Cutaneous EBV-related lymphoproliferative disorders
This article will focus on the cutaneous lymphoproliferative disorders associated with EBV, with an emphasis on the upcoming changes in the revised 4th Edition of the WHO classification of tumors of the hematopoietic system, many of which deal with cutaneous disorders derived from NK-cells or T-cells. Extranodal NK/T-cell lymphoma usually presents in the upper aerodigestive tract, but can involve the skin secondarily. EBV-associated T- and NK-cell lymphoproliferative disorders (LPD) in the pediatric age group include the systemic diseases, chronic active EBV infection (CAEBV) and systemic EBV+ T-cell lymphoma of childhood....
Source: Seminars in Diagnostic Pathology - December 5, 2016 Category: Pathology Authors: Alejandro A. Gru, Elaine S. Jaffe Source Type: research
Primary cutaneous B-cell lymphomas with large cell predominance –primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma
In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent two of the three most common types of primary cutaneous B-cell lymphoma recognized in the current WHO classification system.1,2 Overall, B-cell lymphomas represent 19 –27% of primary cutaneous lymphomas in most large European and American studies3–6 and together, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type acc...
Source: Seminars in Diagnostic Pathology - December 1, 2016 Category: Pathology Authors: Charity B. Hope, Laura B. Pincus Source Type: research
Primary cutaneous B-cell lymphomas with large cell predominance – primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma
In this review, we present clinical features and detailed histopathologic, immunologic, and molecular information regarding primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type which together represent two of the three most common types of primary cutaneous B-cell lymphoma recognized in the current WHO classification system.1,2 Overall, B-cell lymphomas represent 19 –27% of primary cutaneous lymphomas in most large European and American studies3–6 and together, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type acc...
Source: Seminars in Diagnostic Pathology - December 1, 2016 Category: Pathology Authors: Charity B. Hope, Laura B. Pincus Source Type: research
The Landscape of Cutaneous Lymphomas in 2016, an Introduction
The approach to the classification of cutaneous lymphomas has been challenged by the competing demands of an “organ-specific” approach vs. a desire to better understand common features of lymphomas affecting multiple anatomic sites1,2. For example, some lymphoma subtypes that may present in the skin as well as other anatomic sites, such as extranodal marginal zone lymphoma, share some histological and immunophenotypic features, but still differ in underlying biology and clinical behavior. Conversely, some lymphomas presenting primarily in the skin, such as adult T-cell leukemia/ lymphoma or intravascular large B-cell l...
Source: Seminars in Diagnostic Pathology - December 1, 2016 Category: Pathology Authors: Alejandro A Gru, Elaine S. Jaffe Source Type: research
A new era for cutaneous CD30-positive T-cell lymphoproliferative disorders
Cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ T-LPD) represent a spectrum encompassing lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL) and borderline lesions. They share the expression of CD30 as a common phenotypic marker. They differ however in their clinical presentation, the histological features and clinical course. Moreover, LyP and PcALCL show numerous clinical, histological and phenotypic variants. Overlapping features of LyP and pcALCL with themselves and with other cutaneous and systemic lymphomas emphasize the importance of careful clinicopathologic correlati...
Source: Seminars in Diagnostic Pathology - November 28, 2016 Category: Pathology Authors: Werner Kempf Source Type: research
Cutaneous Marginal Zone Lymphomas
Primary cutaneous marginal zone lymphoma (CMZL) is one of the major primary B-cell lymphomas of skin. Two types are recognized: a more common class-chain switched CMZL, and a much less common IgM+ CMZL. The extremely indolent course, together with other features distinct from most other MALT lymphomas, has led some to question whether at least the class-switched cases should be considered an overt lymphoma. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - November 28, 2016 Category: Pathology Authors: Steven H. Swerdlow Source Type: research
Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically
This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - November 28, 2016 Category: Pathology Authors: Mark R. Wick, Daniel J. Santa Cruz, Alejandro A. Gru Source Type: research
Cutaneous lymphomas with a panniculitic presentation
Subcutaneous panniculitis-like T-cell lymphoma and primary cutaneous gamma/delta T-cell lymphoma are the two most common types of cutaneous T-cell lymphoma presenting with panniculitis-like lesions. In this article the characteristic clinical, histological and immunophenotypical features of these conditions are reviewed and criteria to differentiate these tumors from other benign and malignant lymphoproliferations presenting with panniculitis-like lesions are discussed. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - November 28, 2016 Category: Pathology Authors: Rein Willemze Source Type: research
Past, present and future of cutaneous lymphomas
Primary cutaneous lymphomas represent a broad group of diseases with different clinical, histopathological, phenotypic, molecular, and prognostic features. All cutaneous lymphomas share the same tropism of neoplastic lymphocytes for the skin, but precise classification is paramount for proper management of the patients. Primary cutaneous lymphomas are classified according to the schemes proposed by the European Organization for Research and Treatment of Cancer (EORTC)-Cutaneous Lymphomas Task Force together with the World Health Organization (WHO) in 2005, and the WHO classification of 2008 with the 2016 update. (Source: S...
Source: Seminars in Diagnostic Pathology - November 27, 2016 Category: Pathology Authors: Lorenzo Cerroni Source Type: research
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Source: Seminars in Diagnostic Pathology - October 31, 2016 Category: Pathology Source Type: research
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Source: Seminars in Diagnostic Pathology - October 31, 2016 Category: Pathology Source Type: research
Editorial Board
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Source: Seminars in Diagnostic Pathology - October 31, 2016 Category: Pathology Source Type: research
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Source: Seminars in Diagnostic Pathology - October 31, 2016 Category: Pathology Source Type: research
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Source: Seminars in Diagnostic Pathology - October 31, 2016 Category: Pathology Source Type: research
Erratum to “Introduction” [Seminars in Diagnostic Pathology 33(5) (2016) 243]
The article “Introduction,” by Wick (Seminars in Diagnostic Pathology 2016;33(5):243), incorrectly states that Dr. Juan Rosai is a senior consulting pathologist for Genzyme Genetics. Dr. Rosai is currently consultant surgical pathologist with ARUP Laboratories and the Department of Pathology of the Universi ty of Utah Medical School. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - October 31, 2016 Category: Pathology Authors: Mark R. Wick Tags: Erratum Source Type: research
