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Role of sphingolipids in the pathogenesis of intrahepatic cholestasis
ConclusionIt is known that sphingolipids serve as modulators of liver regeneration. We assume these substances could be potential markers for detecting early onsets of intrahepatic cholestasis of pregnancy. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 14, 2019 Category: Lipidology Source Type: research

Parasitic load determination by differential expression of 5-Lipoxygenase and PGE2 Synthases in Visceral Leishmaniasis
In this study, we intend to explore linkage between organ specific immune response and eicosanoids. We suggest that eicosanoids (early immune modulators) and their organ specific expressions, possibly tune the outcome of mφ differently at different sites. We have observed that liver showed better containment of parasitic load than spleen, where we have found higher expression of 5-lipoxygenase (5-LO) enzyme along with IL-12 and iNOS. However, in spleen, enzymes of the PGE2 pathway (PGE2 cytosolic and PGE2 microsomal) along with IL-10 were predominantly higher. To further corroborate our findings, in vitro assays were carr...
Source: Prostaglandins and Other Lipid Mediators - November 12, 2019 Category: Lipidology Source Type: research

A journey of celecoxib from pain to cancer
Publication date: Available online 11 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Pratiksha Saxena, Pramod K. Sharma, Priyank PurohitAbstractThe most enthralling and versatile class of drugs called the Non-steroidal anti-inflammatory (NSAIDs) showed its therapeutic utility in inflammation, beginning from the era of classic drug ‘Aspirin’. NSAIDs and their well-established action based on inhibiting the COX-1 and COX-2 enzyme leads to blockage of prostaglandin pathway. They further categorized into first generation (non-selective inhibitor) and second generation (selective COX-2 inhibitors). Se...
Source: Prostaglandins and Other Lipid Mediators - November 12, 2019 Category: Lipidology Source Type: research

Lipid Mediators of Inflammation and Resolution in Individuals with Tuberculosis and Tuberculosis-Diabetes
Publication date: Available online 11 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Rupak Shivakoti, Jesmond Dalli, Dileep Kadam, Sanjay Gaikwad, Madhusudan Barthwal, Romain A. Colas, Francesca Mazzacuva, Rahul Lokhande, Sujata Dharmshale, Renu Bharadwaj, Anju Kagal, Neeta Pradhan, Sona Deshmukh, Sachin Atre, Tushar Sahasrabudhe, Arjun Kakrani, Vandana Kulkarni, Swapnil Raskar, Nishi Suryavanshi, Sandy ChonABSTRACTIndividuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a compr...
Source: Prostaglandins and Other Lipid Mediators - November 12, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: December 2019Source: Prostaglandins & Other Lipid Mediators, Volume 145Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 8, 2019 Category: Lipidology Source Type: research

Dietary omega-3 PUFA improved tubular function after ischemia induced acute kidney injury in mice but did not attenuate impairment of renal function
In conclusion, n3-PUFA food supplementation altered the oxylipin levels significantly but did not protect from renal function deterioration or attenuate ischemia induced renal inflammation. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

Targeting Esterified Oxylipins by LC-MS – Effect of Sample Preparation on Oxylipin Pattern
Publication date: Available online 4 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Annika I. Ostermann, Elisabeth Koch, Katharina M. Rund, Laura Kutzner, Malwina Mainka, Nils Helge SchebbAbstractA major part of oxygenated metabolites of polyunsaturated fatty acids – i.e. eicosanoids and other oxylipins – in biological samples occurs in the esterified form. Yet, their biological role is only poorly understood. For quantification of esterified oxylipins in biological samples current protocols mostly apply alkaline hydrolysis with or without prior lipid extraction to release oxylipins in their free...
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

Lipoxin A4 inhibited the activation of Hepatic Stellate Cells -T6 cells by modulating profibrotic cytokines and NF-κB signaling pathway
ConclusionLXA4 inhibited HSCs activation through down-regulation TGF-β1/PDGF, and repression NF-κB signal pathway. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

A review on mPGES-1 inhibitors: From preclinical studies to clinical applications
Publication date: Available online 4 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Filip Bergqvist, Ralf Morgenstern, Per-Johan JakobssonAbstractProstaglandin E2 (PGE2) is a lipid mediator of inflammation and cancer progression. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases (COX) and the terminal enzyme microsomal prostaglandin E synthase-1 (mPGES-1). Widely used non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity, resulting in decreased PGE2 production and symptomatic relief. However, NSAIDs block the production of many other lipid mediators that have imp...
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

Prostaglandins and Other Lipid Mediators Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
Publication date: Available online 5 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Jogen Atone, K Wagner, Kenji Hashimoto, Bruce HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition...
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

A combination of LCPUFAs regulates the expression of miRNA-146a-5p in a murine asthma model and human alveolar cells
ConclusionOur results demonstrate the modulative capacity of LCPUFAs on dysregulated miRNA expression in asthma. In addition, we pointed out the high regulative potential of LCPUFAs on 5-LO regulation and provided evidence that miR-146a partly controls the regulation of 5-LO. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 4, 2019 Category: Lipidology Source Type: research

Oxysterols as Lipid Mediators: Their Biosynthetic Genes, Enzymes and Metabolites
Publication date: Available online 4 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): William J. Griffiths, Yuqin WangAbstractThere is growing evidence that oxysterols are more than simple metabolites in the pathway from cholesterol to bile acids. Recent data has shown oxysterols to be ligands to nuclear receptors and to G protein-coupled receptors, modulators of N-methyl-D-aspartate receptors and regulators of cholesterol biosynthesis. In this mini-review we will discuss the biosynthetic mechanisms for the formation of different oxysterols and the implication of disruption of these mechanisms in healt...
Source: Prostaglandins and Other Lipid Mediators - November 4, 2019 Category: Lipidology Source Type: research

Prostaglandin E2, a postulated mediator of neurovascular coupling, at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles
Publication date: Available online 2 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Andras Czigler, Luca Toth, Nikolett Szarka, Krisztina Szilágyi, Zoltan Kellermayer, Alexandra Harci, Monika Vecsernyes, Zoltan Ungvari, Alex Szolics, Akos Koller, Andras Buki, Peter TothAbstractThere is considerable controversy regarding the vasoactive action of prostaglandin E2 (PGE2). On the one hand, indirect evidence implicates that astrocytic release of PGE2 contributes to neurovascular coupling responses mediating functional hyperemia in the brain. On the other hand, overproduction of PGE2 was also reported to ...
Source: Prostaglandins and Other Lipid Mediators - November 3, 2019 Category: Lipidology Source Type: research

Interaction between PGI2 and ET-1 pathways in vascular smooth muscle from Group-III pulmonary hypertension patients
Publication date: Available online 28 October 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Gulsev Ozen, Chabha Benyahia, Yasmine Amgoud, Jigisha Patel, Heba M. Abd Elmoneim, Amel Bouhadoun, Sonia Yung, Fangfang Li, Youcef Mahieddine, Adam M. Silverstein, Yves Castier, Aurélie Cazes, Dan Longrois, Lucie H. Clapp, Xavier NorelAbstractPulmonary hypertension (PH) is characterized by an elevation of mean pulmonary artery pressure and it is classified into five groups. Among these groups, PH Group-III is defined as PH due to lung disease or hypoxia. Prostacyclin (PGI2) analogues (iloprost, treprostinil) and endo...
Source: Prostaglandins and Other Lipid Mediators - October 29, 2019 Category: Lipidology Source Type: research

Time-resolved Phosphoproteomic Analysis Elucidates Hepatic 11,12-Epoxyeicosatrienoic Acid Signaling Pathways
Publication date: Available online 24 October 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Marco Rahm, Juliane Merl-Pham, Jerzy Adamski, Stefanie M. HauckAbstractEpoxyeicosatrienoic acids (EETs) are potent lipid mediators with well-established effects in vascular tissues. Recent studies indicated an emerging role of these eicosanoids in metabolic diseases and the EET signaling pathway was shown to be involved in hepatic insulin sensitivity. However, compared to vascular tissues, there is only limited knowledge about the underlying signaling pathways in the liver. Therefore, we employed an LC-MS/MS-based tim...
Source: Prostaglandins and Other Lipid Mediators - October 25, 2019 Category: Lipidology Source Type: research