Follicular dendritic cells and related sarcoma

Follicular dendritic cells are mesenchymal-derived dendritic cells located in the B follicles, where they capture, retain and present antigens to surrounding B cells, thus playing a pivotal role in triggering and maintaining B-cell adaptive immune response. The term follicular dendritic cells (FDC) was originally introduced by Steinman et al. in 1978. In 1986, Monda and Rosai first reported tumoral proliferations derived from FDC occurring in lymph nodes and the term FDC sarcoma was subsequently coined to identify this neoplasm.

Source: Seminars in Diagnostic Pathology - May 12, 2016 Category: Pathology Authors: Fabio Facchetti, Luisa Lorenzi Source Type: research