Editorial Board
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - March 1, 2015 Category: Pathology Source Type: research
Table of Contents
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - March 1, 2015 Category: Pathology Source Type: research
Cover
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - March 1, 2015 Category: Pathology Source Type: research
The pathology of HPV-related head and neck Cancer: Implications for the diagnostic pathologist
A subset of head and neck squamous cell carcinoma are caused by the human papillomavirus (HPV). This HPV-related form of head and neck squamous cell carcinoma (HPV-HNSCC) has captured the attention of the oncology community for its rising incidence, its link to non-traditional risk factors, and its divergent clinical behavior. To diagnose this special form of head and neck squamous cell carcinoma is to provide important prognostic information and, in some instances, redirect clinical therapy. The diagnosis of HPV-HNSCC is aided by a strong appreciation for its characteristic microscopic findings and by an awareness of aber...
Source: Seminars in Diagnostic Pathology - February 28, 2015 Category: Pathology Authors: William H. Westra Source Type: research
Nasopharyngeal carcinoma: A review
Nasopharyngeal carcinoma is an umbrella term for a group of malignant epithelial tumors with different etiopathogenesis and a broad range of histopathological appearances. Some types have a dramatically skewed geographical and ethnic distribution and shows virtually 100% association with Epstein Barr virus. The field of other/contributing etiological factors are only partially known and recently a subset of this carcinoma has been linked to transcriptionally active Human Papilloma virus. As with all malignant tumors, the clinical stage of disease is of paramount importance. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 25, 2015 Category: Pathology Authors: Fredrik Petersson Source Type: research
Nasopharyngeal carcinoma – A review
Globally, there are approximately 80,000 new cases of nasopharyngeal carcinoma (NPC) per annum and circa 50,000 patients die from this neoplasm annually. The first series of patients with NPC was published in 1901 and comprised 14 patients.1 A subsequent and larger study was published in 1922 and comprised 79 patients2, followed by a large and comprehensive study in 1941 of the clinicopathologic features in 114 patients.3 Currently WHO classifies nasopharyngeal carcinoma (NPC) into keratinizing (K) carcinoma (squamous cell carcinoma – SCC), non-keratinizing (NK) carcinoma, including differentiated and undifferentiated va...
Source: Seminars in Diagnostic Pathology - February 25, 2015 Category: Pathology Authors: Fredrik Petersson Source Type: research
PEComas of the kidney and of the genitourinary tract
PEComas are mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells which are characterized by the coexpression of muscle and melanogenesis markers. This group of lesions includes angiomyolipoma, clear-cell “sugar” tumor of the lung and extrapulmonary sites, lymphangioleiomyomatosis, clear-cell myomelanocytic tumor of the falciform ligament/ligamentum teres and rare clear-cell tumors of other anatomical sites. In the genitourinary tract PEComas have been described in the kidney, bladder, prostate, testis and urethra. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 24, 2015 Category: Pathology Authors: Guido Martignoni, Maurizio Pea, Claudia Zampini, Matteo Brunelli, Diego Segala, Giuseppe Zamboni, Franco Bonetti Source Type: research
Editorial
Viral-Related Diseases of the Head and Neck (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 24, 2015 Category: Pathology Authors: Bruce M. Wenig Source Type: research
Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma Variants
During the last few decades a phenotypically distinct type of head and neck squamous cell carcinoma (SCC), that is etiologically related to human papillomavirus(HPV), has emerged and its prevalence continues to increase. The tumors are site-specific with special predilection for the oropharynx. They are morphologically and molecularly distinct and are responsive to different types of treatment modalities, with excellent clinical outcome, in spite of early lymph node metastasis. Microscopically, the carcinomas are nonkeratinizing SCCs. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 24, 2015 Category: Pathology Authors: Samir K. El-Mofty Source Type: research
Papillary or Pseudopapillary Tumors of the Kidney
This article reviews all the renal cell neoplasms with papillary or pseudopapillary architecture with an emphasis on recently described new histological types. New insights into the “old” entities, including their immunohistochemical and genetic features, will also be discussed. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 23, 2015 Category: Pathology Authors: Fang-Ming Deng, Max X. Kong, Ming Zhou Source Type: research
Epstein-barr virus (EBV)-associated lymphoid lesions of the head and neck
Epstein Barr virus (EBV) is a ubiquitous herpes virus (formally human herpes virus 4) that infects more than 90% of adults worldwide. In the United States, it is estimated that greater than 80% of individuals by age 19 are seropositive for EBV. 1 EBV is generally transferred though saliva. Primary infection can occur throughout life. If the primary infection occurs early in life, there may be few or no symptoms; however, if the primary infection occurs later symptoms of infectious mononucleosis may occur. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 5, 2015 Category: Pathology Authors: Aaron Auerbach, Nadine Aguilera Source Type: research
Cytologic Mimics of Non-Hodgkin Lymphoma in the Head and Neck
A myriad of non-lymphoid small ‘rounded cell’ malignancies can present as apparent non-Hodgkin lymphoma (NHL) in head/neck fine needle aspiration (FNA) biopsy specimens. Included in this category are HPV-related neoplasms which may mimic NHL, particularly when they metastasize to lymph nodes. Due to the nondescript cytomorphology of these malignant small ‘rounded’ cells, ancillary testing, particularly immunohistochemical (IHC) staining of a cell-block is often critical for a specific diagnosis. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 5, 2015 Category: Pathology Authors: Lourdes R. Ylagan Source Type: research
Introduction
In marked contrast to surgical pathology, routine use of fine needle aspiration cytopathology (FNAC) as a diagnostic tool has been in practice in the U.S. for little more than three decades. Yet, this technique is now indispensable in many clinical situations. Arguably, lesions involving the head and neck (H/N) region are one of the more common sites where this technique is applied. Thus, our decision to dedicate an issue of Seminars in Diagnostic Pathology to some of the recent advances in the cytopathology of this region. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 4, 2015 Category: Pathology Authors: P.E. Wakely Source Type: research
Renal neoplasia: From morphologic to molecular diagnosis
Although the first confirmed case of renal carcinoma was diagnosed more than 200 years ago, it is only over the last few decades that we have gained some understanding of the breadth and depth of renal neoplasia.1,2 Variants of renal cell neoplasia are frequently referred to as morphotypes on the basis that they can be differentiated from each other on histological appearances. While this still holds for the majority renal carcinomas, increasing numbers of tumors are being described where genetic studies are required for diagnostic confirmation. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 4, 2015 Category: Pathology Authors: Brett Delahunt, John R Srigley Source Type: research
The evolving classification of renal cell neoplasia
Renal cell neoplasms are tumors derived from the epithelial components of the nephron and are the most commonly encountered tumors of the upper urinary tract. Although the earliest confirmed case of renal carcinoma was reported over 200 years ago,1 it is only over the past 30 years that our understanding that renal cell tumors represent a morphologic spectrum of tumors that differ in architecture, genetics and clinical behaviour.2 (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - February 4, 2015 Category: Pathology Authors: Brett Delahunt, John R. Srigley Source Type: research
