Introduction
I have three favorite books in general pathology, two of which I've had since they were first published. One of them is the Pathology of Pseudoneoplastic Lesions.1 Everyone else in my office has come in periodically over the years to borrow it, because as pathologists we deal with these issues on a regular basis. The articles in this edition of the journal look at some of the pseudoneoplastic lesions with which pathologists have to deal, some of them frequent, some of them only occasional. The organ systems covered are a somewhat eclectic mix, as bone, gynecologic, skin, and hematologic pseudoneoplasms have seen some cover...
Source: Seminars in Diagnostic Pathology - September 8, 2015 Category: Pathology Source Type: research
Pseudoneoplasms in the nervous system
A large range of common entities in the central and peripheral nervous systems simulate neoplasms. These include infectious/inflammatory, demyelinating, vascular and developmental lesions. Demyelinating disease even has its own terminology for tumor-like lesions (tumefactive). It is always a good idea to know what the radiologic studies show, as this takes the place of the gross examination you are used to in other organ systems. In these days of electronic medical records, you frequently can see the imaging for yourself and read the report. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - September 8, 2015 Category: Pathology Authors: Cynthia T. Welsh Source Type: research
Benign Soft Tissue Lesions That May Mimic Malignancy
Imitations of malignancy are abundant in the arena of soft tissue pathology, and can represent a significant diagnostic challenge for clinicians, radiologists, and pathologists alike. Not only may benign conditions mimic malignancy, but focal areas of malignant entities may mimic benignancy. Clinically these pseudoneoplastic lesions may simulate a sarcoma as a mass forming lesion, in some cases with aggressive local behavior and rapid growth, which is worrisome to the patient and clinician. Histologically, benign soft tissue neoplasms may have microscopic features overlapping with malignant soft tissue tumors, namely incre...
Source: Seminars in Diagnostic Pathology - September 8, 2015 Category: Pathology Authors: Jessica A. Forcucci, Evelyn T. Bruner, M. Timothy Smith Source Type: research
Familiar and Unfamiliar Pseudoneoplastic LESIONS of the head and neck
A number of lesions that occur in the head and neck may simulate malignancy if only a single perspective of radiographic or clinical or pathologic examination is used to assess the lesion. A multidisciplinary approach, in some situations, will be vital to integrating information that enables the correct assessment of the process. The purpose of this article is to provide a brief overview of a narrow set of challenging and unusual entities, some unique to the head and neck region. These entities may be encountered by a surgical pathology service in a variety of settings including at the time of intraoperative consultation. ...
Source: Seminars in Diagnostic Pathology - September 7, 2015 Category: Pathology Authors: Mary S. Richardson Source Type: research
Non-Neoplastic Pancreatic Lesions that may Mimic Malignancy
The widespread use of abdominal ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) has resulted in increased identification of asymptomatic pancreatic lesions; the so called “incidentalomas”.1 Preoperative diagnoses of pancreatic lesions can be difficult. Solid and cystic lesions and anatomic variants of normal can all mimic tumor clinically and radiologically.2 The addition of fine needle aspiration to endoscopic ultrasound (EUS-FNA) has become a mainstay in the diagnosis of pancreatic lesions, improving our ability to diagnose many lesions, however due to contamination by gastrointestinal...
Source: Seminars in Diagnostic Pathology - September 7, 2015 Category: Pathology Authors: Sherry D. Okun, David N. Lewin Source Type: research
Pseudotumors Of The Placenta
The placenta is one of the most common gross pathology specimens encountered by surgical pathologists, yet primary tumors are exceptionally rare. Occasionally, one may encounter an entity with the potential to mimic malignancy; however, there are numerous non-neoplastic mass forming lesions that may be observed in the placenta, and, less frequently, in the placental membranes and umbilical cord that are important to be aware of. Although many of these are unlikely to be confused with a tumor after thorough gross and microscopic examination, it is important to make the appropriate diagnosis of these lesions as many are clin...
Source: Seminars in Diagnostic Pathology - September 7, 2015 Category: Pathology Authors: Evelyn T. Bruner Source Type: research
Benign mimickers of malignant breast lesions
Breast Pathology is filled with pitfalls, including under diagnosis of bland appearing lesions, both invasive and non-invasive, misdiagnosis of malignant lesions as belonging to the wrong subgroup, for example calling LCIS as DCIS or missing the metaplastic component of an invasive lesion, and over-diagnosis of benign lesions as malignancy. While each is a sin of varying severity, the over-diagnosis of benign lesions can be the most scarring, especially in this age where Angelina Jolie's prophylactic mastectomy is headline news and patients are pushing for aggressive preventative treatment. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - September 5, 2015 Category: Pathology Authors: Laura Spruill Source Type: research
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)
Diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH) is a pre-invasive generalized proliferation of pulmonary neuroendocrine (PNE) cells that has been described in combination with carcinoid tumorlets, obliterative bronchiolitis and other fibrotic lung changes. Since its first recognition as a distinct syndrome in 1992, variable clinico-pathologic features have been used to diagnose DIPNECH in small case series and case reports. We recently proposed the use of the following criteria for the pathologic diagnosis of the syndrome on lung resection specimens: presence of multifocal neuroendocrine cell hyperplasia, as d...
Source: Seminars in Diagnostic Pathology - September 1, 2015 Category: Pathology Authors: Alberto M. Marchevsky, Ann E. Walts Source Type: research
Hyperplasia of pulmonary neuroendocrine cells in infancy and childhood
Pulmonary neuroendocrine cells (PNEC) are widely distributed throughout the airway mucosa of mammalian lung as solitary cells and as distinctive innervated clusters, neuroepithelial bodies (NEB). These cells differentiate early during lung development and are more prominent in fetal/neonatal lungs compared to adults. PNEC/NEB cells produce biogenic amine (serotonin) and a variety of peptides (ie. bombesin) involved in regulation of lung function. During the perinatal period, NEB are thought to function as airway O2/CO2 sensors. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - August 29, 2015 Category: Pathology Authors: Ernest Cutz Source Type: research
Masthead
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Source: Seminars in Diagnostic Pathology - August 28, 2015 Category: Pathology Source Type: research
Editorial Board
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Source: Seminars in Diagnostic Pathology - August 28, 2015 Category: Pathology Source Type: research
Table of Contents
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Source: Seminars in Diagnostic Pathology - August 28, 2015 Category: Pathology Source Type: research
Topics
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Source: Seminars in Diagnostic Pathology - August 28, 2015 Category: Pathology Source Type: research
Cover
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Source: Seminars in Diagnostic Pathology - August 28, 2015 Category: Pathology Source Type: research
Immunohistochemistry 2015: Protein correlates of molecular alterations and predictive testing
For over a quarter of a century, immunohistochemistry has played an integral role in diagnostic surgical pathology. More than a thousand polyclonal and monoclonal antibodies directed against tumor-associated proteins have been introduced into clinical immunohistochemistry laboratories. In large part, these antigenic targets represent cell membranous, cytoplasmic, and nuclear proteins associated with particular differentiated cell types and are therefore relatively lineage restricted but with markedly variable specificities. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - July 16, 2015 Category: Pathology Authors: Jason L. Hornick Source Type: research
