Rosai-dorfman disease: Familiar yet enigmatic

The disorder known as “Sinus histiocytosis with massive lymphadenopathy” was originally described by Destombes in 1965as “Adenitis with lipid excess.”1 However, it fell to Rosai and Dorfman in 1969 and 1972 to delineate this as a distinct entity and characterize its clinical and pathologic features.2,3 Since extranodal manifestations are common, and lymph nodes are not always involved, the eponymous designation of “Rosai-Dorfman disease (RDD)” is preferred in most of the world (and as Destombes-Rosai-Dorfman disease in France).
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research