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Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia
In conclusion, metabolism of AA via CYP450 is altered in PE, and increased placental production of 20-HETE may contribute to the pathophysiology of the disease. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid-derived oxidized lipid metabolites modulate the inflammatory response of lipolysaccharide-stimulated macrophages
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): John P. Caron, Jeffrey C. Gandy, Jennifer L. Brown, Lorraine M. SordilloAbstractDocosahexaenoic acid (DHA) supplementation has demonstrated beneficial effects in a number of inflammatory diseases. Increasingly, important contributions to its favorable effects are attributed downstream metabolites called docosanoids. Herein, we investigated the role of DHA-derived oxidized lipid metabolites on inflammatory mediator expression by RAW 264.7 murine macrophages. Specifically, macrophage incorporation of DHA, and the resultant biosynth...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): Shinji Toki, Weisong Zhou, Kasia Goleniewska, Sara Reiss, Daniel E. Dulek, Dawn C. Newcomb, William E. Lawson, R. Stokes PeeblesAbstractEndogenous prostaglandin I2 (PGI2) has inhibitory effects on immune responses against pathogens or allergens; however, the immunomodulatory activity of endogenous PGI2 signaling in endotoxin-induced inflammation is unknown. To test the hypothesis that endogenous PGI2 down-regulates endotoxin-induced lung inflammation, C57BL/6 wild type (WT) and PGI2 receptor (IP) KO mice were challenged intranasa...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Sphingolipid signaling modulates trans-endothelial cell permeability in dengue virus infected HMEC-1 cells
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): M.G. Anupriya, Sneha Singh, Neha Vijay Hulyalkar, Easwaran SreekumarAbstractDengue has emerged as a major mosquito-borne disease in the tropics and subtropics. In severe dengue, enhanced microvascular endothelial permeability leads to plasma leakage. Direct dengue virus (DENV) infection in human microvascular endothelial cells (HMEC-1) can enhance trans-endothelial leakage. Using a microarray-based analysis, we identified modulation of key endothelial cell signaling pathways in DENV-infected HMEC-1 cells. One among them was the s...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway
ConclusionIn conclusion, these results suggest that sustained presence of lipid inflammatory mediator LTD4 could induce human airway epithelial cell proliferation through ERK1/2 phosphorylation, either directly via CysLT1 receptor or by transactivating EGFR.Graphical abstract (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): Stevan Pecic, Amir A. Zeki, Xiaoming Xu, Gina Y. Jin, Shuwei Zhang, Sean Kodani, Marlin Halim, Christophe Morisseau, Bruce D. Hammock, Shi-Xian DengAbstractWe have previously identified and reported several potent piperidine-derived amide inhibitors of the human soluble epoxide hydrolase (sEH) enzyme. The inhibition of this enzyme leads to elevated levels of epoxyeicosatrienoic acids (EETs), which are known to possess anti-inflammatory, vasodilatory, and anti-fibrotic effects. Herein, we report the synthesis of 9 analogs of the l...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats
ConclusionInhibition of the sEH alleviates diabetes-induced decline in learning and memory. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice
The objective of this study was to characterize the time course of 12LO isoform expression and metabolite production in pancreatic islets and AT of C57BLKS/J-db/db obese diabetic mouse in a pre-diabetic state in order to establish a suitable therapeutic window for intervention with selective lipoxygenase inhibitors.Mice have 2 major 12LO isoforms –the leukocyte type (12/15LO) and the platelet type (p12LO) and both are expressed in islets and AT. We found a sharp increase in protein expression of 12/15LO in the pancreatic islets of 10-week old db-/- mice compared to 8- week old counterparts. Immunohistochemistry showed th...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

The prostanoid pathway contains potential prognostic markers for glioblastoma
Publication date: Available online 30 June 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Alexandros Theodoros Panagopoulos, Renata Nascimento Gomes, Fernando Gonçalves Almeida, Felipe da Costa Souza, José Carlos Esteves Veiga, Anna Nicolaou, Alison ColquhounAbstractProstanoids derived from the activity of cyclooxygenases and their respective synthases contribute to both active inflammation and immune response in the tumor microenvironment. Their synthesis, deactivation and role in glioma biology have not yet been fully explored and require further study. Using quantitative real time PCR, gas chromatography...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Drawing a link between the thromboxane A2 pathway and the role of platelets and tumor cells in ovarian cancer
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Karolina Serhan, Allison Gartung, Dipak PanigrahyAbstractOvarian cancer is the most lethal gynecologic malignancy among women. Due to the heterogeneity and complexity of the disease, as well as the insidious onset of symptoms, timely diagnosis remains extremely challenging. Despite recent advances in chemotherapy regimens for ovarian cancer patients, many still suffer from recurrence and ultimately succumb to the disease; thus, there is an urgent need for the identification of novel therapeutic targets. Within this rapidly evolv...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Karan Agrawal, Rémy Bosviel, Brian D. Piccolo, John W. NewmanAbstractSweat contains a variety of lipid mediators, but whether they originate from the plasma filtrate or from the cutaneous sweat glandular tissues themselves is unknown. To explore this knowledge gap, we collected plasma and sweat from healthy men (n = 9) immediately before and 0.5, 2 and 4 h after oral administration of 400 mg ibuprofen. Of the over 100 lipid mediators assayed by liquid chromatography-tandem mass spectrometry, ∼45 were detected in both ...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Fen Xu, Xiaoyan Zhou, Jian Hao, Hua Dai, Jian Zhang, Yuanqiao He, Hua HaoAbstractEpithelial-mesenchymal Transition (EMT) and migration play an important role in tumor progression, and lipoxin (LX), the ‘stop signal’ for inflammation, has been studied in basic research for its anti-inflammatory or inflammatory pro-resolving properties. Here, in the in vitro experiment, we showed that LXA4 could inhibit the EMT and migration in phorbol myristate acetate (PMA) or activated conditioned medium (ACM)-stimulated Hep3B cells by down...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Johan Kolmert, Sergio Piñeiro-Hermida, Mats Hamberg, Joshua A. Gregory, Icíar P. López, Alexander Fauland, Craig E. Wheelock, Sven-Erik Dahlén, José G. Pichel, Mikael AdnerAbstractThe profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation remains unclear. This experimental study quantified metabolite levels of ω3-, ω6- and ω9-derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of repeated house dust mite (HDM) exposure in a murine (C57BL/6) asthma model...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P. Singh, David Bamshad, John A. McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T. Stier, Nader G. AbrahamAbstractBackgroundWe have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on renal and adipose tissue function, in addition to its vasodilatory action; it increases insulin sensitivity and inhibits inflammation. In an examination of the signaling mechanisms by which EET reduces renal and peri-renal fat function, we hyp...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research

Physiological response to central and peripheral injection of prostaglandin D2 in chicks
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): Tetsuya Tachibana, Yasua Nakai, Ryosuke Makino, Md. Sakirul Islam Khan, Mark A. ClineAbstractProstaglandin D2 (PGD2) is associated with a diverse array of functions in mammals including regulation of appetite, body temperature, sleep, and immune responses. Although much is known about the effects of PGD2 in mammals, there is a lack of information about its effects in birds. Therefore, the purpose of the present study was to determine if intracerebroventricular (ICV) and intraperitoneal (IP) injections of PGD2 affect feeding, vol...
Source: Prostaglandins and Other Lipid Mediators - July 5, 2018 Category: Lipidology Source Type: research