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An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats
ConclusionInhibition of the sEH alleviates diabetes-induced decline in learning and memory. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice
The objective of this study was to characterize the time course of 12LO isoform expression and metabolite production in pancreatic islets and AT of C57BLKS/J-db/db obese diabetic mouse in a pre-diabetic state in order to establish a suitable therapeutic window for intervention with selective lipoxygenase inhibitors.Mice have 2 major 12LO isoforms –the leukocyte type (12/15LO) and the platelet type (p12LO) and both are expressed in islets and AT. We found a sharp increase in protein expression of 12/15LO in the pancreatic islets of 10-week old db-/- mice compared to 8- week old counterparts. Immunohistochemistry showed th...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Physiological response to central and peripheral injection of prostaglandin D2 in chicks
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Tetsuya Tachibana, Yasua Nakai, Ryosuke Makino, Md. Sakirul Islam Khan, Mark A. ClineAbstractProstaglandin D2 (PGD2) is associated with a diverse array of functions in mammals including regulation of appetite, body temperature, sleep, and immune responses. Although much is known about the effects of PGD2 in mammals, there is a lack of information about its effects in birds. Therefore, the purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injections of PGD2 affect feeding, vol...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Karan Agrawal, Rémy Bosviel, Brian D. Piccolo, John W. NewmanAbstractSweat contains a variety of lipid mediators, but whether they originate from the plasma filtrate or from the cutaneous sweat glandular tissues themselves is unknown. To explore this knowledge gap, we collected plasma and sweat from healthy men (n = 9) immediately before and 0.5, 2 and 4 h after oral administration of 400 mg ibuprofen. Of the over 100 lipid mediators assayed by liquid chromatography-tandem mass spectrometry, ∼45 were detected in both ...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Fen Xu, Xiaoyan Zhou, Jian Hao, Hua Dai, Jian Zhang, Yuanqiao He, Hua HaoAbstractEpithelial-mesenchymal Transition (EMT) and migration play an important role in tumor progression, and lipoxin (LX), the ‘stop signal’ for inflammation, has been studied in basic research for its anti-inflammatory or inflammatory pro-resolving properties. Here, in the in vitro experiment, we showed that LXA4 could inhibit the EMT and migration in phorbol myristate acetate (PMA) or activated conditioned medium (ACM)-stimulated Hep3B cells by down...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Johan Kolmert, Sergio Piñeiro-Hermida, Mats Hamberg, Joshua A. Gregory, Icíar P. López, Alexander Fauland, Craig E. Wheelock, Sven-Erik Dahlén, José G. Pichel, Mikael AdnerAbstractThe profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation remains unclear. This experimental study quantified metabolite levels of ω3-, ω6- and ω9-derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of repeated house dust mite (HDM) exposure in a murine (C57BL/6) asthma model...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P. Singh, David Bamshad, John A. McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T. Stier, Nader G. AbrahamAbstractBackgroundWe have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on renal and adipose tissue function, in addition to its vasodilatory action; it increases insulin sensitivity and inhibits inflammation. In an examination of the signaling mechanisms by which EET reduces renal and peri-renal fat function, we hyp...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Drawing a link between the thromboxane A2 pathway and the role of platelets and tumor cells in ovarian cancer
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Karolina Serhan, Allison Gartung, Dipak PanigrahyAbstractOvarian cancer is the most lethal gynecologic malignancy among women. Due to the heterogeneity and complexity of the disease, as well as the insidious onset of symptoms, timely diagnosis remains extremely challenging. Despite recent advances in chemotherapy regimens for ovarian cancer patients, many still suffer from recurrence and ultimately succumb to the disease; thus, there is an urgent need for the identification of novel therapeutic targets. Within this rapidly evolv...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

The prostanoid pathway contains potential prognostic markers for glioblastoma
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Alexandros Theodoros Panagopoulos, Renata Nascimento Gomes, Fernando Gonçalves Almeida, Felipe da Costa Souza, José Carlos Esteves Veiga, Anna Nicolaou, Alison ColquhounAbstractProstanoids derived from the activity of cyclooxygenases and their respective synthases contribute to both active inflammation and immune response in the tumor microenvironment. Their synthesis, deactivation and role in glioma biology have not yet been fully explored and require further study. Using quantitative real time PCR, gas chromatography/ electr...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

The contribution of TRPV1 channel to 20-HETE–aggravated ischemic neuronal injury
Publication date: Available online 6 July 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Xiaofan Zhang, Nagat El Demerdash, John R. Falck, Sailu Munnuri, Raymond C. Koehler, Zeng-Jin YangABSTRACT20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 (CYP) 4 A/4F-derived metabolite of arachidonic acid, directly contributes to ischemic neuronal injury. However, little is known about mediators of 20-HETE neurotoxicity after ischemia. Here, we focus on the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) in 20-HETE-induced neurotoxicity. Our results showed that TRPV1 and CY...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Different administration patterns of docosahexaenoic acid in combating cytotoxic manifestations due to arsenic trioxide (acute promyelocytic leukemia drug) induced redox imbalance in hepatocytes
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): S Abhilash, R Siviyasankar, P Binu, P Arathi, R Harikumaran NairAbstractDocosahexaenoic acid (DHA) obtained from fish and plant sources is an essential dietary fatty acid and an important cell membrane structural component. The acute promyelocytic leukemia (APL) drug arsenic trioxide (As2O3), causes hepatotoxicity. We evaluated the protective potential of DHA as pre/combination/post-administration patterns against As2O3 induced toxicity. The therapeutic concentration of As2O3 (10 μM) resulted in cytotoxicity with a significant...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease
Conclusionn-3 FA supplementation in patients with CKD leads to increased neutrophil release of LTB5 and several SPM, as well as a reduction in plasma MPO that may have important implications for limiting chronic inflammation. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression
ConclusionOur data suggest that the increase in EET levels may be part of a protective mechanism in ulcerative colitis. Furthermore, the concentration of EETs could be a key factor for drug therapy for ulcerative colitis. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research