Follicular dendritic cells and related sarcoma

Follicular Dendritic Cells (FDC) are mesenchymal-derived dendritic cells located in the B follicles, where they capture, retain and present antigens to surrounding B cells.1 They have been originally discovered by Alexander Maximow 2 in human lymph nodes and defined as “embryonal non-phagocytic reticulum cells” occurring in B follicles. Electron microscopic features 3–6 subsequently prompted to define them “antigen-retaining reticulum of lymph node follicles” 6 or simply “reticular cells”.5 The term follicular dendritic cells (FDC) was introduced by Steinman et al.

Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Fabio Facchetti, Luisa Lorenzi Source Type: research