Diagnostic electron microscopy & the influence of Dr. Juan rosai

Transmission electron microscopy (TEM ) was introduced by Ruska & Knoll as a laboratory technique in 1933. Thereafter, several decades passed before the methods required for its optimal implementation were fully developed. Early uses of TEM were in Botany, rather than in Medicine; however, isolated publications did catalogue the ultrastructural characteristics of several individual human tumor types. Finally, in 1968, Rosai & Rodriguez authored an important paper, introducing the concept that TEM could be used for the differential diagnosis of histologically-similar neoplasms.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research