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Relevance of seminal F2-dihomo-IsoPs, F2-IsoPs and F4-NeuroPs in idiopathic infertility and varicocele
Publication date: Available online 6 April 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mariangela Longini, Elena Moretti, Cinzia Signorini, Daria Noto, Francesca Iacoponi, Giulia Collodel (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - April 7, 2020 Category: Lipidology Source Type: research

Mechanisms underlying the protective effect of leukotriene receptor antagonist montelukast against doxorubicin induced testicular injury in rats
Publication date: Available online 12 March 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mervat Z. Mohamed, Nagwa M. Zenhom (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 13, 2020 Category: Lipidology Source Type: research

Sphingosine 1-phosphate signaling in ischemia and reperfusion injury
Publication date: Available online 12 March 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Zohaib Raza, Uzma Saleem, Zainab Naureen (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 12, 2020 Category: Lipidology Source Type: research

Lipocalin-type Prostaglandin D2 Synthase Deletion Induces Dyslipidemia and Non-alcoholic Fatty Liver Disease
Publication date: Available online 4 March 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Sunil Kumar, Ankita Srivastava, Thomas Palaia, Christopher Hall, Jenny Lee, Matthew Stevenson, Chaohui Lisa Zhao, Louis Ragolia (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 6, 2020 Category: Lipidology Source Type: research

Effects of antiemetic doses of dexamethasone on plasma mediators of inflammation resolution and pain after surgery in women
Publication date: Available online 19 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Anne Barden, Michael Phillips, Emilie Mas, Lisa M. Hill, Ian Mowat, P.S. Loh, Tomas Corcoran, Trevor A. Mori (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - February 20, 2020 Category: Lipidology Source Type: research

Editorial—Special issue of the 7th European workshop on lipid mediators
Publication date: June 2020Source: Prostaglandins & Other Lipid Mediators, Volume 148Author(s): Mireille Alhouayek, Gerard Bannenberg, Giulio G. Muccioli, Xavier Norel, Chengcan Yao, Nils Helge Schebb (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - February 20, 2020 Category: Lipidology Source Type: research

Lipoxin A4 reduces house dust mite and TNFα-induced hyperreactivity in the mouse trachea
Publication date: Available online 15 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Willem Abma, Malin Noreby, Craig E. Wheelock, Sven-Erik Dahlén, Mikael Adner, Jesper SäfholmAbstractLipoxin A4 (LXA4) is considered a specialised pro-resolving mediator that decreases inflammation: however, pro-inflammatory effects have been described in the airways. Here, we investigated whether LXA4 could influence airway hyperreactivity induced in mouse trachea by house dust mite extract (HDM) or TNFα. Intranasal instillation of HDM caused a serotonin (5-HT) mediated airway hyperreactivity ex vivo (Emax: 78.1â€...
Source: Prostaglandins and Other Lipid Mediators - February 16, 2020 Category: Lipidology Source Type: research

Synthesis and function of fatty acids and oxylipins, with a focus on Caenorhabditis elegans
Publication date: Available online 4 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): N.Z. Mokoena, O.M. Sebolai, J. Albertyn, C.H. PohlAbstractPolyunsaturated fatty acids (PUFAs) exhibit a diverse range of important biological functions in most biological systems. These PUFAs can be oxygenated via enzymatic or free radical-mediated reactions to form bioactive oxygenated lipid mediators termed oxylipins. Eicosanoids are broad class of oxylipins that are transient and locally synthesized signalling molecules, including prostaglandins, leukotrienes, lipoxins and thromboxanes, which mediate various physio...
Source: Prostaglandins and Other Lipid Mediators - February 5, 2020 Category: Lipidology Source Type: research

20-hydroxyeicosatetraenoic acid alters endothelial cell barrier integrity independent of oxidative stress and cell death
Publication date: Available online 4 February 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Vengai Mavangira, Jennifer Brown, Jeffery C. Gandy, Lorraine M. SordilloAbstractUnregulated inflammation during bovine mastitis is characterized by severe mammary tissue damage with systemic involvement. Vascular dysfunction underlies tissue pathology because of concurrent oxidative stress mediated by several inflammatory mediators. We recently demonstrated increased production of 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450-derived (CYP) oxylipid that correlated with oxidative stress during severe bov...
Source: Prostaglandins and Other Lipid Mediators - February 5, 2020 Category: Lipidology Source Type: research

CYP-Derived Eicosanoids in Inflammatory Diseases
Publication date: Available online 30 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Bahar Tunctan (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - January 30, 2020 Category: Lipidology Source Type: research

Sphingosine kinase 1 is required for myristate-induced TNFα expression in intestinal epithelial cells
Publication date: Available online 29 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Songhwa Choi, Justin M. Snider, Chris P. Cariello, Johana M. Lambert, Andrea K. Anderson, L. Ashley Cowart, Ashley J. SniderAbstractSaturated fatty acids (SFA) have been known to trigger inflammatory signaling in metabolic tissues; however, the effects of specific SFAs in the intestinal epithelium have not been well studied. Several previous studies have implicated disruption in sphingolipid metabolism by oversupply of SFAs could affect the inflammatory process. Also, our previous studies have implicated sphingosine k...
Source: Prostaglandins and Other Lipid Mediators - January 29, 2020 Category: Lipidology Source Type: research

The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2
Publication date: Available online 28 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Shailendra Anoopkumar-Dukie, Tom Conere, Aileen Houston, Liam King, David Christie, Catherine McDermott, Ashley AllshireAbstractIt is widely accepted that the hypoxic nature of solid tumors contribute to their resistance to radiation therapy. There is increasing evidence that cyclooxygenase-2 (COX-2) contributes to increased resistance of tumors to radiation therapy. Several studies demonstrate that combination of COX-2 selective inhibitors with radiation therapy selectively enhances radioresponsiveness of tumor cells...
Source: Prostaglandins and Other Lipid Mediators - January 28, 2020 Category: Lipidology Source Type: research

Special Issue of the 7th European Workshop on Lipid Mediators
Publication date: Available online 17 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Mireille Al Houayek, Gerard Bannenberg, Giulio G. Muccioli, Xavier Norel, Chengcan Yao, Nils Helge Schebb (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - January 19, 2020 Category: Lipidology Source Type: research

Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells
Publication date: Available online 14 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Liqiang Han, Kun Pang, Xiu ling Li, Juan J Loor, Guo yu Yang, Tengyun GaoAbstractThe accumulation of lipid droplets (LDs) in the cytoplasm plays an important role in energy balance, membrane synthesis and cell signal transduction. The aim of this study was to investigate the profile of phospholipids after SCAP-induced LD formation in bovine mammary epithelial cells (BMECs). A shRNA-SCAP vector and a SCAP/SREBP vector were used to knock down and overexpress the SCAP gene in BMECs prior to evaluating the effects on LDs ...
Source: Prostaglandins and Other Lipid Mediators - January 15, 2020 Category: Lipidology Source Type: research

An overview of lipoxygenase inhibitors with approach of in vivo studies
Publication date: Available online 14 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Ala Orafaie, Mina Mousavian, Hossein Orafai, Hamid SadeghianAbstractLipoxygenases (LOXs) are enzymes which found in organisms that catalyze the peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of the mentioned enzymes and their metabolites in formation of sensitivities, inflammations, many of cancers (prostate, breast, etc), obesity, diabetes and atherosclerosis had been demonstrated. This review aimed to focus on research findings introducing proved LOXs (5/12/15-LOX) inhibi...
Source: Prostaglandins and Other Lipid Mediators - January 15, 2020 Category: Lipidology Source Type: research