Prostaglandins and Other Lipid Mediators This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Oxidative pathways of arachidonic acid as targets for regulation of platelet activation
Publication date: Available online 18 October 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Andrés Trostchansky, Rodrigo Moore-Carrasco, Eduardo FuentesAbstractPlatelet activation plays an important role in acute and chronic cardiovascular disease states. Multiple pathways contribute to platelet activation including those dependent upon arachidonic acid. Arachidonic acid is released from the platelet membrane by phospholipase A2 action and is then metabolized in the cytosol by specific arachidonic acid oxidation enzymes including prostaglandin H synthase, 12-lipoxygenase, and cytochrome P450 to produce pro-...
Source: Prostaglandins and Other Lipid Mediators - October 19, 2019 Category: Lipidology Source Type: research

Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock
Publication date: Available online 3 October 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Bahar Tunctan, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Demet Sinem Guden, Seyhan Sahan-Firat, John R. Falck, Kafait U. MalikAbstractSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock, the most common form of vasodilatory shock, is a subset of sepsis in which circulatory and cellular/metabolic abnormalities are severe enough to increase mortality. Inflammatory shock constitutes the hallmark of sepsis, but also a final common pathway of any form of severe ...
Source: Prostaglandins and Other Lipid Mediators - October 5, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: October 2019Source: Prostaglandins & Other Lipid Mediators, Volume 144Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - October 1, 2019 Category: Lipidology Source Type: research

Urinary prostaglandin D2 and E2 metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects
Publication date: Available online 13 August 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sven-Christian Pawelzik, Antoine Avignon, Helena Idborg, Catherine Boegner, Françoise Stanke-Labesque, Per-Johan Jakobsson, Ariane Sultan, Magnus BäckAbstractObesity is associated with low-grade chronic inflammation, which contributes to the development of the metabolic syndrome and its associated complications, such as insulin resistance and type-2 diabetes. There is limited data from animal and human studies about the local generation of pro-inflammatory prostanoid lipid mediators in white adipose tissue. However, ...
Source: Prostaglandins and Other Lipid Mediators - August 14, 2019 Category: Lipidology Source Type: research

The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects
This study demonstrated that S1P significantly promotes angiogenesis, inflammation, and barrier integrity, which was attenuated by inhibition of S1P2 or S1P3, suggesting that regulation of S1P2 and S1P3 is a novel therapeutic target for CNV.Graphical abstract (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - August 13, 2019 Category: Lipidology Source Type: research

Evaluation of Analgesic and Antiplatelet Activity of 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid
Publication date: Available online 26 July 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Caroline, Kuncoro Foe, Senny Yesery Esar, Ami Soewandi, Hevi Wihadmadyatami, Ratna Megawati Widharna, Wahyu Dewi Tamayanti, Elisabeth Kasih, Yudy TjahjonoAbstractsAcetylsalicylic acid is used as a non-steroidal anti-inflammatory drugs (NSAID) and antiplatelet agents by inhibiting cyclooxygenases. However, therapy using acetylsalicylic acid could induce gastric bleeding and cause other gastrointestinal toxicity. The aim of this study was to demonstrate the synthesis of a new compound bearing salicylic acid residue namely ...
Source: Prostaglandins and Other Lipid Mediators - July 27, 2019 Category: Lipidology Source Type: research

Liquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acids
Publication date: Available online 16 July 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Stefanie Liening, Erik Romp, Oliver Werz, Gerhard Scriba, Ulrike GarschaAbstractGlutathione (GSH) conjugates of oxygenated polyunsaturated fatty acids comprise a group of pro-inflammatory and pro-resolving lipid mediators formed in immunocompetent cells. While the pro-inflammatory conjugates as the cysteinyl leukotrienes (cys-LTs), eoxins (EXs) and five-oxo-GSH conjugate (FOG7) derive from arachidonic acid (AA), the group of conjugates in tissue regeneration (CTRs) such as maresin CTRs (MCTRs), protectin CTRs (PCTRs) and...
Source: Prostaglandins and Other Lipid Mediators - July 17, 2019 Category: Lipidology Source Type: research

Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism
Publication date: Available online 12 July 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Hiroshi Kuwata, Shuntaro HaraAbstractThe activation of long-chain free fatty acids is the first step reaction of their usage in the cells and tissues, which are catalyzed by a family of enzymes called acyl-coenzyme A synthetases long-chain isoform (ACSL). The five ACSL enzymes identified in mammals are thought to have specific and differing functions. Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an...
Source: Prostaglandins and Other Lipid Mediators - July 13, 2019 Category: Lipidology Source Type: research

Increased pain and inflammatory sensitivity in growth hormone-releasing hormone (GHRH) knockout mice
Publication date: Available online 10 July 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sheila Leone, Annalisa Chiavaroli, Lucia Recinella, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi, Irene Gasparo, Alessandra Bitto, Roberto Salvatori, Luigi BrunettiAbstractGrowth hormone (GH) and GH-releasing hormone (GHRH), in addition to metabolic and endocrine effects, play a role in the modulation of pain and inflammation. We aimed to elucidate the consequences of GHRH deficiency on acute nociceptive stimulation and on both acute and chronic inflammatory stimuli in a mouse model of GH deficiency. Mice wit...
Source: Prostaglandins and Other Lipid Mediators - July 11, 2019 Category: Lipidology Source Type: research

5-oxo-ETE activates migration of H295R adrenocortical cells via MAPK and PKC pathways
In this study we analyzed the effects of the OXE receptor physiological activator 5-oxo-ETE on the growth and migration of H259R cells. While 5-oxo-ETE did not affect the growth of H295R cells, overexpression of OXE receptor caused an increase in cell proliferation, which was further increased by 5-oxo-ETE and blocked by 5-lipoxygenase inhibition. 5-oxo-ETE increased the migratory capacity of H295R cells in wound healing assays, but it did not induce the production of metalloproteases MMP-1, MMP-2, MMP-9 and MMP-10. The pro-migratory effect of 5-oxo-ETE was reduced by pharmacological inhibition of the MEK/ERK1/2, p38 and P...
Source: Prostaglandins and Other Lipid Mediators - July 11, 2019 Category: Lipidology Source Type: research

Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus
ConclusionOur data reveal that chain-length specific ceramides in blood, most likely C24:1Cer levels in serum, could act as potent biomarkers for renal impairment in patients suffering from SLE. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 11, 2019 Category: Lipidology Source Type: research

Relation of oxidized-low-density lipoprotein and high-density lipoprotein subfractions in non-treated patients with coronary artery disease
ConclusionsThe correlations between ox-LDL and cholesterol level of large HDL particles varied among CAD and non-CAD, and CAD with different severities of atherosclerosis. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 4, 2019 Category: Lipidology Source Type: research

The effect of the ep3 antagonist dg-041 on male mice with diet-induced obesity
ConclusionShort term EP3 administration of DG-041 produced effective blockade of the EP3 receptor and decreased skeletal muscle triglyceride content but had no significant effects on the diabetic phenotype. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 3, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: August 2019Source: Prostaglandins & Other Lipid Mediators, Volume 143Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 3, 2019 Category: Lipidology Source Type: research

Oxylipin profiling in endothelial cells in vitro – Effects of DHA and hydrocortisone upon an inflammatory challenge
Publication date: Available online 28 June 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): A.C. Motta, K. Strassburg, P. Oranje, R.J. Vreeken, D.M. JacobsAbstractOmega-3 poly-unsaturated fatty acids have been shown to have beneficial effects on several inflammatory-driven endpoints such as cardiovascular diseases. The anti-inflammatory effects of docosahexaenoic acid (DHA) are largely mediated through various oxylipins. Yet, mechanistic insights are limited. Here, we measured 53 oxylipins using LC-MS/MS in an in vitro model of endothelial cell inflammation, and compared the changes induced by DHA to hydrocorti...
Source: Prostaglandins and Other Lipid Mediators - June 30, 2019 Category: Lipidology Source Type: research