Multicentric castleman disease: Where are we now?
Multicentric Castleman disease (MCD) encompasses a spectrum of conditions that give rise to overlapping clinicopathological manifestations. The fundamental pathogenetic mechanism involves dysregulated cytokine activity, which causes systemic inflammatory symptoms as well as lymphadenopathy. The histological changes in lymph nodes resemble in part the findings originally described in the unicentric forms Castleman disease, both hyaline vascular and plasma cell variants. In MCD caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/HHV8), the cytokine over activity is caused by viral products, which can al...
Source: Seminars in Diagnostic Pathology - May 15, 2016 Category: Pathology Authors: Hao-Wei Wang, Stefania Pittaluga, Elaine S. Jaffe Source Type: research
Introduction
The 20th century was notable for the development of many people and things, in several facets of life. Indeed, the evolution and progression of civilization in general was exponential during that time. In the field of medicine, developments were protean in nature between the years 1900 and 2000. They included the discovery of insulin, antibiotics, antihypertensives, and corticosteroids; the birth of modern anesthesia, transplantation medicine, and cardiothoracic surgery; the advent of increasingly sophisticated imaging techniques; availability of the first effective antineoplastic medications and several new antimicrobial ...
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Follicular dendritic cells and related sarcoma
Follicular dendritic cells are mesenchymal-derived dendritic cells located in the B follicles, where they capture, retain and present antigens to surrounding B cells, thus playing a pivotal role in triggering and maintaining B-cell adaptive immune response. The term follicular dendritic cells (FDC) was originally introduced by Steinman et al. in 1978. In 1986, Monda and Rosai first reported tumoral proliferations derived from FDC occurring in lymph nodes and the term FDC sarcoma was subsequently coined to identify this neoplasm. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Fabio Facchetti, Luisa Lorenzi Source Type: research
Mediastinal pathology and the contributions of Dr. Juan Rosai
Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark articles in this topical area, including articles on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Acinar neoplasms of the pancreas —A summary of 25 years of research
Our understanding about the family of acinar neoplasms of the pancreas has grown substantially over the past 25 years. The prototype is acinar cell carcinoma, an uncommon variant of pancreatic carcinoma that demonstrates production of pancreatic exocrine enzymes, verifiable using immunohistochemistry, and exhibits characteristic histologic features. Related neoplasms include mixed acinar carcinomas such as mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma. In the pediatric age group, pancreatoblastoma is also closely related. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: David S. Klimstra, Volkan Adsay Source Type: research
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions
Vascular proliferations in the skin have been thoroughly studied over the past 35 years, and a great deal of knowledge has been accrued regarding their pathobiological features. Dr. Juan Rosai has been a consistent contributor to the literature on this topic throughout most of his career, and this article reviews selected cutaneous endothelial lesions that he helped to characterize. They include histiocytoid-epithelioid hemangioma, targetoid-hobnail hemangioma, acquired tufted hemangioma, glomeruloid hemangioma, spindle cell hemangioma, retiform hemangioendothelioma, and angiosarcoma. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Mediastinal pathology and the contributions of Dr. Juan Rosai
Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark articles in this topical area, including articles on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic langerhans-cell histiocytosis, mediastinal germ cell neoplasms, and multilocular thymic cyst. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Acinar neoplasms of the pancreas —A summary of 25 years of research
Our understanding about the family of acinar neoplasms of the pancreas has grown substantially over the past 25 years. The prototype is acinar cell carcinoma, an uncommon variant of pancreatic carcinoma that demonstrates production of pancreatic exocrine enzymes, verifiable using immunohistochemistry, and exhibits characteristic histologic features. Related neoplasms include mixed acinar carcinomas such as mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma. In the pediatric age group, pancreatoblastoma is also closely related. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: David S. Klimstra, Volkan Adsay Source Type: research
Acinar neoplasms of the pancreas—A summary of 25 years of research
Our understanding about the family of acinar neoplasms of the pancreas has grown substantially over the past 25 years. The prototype is acinar cell carcinoma, an uncommon variant of pancreatic carcinoma that demonstrates production of pancreatic exocrine enzymes, verifiable using immunohistochemistry, and exhibits characteristic histologic features. Related neoplasms include mixed acinar carcinomas such as mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma. In the pediatric age group, pancreatoblastoma is also closely related. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: David S. Klimstra, Volkan Adsay Source Type: research
Introduction
The twentieth century was notable for the development of many people and things, in several facets of life. indeed, the evolution and progression of civilization in general was exponential during that time. in the field of medicine, developments were protean in nature between the years 1900 and 2000. they included the discovery of insulin, antibiotics, antihypertensives, and corticosteroids; the birth of modern anesthesia, transplantation medicine, and cardiothoracic surgery; the advent of increasingly sophisticated imaging techniques; availability of the first effective antineoplastic medications and several new antimicro...
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Follicular dendritic cells and related sarcoma
Follicular Dendritic Cells (FDC) are mesenchymal-derived dendritic cells located in the B follicles, where they capture, retain and present antigens to surrounding B cells.1 They have been originally discovered by Alexander Maximow 2 in human lymph nodes and defined as “embryonal non-phagocytic reticulum cells” occurring in B follicles. Electron microscopic features 3–6 subsequently prompted to define them “antigen-retaining reticulum of lymph node follicles” 6 or simply “reticular cells”.5 The term follicular dendritic cells (FDC) was introduced by Steinman et al. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Fabio Facchetti, Luisa Lorenzi Source Type: research
Mediastinal pathology & the contributions of Dr. Juan Rosai
Dr. Juan Rosai is one of the most prolific contributors to the literature on mediastinal pathology, and he has added steadily to that body of work over a 50-year period. Rosai has written several landmark papers in this topical area, including manuscripts on thymic epithelial lesions, mediastinal neuroendocrine tumors, mediastinal lymphoma and other hematopoietic lesions, thymolipoma, thymoliposarcoma, mediastinal solitary fibrous tumor, intrathymic Langerhans-cell histiocytosis, mediastinal germ-cell neoplasms, and multilocular thymic cyst. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
Acinar neoplasms of the pancreas. A summary of twenty-five years of research
Our understanding about the family of acinar neoplasms of the pancreas has grown substantially over the past twenty-five years. The prototype is acinar cell carcinoma, an uncommon variant of pancreatic carcinoma that demonstrates production of pancreatic exocrine enzymes, verifiable using immunohistochemistry, and exhibits characteristic histologic features. Related neoplasms include mixed acinar carcinomas such as mixed acinar neuroendocrine carcinoma and mixed acinar ductal carcinoma. In the pediatric age group, pancreatoblastoma is also closely related. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: David S. Klimstra, Volkan Adsay Source Type: research
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions
Vascular proliferations in the skin have been thoroughly studied over the past 35 years, and a great deal of knowledge has been accrued regarding their pathobiological features. Dr. Juan Rosai has been a consistent contributor to the literature on this topic throughout most of his career, and this paper reviews selected cutaneous endothelial lesions that he helped to characterize. They include histiocytoid-epithelioid hemangioma, targetoid-hobnail hemangioma, acquired tufted hemangioma, glomeruloid hemangioma, spindle-cell hemangioma, retiform hemangioendothelioma, and angiosarcoma. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Mark R. Wick Source Type: research
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(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - April 28, 2016 Category: Pathology Source Type: research
