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Control of myogenic tone and agonist induced contraction of intramural coronary resistance arterioles by cannabinoid type 1 receptors and endocannabinoids
Publication date: Available online 16 October 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Mária Szekeres, György L. Nádasy, Eszter Soltész-Katona, László Hunyady It was tested whether intrinsic CB1R activation modifies myogenic and agonist induced contraction of intramural coronary resistance arteries of the rat. CB1R protein was detected by immuno-histochemistry and by Western blot, its mRNA by qRT-PCR in their wall. Microsurgically prepared cylindrical coronary segments (∼100–150μm) developed myogenic contraction (∼20% of relaxed luminal diameter), from which a substantial rel...
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Opposing roles of PGD2 in GBM
Conclusions Our study demonstrates that prostaglandin D2 possesses a dynamic, concentration-dependent effect in GBM cell activities. The increase of PGD2 production in GBM patients suggests a pro-tumorigenic role of PGD2 in glioma growth and invasion. Therefore, prostaglandin signaling in GBM requires further investigation to identify new targets for more effective therapies. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Relaxant effect of the prostacyclin analogue iloprost on isolated human radial artery: An approach for the reversal of graft spasm
Publication date: Available online 26 October 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Ersoy Engin, F. İlkay Alp Yildirim, Deniz Kalelі Durman, Suat Nail Ömeroğlu, Deniz Göksedef, Önder Teskіn, Ozan Onur Balkanay, Gökhan İpek, B. Sönmez Uydeş Doğan Radial artery graft spasm in the perioperative or postoperative period of coronary bypass surgery necessitates urgent treatment due to risk of graft failure and mortality. Herein, we evaluated the effect of iloprost, a prostacyclin (PGI2) analogue, against the contractions produced by noradrenaline and potassium chloride on iso...
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Intermittent hypoxia alters dose dependent caffeine effects on renal prostanoids and receptors in neonatal rats
Publication date: Available online 26 October 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Kay D. Beharry, Charles L. Cai, Kultida Soontarapornchai, Taimur Ahmad, Gloria B. Valencia, Jacob V. Aranda Caffeine, one of the most commonly prescribed drugs in preterm neonates, is given in standard or suprapharmacologic doses. Although known as a diuretic, its effects in the neonatal kidneys are not well studied. We tested the hypothesis that neonatal intermittent hypoxia (IH) and high caffeine doses (HCD) alter renal regulators of vasomotor tone and water balance. Newborn rats were randomized to ...
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Editorial —Special issue of the 6th European Workshop on Lipid Mediators
Publication date: Available online 4 November 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Dieter Steinhilber, Sönmez Uydeş Doğan, Gökçe Topal, Joan Clària, Xavier Norel, Nils Helge Schebb, Gerard Bannenberg (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: potential role in diabetic nephropathy
Publication date: Available online 15 November 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Yasuhiro Watanabe, Takashi Yamaguchi, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Rena Oka, Haruki Imamura, Yuta Sato, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno 7-Ketocholesterol (7-KCHO) is a highly proinflammatory oxysterol and plays an important role in the pathophysiology of diabetic nephropathy (DN). Lipoxygenases (LOXs) and cyclooxygenases (COXs) are also involved in the development of DN. The aim of this study was to clarify the effect...
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry
Publication date: January 2018 Source:Prostaglandins & Other Lipid Mediators, Volume 134 Author(s): Bruce Pier, Johnathan W. Edmonds, Landon Wilson, Alireza Arabshahi, Ray Moore, G.Wright Bates, Jeevan K. Prasain, Michael A. Miller Prostaglandins are formed by enzymatic and non-enzymatic mechanisms. They have been detected in human ovarian follicular fluid (HFF), a medium rich in growth factors and nutrients important for oocyte growth and fertility. However, the comprehensive identification of HFF prostaglandins has not been addressed. Here we use hybrid triple quadrupole time-of-flight and triple quadru...
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney
Publication date: January 2018 Source:Prostaglandins & Other Lipid Mediators, Volume 134 Author(s): Jing Wang, Min Liu, Xiaoyan Zhang, Guangrui Yang, Lihong Chen Prostaglandin E2 (PGE2) is the most abundant prostanoid synthesized in the kidney and plays an important role in renal function. Physiologically, PGE2 regulates renal hemodynamics, water and sodium metabolism, blood pressure, and so on. As a well-known proinflammatory lipid mediator, PGE2 also substantially mediates renal injury under many pathophysiological conditions. Multiple enzymes are involved in renal PGE2 biosynthesis, including the three ma...
Source: Prostaglandins and Other Lipid Mediators - November 19, 2017 Category: Lipidology Source Type: research

Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia
In conclusion, 20-HETE inhibition in RUPP rats reduces BP and fetal death, and is associated with an increase in EET/20-HETE ratio. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - September 23, 2017 Category: Lipidology Source Type: research

Effects of stimulation technique, anatomical region, and time on human sweat lipid mediator profiles
Publication date: Available online 21 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Karan Agrawal, Justin D. Waller, Theresa L. Pedersen, John W. Newman Few studies compare sampling protocol effect on sweat composition. Here we evaluate the impact of sweat stimulation mode and site of collection on lipid mediator composition. Sweat from healthy males (n =7) was collected weekly for three weeks from the volar forearm following either pilocarpine iontophoresis or exercise, and from the forearm, back and thigh following pilocarpine iontophoresis only. Sweat content of over 150 lipid med...
Source: Prostaglandins and Other Lipid Mediators - September 22, 2017 Category: Lipidology Source Type: research

Human retinal endothelial cells and astrocytes cultured on 3-d scaffolds for ocular drug discovery and development
Publication date: Available online 17 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Kay D. Beharry, Charles L. Cai, Gloria B. Valencia, Douglas Lazzaro, Arwin M. Valencia, Fabrizio Salomone, Jacob V. Aranda Topical ocular ketorolac improves the outcomes of severe retinopathy of prematurity and when administered with systemic caffeine, decreases the severity of oxygen-induced retinopathy. We tested the hypothesis that co-cultures of human retinal endothelial cells (HRECs) and human retinal astrocytes (HRAs) on 3-dimensional (3-D) hydrogel scaffolds is a more representative biomimet...
Source: Prostaglandins and Other Lipid Mediators - September 19, 2017 Category: Lipidology Source Type: research

WEC 2016 Special Issue Editorial
Publication date: Available online 18 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Dipak Panigrahy, Darryl C. Zeldin (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - September 19, 2017 Category: Lipidology Source Type: research

Low-dose DHA-induced astrocyte proliferation can be attenuated by insufficient expression of BLBP in vitro
Publication date: Available online 14 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Haoming Li, Qingqing Yang, Xiao Han, Xuefeng Tan, Jianbing Qin, Guohua Jin Docosahexaenoic acid (DHA) is an n-3 long chain polyunsaturated fatty acid (PUFA) that is involved in a wide range of cellular processes in human cells. Brain lipid binding protein (BLBP) exhibits a high affinity for n-3 PUFAs, especially DHA, but the precise functional contributions of DHA and BLBP in astrocytes are not clear. We analyzed cell viability and the ratio of Ki67 positive cells after manipulating DHA and/or BLBP ...
Source: Prostaglandins and Other Lipid Mediators - September 15, 2017 Category: Lipidology Source Type: research

Differential involvement of L- and T-type Ca2+ channels, store-operated calcium channel (TRPC) and Rho-kinase signaling pathway(s) in PGF2 α-induced contractions in myometrium of non-pregnant and pregnant buffaloes (Bubalus bubalis)
This study unravels the differential involvement of calcium signaling pathway(s) in PGF2α-induced contractions in myometrium of non-pregnant and pregnant buffaloes. Compared to the myometrium of pregnant animals, myometrium of non-pregnant buffaloes was more sensitive to PGF2α–induced contractile effect as manifested by the changes in mean integral tension (MIT) and tonicity. However, phasic contraction was significantly more in myometrium of pregnant animals. The uterotonic effect of PGF2α was dependent on extracellular Ca2+ and its influx through nifedipine-sensitive L-type Ca2+ channels both in non-pregnant and pre...
Source: Prostaglandins and Other Lipid Mediators - September 13, 2017 Category: Lipidology Source Type: research

Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa
Publication date: Available online 2 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): P. Betty Shih, Christophe Morisseau, Thu Le, Blake Woodside, J. Bruce German Anorexia nervosa (AN) is a complex psychiatric disorder with high morbidity and mortality rates. While many individuals make full recoveries, up to a third of patients develop a chronic, treatment-resistant form of the illness that leads to a premature death in 15–20% of those affected. There have been few advances in treatment, both in terms of psychological or pharmacologic treatment over the last 30 years. Food aversion ...
Source: Prostaglandins and Other Lipid Mediators - September 12, 2017 Category: Lipidology Source Type: research