Immunohistochemistry 2015: Protein correlates of molecular alterations and predictive testing

For over a quarter of a century, immunohistochemistry has played an integral role in diagnostic surgical pathology. More than a thousand polyclonal and monoclonal antibodies directed against tumor-associated proteins have been introduced into clinical immunohistochemistry laboratories. In large part, these antigenic targets represent cell membranous, cytoplasmic, and nuclear proteins associated with particular differentiated cell types and are therefore relatively lineage restricted but with markedly variable specificities.

Source: Seminars in Diagnostic Pathology - July 16, 2015 Category: Pathology Authors: Jason L. Hornick Source Type: research