Prostaglandins and Other Lipid Mediators This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The prostanoid pathway contains potential prognostic markers for glioblastoma
Publication date: Available online 30 June 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Alexandros Theodoros Panagopoulos, Renata Nascimento Gomes, Fernando Gonçalves Almeida, Felipe da Costa Souza, José Carlos Esteves Veiga, Anna Nicolaou, Alison Colquhoun Prostanoids derived from the activity of cyclooxygenases and their respective synthases contribute to both active inflammation and immune response in the tumor microenvironment. Their synthesis, deactivation and role in glioma biology have not yet been fully explored and require further study. Using quantitative real time PCR, gas chr...
Source: Prostaglandins and Other Lipid Mediators - June 30, 2018 Category: Lipidology Source Type: research

Physiological response to central and peripheral injection of prostaglandin D2 in chicks
Publication date: Available online 21 June 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Tetsuya Tachibana, Yasua Nakai, Ryosuke Makino, Md. Sakirul Islam Khan, Mark A. Cline Prostaglandin D2 (PGD2) is associated with a diverse array of functions in mammals including regulation of appetite, body temperature, sleep, and immune responses. Although much is known about the effects of PGD2 in mammals, there is a lack of information about its effects in birds. Therefore, the purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injections of PGD2 af...
Source: Prostaglandins and Other Lipid Mediators - June 22, 2018 Category: Lipidology Source Type: research

Drawing a link between the thromboxane A2 pathway and the role of platelets and tumor cells in ovarian cancer
Publication date: Available online 19 June 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Karolina Serhan, Allison Gartung, Dipak Panigrahy Ovarian cancer is the most lethal gynecologic malignancy among women. Due to the heterogeneity and complexity of the disease, as well as the insidious onset of symptoms, timely diagnosis remains extremely challenging. Despite recent advances in chemotherapy regimens for ovarian cancer patients, many still suffer from recurrence and ultimately succumb to the disease; thus, there is an urgent need for the identification of novel therapeutic targets. Within thi...
Source: Prostaglandins and Other Lipid Mediators - June 20, 2018 Category: Lipidology Source Type: research

EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter
Publication date: July 2018 Source:Prostaglandins & Other Lipid Mediators, Volume 137 Author(s): Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P. Singh, David Bamshad, John A. McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T. Stier, Nader G. Abraham Background We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on renal and adipose tissue function, in addition to its vasodilatory action; it increases insulin sensitivity and inhibits inflammation. In an examination of the signaling mechanisms by which EET reduces renal and peri-renal fat ...
Source: Prostaglandins and Other Lipid Mediators - June 3, 2018 Category: Lipidology Source Type: research

Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis
Publication date: Available online 19 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Fen Xu, Xiaoyan Zhou, Jian Hao, Hua Dai, Jian Zhang, Yuanqiao He, Hua Hao Epithelial-mesenchymal Transition (EMT) and migration play an important role in tumor progression, and lipoxin (LX), the ‘stop signal’ for inflammation, has been studied in basic research for its anti-inflammatory or inflammatory pro-resolving properties. Here, in the in vitro experiment, we showed that LXA4 could inhibit the EMT and migration in phorbol myristate acetate (PMA) or activated conditioned medium (ACM)-stimulated H...
Source: Prostaglandins and Other Lipid Mediators - May 19, 2018 Category: Lipidology Source Type: research

EET Enhances Renal Function in Obese Mice Resulting in Restoration of Mfn1/2 –HO-1 Signaling, and Decrease in Hypertension through Inhibition of Sodium Chloride Co-Transporter
Publication date: Available online 19 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P. Singh, David Bamshad, John A. McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T. Stier, Nader G. Abraham Background We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on renal and adipose tissue function, in addition to its vasodilatory action; it increases insulin sensitivity and inhibits inflammation. In an examination of the signaling mechanisms by which EET reduces renal and peri-ren...
Source: Prostaglandins and Other Lipid Mediators - May 19, 2018 Category: Lipidology Source Type: research

Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males
Publication date: Available online 17 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Karan Agrawal, Rémy Bosviel, Brian D. Piccolo, John W. Newman Sweat contains a variety of lipid mediators, but whether they originate from the plasma filtrate or from the cutaneous sweat glandular tissues themselves is unknown. To explore this knowledge gap, we collected plasma and sweat from healthy men (n = 9) immediately before and 0.5, 2 and 4 h after oral administration of 400 mg ibuprofen. Of the over 100 lipid mediators assayed by liquid chromatography-tandem mass spectrometry, ~45 were dete...
Source: Prostaglandins and Other Lipid Mediators - May 18, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid-derived Oxidized Lipid Metabolites Modulate the Inflammatory Response of Lipolysaccharide-stimulated Macrophages
Publication date: Available online 12 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): John P. Caron, Jeffrey C. Gandy, Jennifer L. Brown, Lorraine M. Sordillo Docosahexaenoic acid (DHA) supplementation has demonstrated beneficial effects in a number of inflammatory diseases. Increasingly, important contributions to its favorable effects are attributed downstream metabolites called docosanoids. Herein, we investigated the role of DHA-derived oxidized lipid metabolites on inflammatory mediator expression by RAW 264.7 murine macrophages. Specifically, macrophage incorporation of DHA, and the re...
Source: Prostaglandins and Other Lipid Mediators - May 12, 2018 Category: Lipidology Source Type: research

Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model
Publication date: Available online 12 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Johan Kolmert, Sergio Piñeiro-Hermida, Craig E. Wheelock, Mats Hamberg, Joshua A. Gregory, Icíar P. López, Alexander Fauland, Sven-Erik Dahlén, José G. Pichel, Mikael Adner The profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation remains unclear. This experimental study quantified metabolite levels of ω3-, ω6- and ω9-derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of repeated house dust mite (HDM) exposure in a murine (...
Source: Prostaglandins and Other Lipid Mediators - May 12, 2018 Category: Lipidology Source Type: research

Different administration patterns of docosahexaenoic acid in combating cytotoxic manifestations due to arsenic trioxide (acute promyelocytic leukemia drug) induced redox imbalance in hepatocytes
Publication date: Available online 8 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): S Abhilash, R Siviyasankar, P Binu, P Arathi, R Harikumaran Nair Docosahexaenoic acid (DHA) obtained from fish and plant sources is an essential dietary fatty acid and an important cell membrane structural component. The acute promyelocytic leukemia (APL) drug arsenic trioxide (As2O3), causes hepatotoxicity. We evaluated the protective potential of DHA as pre/ combination/ post-administration patterns against As2O3 induced toxicity. The therapeutic concentration of As2O3 (10 µM) resulted in cytotoxicity wi...
Source: Prostaglandins and Other Lipid Mediators - May 8, 2018 Category: Lipidology Source Type: research

Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway
Conclusion In conclusion, these results suggest that sustained presence of lipid inflammatory mediator LTD4 could induce human airway epithelial cell proliferation through ERK1/2 phosphorylation, either directly via CysLT1 receptor or by transactivating EGFR. Graphical abstract (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 8, 2018 Category: Lipidology Source Type: research

An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats
Conclusion Inhibition of the sEH alleviates diabetes-induced decline in learning and memory. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - May 8, 2018 Category: Lipidology Source Type: research

Sphingolipid signaling modulates trans-endothelial cell permeability in Dengue virus infected HMEC-1 cells
Publication date: Available online 4 May 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): M.G. Anupriya, Sneha Singh, Neha Vijay Hulyalkar, Easwaran Sreekumar Dengue has emerged as a major mosquito-borne disease in the tropics and subtropics. In severe dengue, enhanced microvascular endothelial permeability leads to plasma leakage. Direct dengue virus (DENV) infection in human microvascular endothelial cells (HMEC-1) can enhance trans-endothelial leakage. Using a microarray-based analysis, we identified modulation of key endothelial cell signaling pathways in DENV-infected HMEC-1 cells. One among...
Source: Prostaglandins and Other Lipid Mediators - May 4, 2018 Category: Lipidology Source Type: research

Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model
Publication date: Available online 13 April 2018 Source:Prostaglandins & Other Lipid Mediators Author(s): Shinji Toki, Weisong Zhou, Kasia Goleniewska, Sara Reiss, Daniel E. Dulek, Dawn C. Newcomb, William E. Lawson, R. Stokes Peebles Endogenous prostaglandin I2 (PGI2) has inhibitory effects on immune responses against pathogens or allergens; however, the immunomodulatory activity of endogenous PGI2 signaling in endotoxin-induced inflammation is unknown. To test the hypothesis that endogenous PGI2 down-regulates endotoxin-induced lung inflammation, C57BL/6 wild type (WT) and PGI2 receptor (IP) KO mice wer...
Source: Prostaglandins and Other Lipid Mediators - April 14, 2018 Category: Lipidology Source Type: research

Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro
Publication date: March 2018 Source:Prostaglandins & Other Lipid Mediators, Volume 135 Author(s): Sheuli Afroz, Ayano Yagi, Kouki Fujikawa, M. Motiur Rahman, Katsuya Morito, Tatsuya Fukuta, Shiro Watanabe, Emi Kiyokage, Kazunori Toida, Taro Shimizu, Tatsuhiro Ishida, Kentaro Kogure, Akira Tokumura, Tamotsu Tanaka Lysophosphatidic acid (LPA) is a bioactive phospholipid that induces diverse biological responses. Recently, we found that LPA ameliorates NSAIDs-induced gastric ulcer in mice. Here, we quantified LPA in 21 medicinal herbs used for treatment of gastrointestinal (GI) disorders. We found that...
Source: Prostaglandins and Other Lipid Mediators - April 2, 2018 Category: Lipidology Source Type: research