoma, Ewing sarcoma/peripheral neuroectodermal tumor, and the DICER1-related lesions cystic nephroma, embryonal rhabdomyosarcoma of the uterine cervix,...
Source: Seminars in Diagnostic Pathology - August 30, 2016 Category: Pathology Authors: Jason A. Jarzembowski Source Type: research
Inflammatory myofibroblastic tumour
The past twenty years have seen a profound evolution in our understanding of inflammatory myofibroblastic tumours (IMT). In the 1990 ′s, IMT as we now recognise it, was still lost amidst the noise of inflammatory pseudotumours, an umbrella term that encompassed an array of infectious, reactive and reparative processes.1 However, astute clinico-pathologic observation, led by Pepper Dehner and colleagues, suggested that, in the m idst of this confusing melee, a discrete subset existed that could be defined as true myofibroblastic neoplasms, despite the presence of a conspicuous inflammatory background. (Source: Seminars in...
Source: Seminars in Diagnostic Pathology - August 30, 2016 Category: Pathology Authors: Michael McDermott Source Type: research
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(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - August 25, 2016 Category: Pathology Source Type: research
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(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - August 25, 2016 Category: Pathology Source Type: research
