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Association between the EPHX2 p.Lys55Arg Polymorphism and Prognosis Following an Acute Coronary Syndrome
Publication date: Available online 7 August 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Akinyemi Oni-Orisan, Sharon Cresci, Philip G. Jones, Katherine N. Theken, John A. Spertus, Craig R. LeeAbstractInhibition of soluble epoxide hydrolase (sEH, EPHX2) elicits potent cardiovascular protective effects in preclinical models of ischemic cardiovascular disease (CVD), and genetic polymorphisms in EPHX2 have been associated with developing ischemic CVD in humans. However, it remains unknown whether EPHX2 variants are associated with prognosis following an ischemic CVD event. We evaluated the association between E...
Source: Prostaglandins and Other Lipid Mediators - August 8, 2018 Category: Lipidology Source Type: research

Ablation of Soluble Epoxide Hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo
In this study, we explore the effects of soluble epoxide hydrolase (sEH) deletion on various aspects of adipocyte-function, including programing for white vs. beige-like fat, and mitochondrial and thermogenic gene-expressions. We further hypothesize that EETs and heme-oxygenase 1 (HO-1) form a synergistic, functional module whose effects on adipocyte and vascular function is greater than the effects of sEH deletion alone. In in vitro studies, we examined the effect of sEH inhibitors on MSC-derived adipocytes. MSC-derived adipocytes exposed to AUDA, an inhibitor of sEH, exhibit an increased number of small and healthy adipo...
Source: Prostaglandins and Other Lipid Mediators - July 22, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: July 2018Source: Prostaglandins & Other Lipid Mediators, Volume 137Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 20, 2018 Category: Lipidology Source Type: research

Neuroprotective Effects of Epoxyeicosatrienoic Acids
This article summarizes the metabolic pathway of eicosatrienoic acid in organisms and highlights its neuroprotective effects on the central nervous system, which include regulating neuronal excitability, increasing cerebral blood flow, inhibiting neuronal apoptosis, reducing neuroinflammation, mitigating brain injury and promoting recovery of neurological function in subjects with nervous system diseases. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 19, 2018 Category: Lipidology Source Type: research

The contribution of TRPV1 channel to 20-HETE—Aggravated ischemic neuronal injury
Publication date: Available online 6 July 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Xiaofan Zhang, Nagat El Demerdash, John R. Falck, Sailu Munnuri, Raymond C. Koehler, Zeng-Jin YangAbstract20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 (CYP) 4A/4F-derived metabolite of arachidonic acid, directly contributes to ischemic neuronal injury. However, little is known about mediators of 20-HETE neurotoxicity after ischemia. Here, we focus on the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) in 20-HETE-induced neurotoxicity. Our results showed that TRPV1 and CYP4A...
Source: Prostaglandins and Other Lipid Mediators - July 12, 2018 Category: Lipidology Source Type: research

Different administration patterns of docosahexaenoic acid in combating cytotoxic manifestations due to arsenic trioxide (acute promyelocytic leukemia drug) induced redox imbalance in hepatocytes
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): S Abhilash, R Siviyasankar, P Binu, P Arathi, R Harikumaran NairAbstractDocosahexaenoic acid (DHA) obtained from fish and plant sources is an essential dietary fatty acid and an important cell membrane structural component. The acute promyelocytic leukemia (APL) drug arsenic trioxide (As2O3), causes hepatotoxicity. We evaluated the protective potential of DHA as pre/combination/post-administration patterns against As2O3 induced toxicity. The therapeutic concentration of As2O3 (10 μM) resulted in cytotoxicity with a significant...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease
Conclusionn-3 FA supplementation in patients with CKD leads to increased neutrophil release of LTB5 and several SPM, as well as a reduction in plasma MPO that may have important implications for limiting chronic inflammation. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression
ConclusionOur data suggest that the increase in EET levels may be part of a protective mechanism in ulcerative colitis. Furthermore, the concentration of EETs could be a key factor for drug therapy for ulcerative colitis. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Arachidonic acid metabolites of CYP4A and CYP4F are altered in women with preeclampsia
In conclusion, metabolism of AA via CYP450 is altered in PE, and increased placental production of 20-HETE may contribute to the pathophysiology of the disease. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid-derived oxidized lipid metabolites modulate the inflammatory response of lipolysaccharide-stimulated macrophages
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): John P. Caron, Jeffrey C. Gandy, Jennifer L. Brown, Lorraine M. SordilloAbstractDocosahexaenoic acid (DHA) supplementation has demonstrated beneficial effects in a number of inflammatory diseases. Increasingly, important contributions to its favorable effects are attributed downstream metabolites called docosanoids. Herein, we investigated the role of DHA-derived oxidized lipid metabolites on inflammatory mediator expression by RAW 264.7 murine macrophages. Specifically, macrophage incorporation of DHA, and the resultant biosynth...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): Shinji Toki, Weisong Zhou, Kasia Goleniewska, Sara Reiss, Daniel E. Dulek, Dawn C. Newcomb, William E. Lawson, R. Stokes PeeblesAbstractEndogenous prostaglandin I2 (PGI2) has inhibitory effects on immune responses against pathogens or allergens; however, the immunomodulatory activity of endogenous PGI2 signaling in endotoxin-induced inflammation is unknown. To test the hypothesis that endogenous PGI2 down-regulates endotoxin-induced lung inflammation, C57BL/6 wild type (WT) and PGI2 receptor (IP) KO mice were challenged intranasa...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Sphingolipid signaling modulates trans-endothelial cell permeability in dengue virus infected HMEC-1 cells
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): M.G. Anupriya, Sneha Singh, Neha Vijay Hulyalkar, Easwaran SreekumarAbstractDengue has emerged as a major mosquito-borne disease in the tropics and subtropics. In severe dengue, enhanced microvascular endothelial permeability leads to plasma leakage. Direct dengue virus (DENV) infection in human microvascular endothelial cells (HMEC-1) can enhance trans-endothelial leakage. Using a microarray-based analysis, we identified modulation of key endothelial cell signaling pathways in DENV-infected HMEC-1 cells. One among them was the s...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway
ConclusionIn conclusion, these results suggest that sustained presence of lipid inflammatory mediator LTD4 could induce human airway epithelial cell proliferation through ERK1/2 phosphorylation, either directly via CysLT1 receptor or by transactivating EGFR.Graphical abstract (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research

Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability
Publication date: May 2018Source: Prostaglandins & Other Lipid Mediators, Volume 136Author(s): Stevan Pecic, Amir A. Zeki, Xiaoming Xu, Gina Y. Jin, Shuwei Zhang, Sean Kodani, Marlin Halim, Christophe Morisseau, Bruce D. Hammock, Shi-Xian DengAbstractWe have previously identified and reported several potent piperidine-derived amide inhibitors of the human soluble epoxide hydrolase (sEH) enzyme. The inhibition of this enzyme leads to elevated levels of epoxyeicosatrienoic acids (EETs), which are known to possess anti-inflammatory, vasodilatory, and anti-fibrotic effects. Herein, we report the synthesis of 9 analogs of the l...
Source: Prostaglandins and Other Lipid Mediators - July 10, 2018 Category: Lipidology Source Type: research