Prostaglandins and Other Lipid Mediators 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells
Publication date: Available online 9 April 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Janis Szeremeta, Jessica Karlsson, Mireille Alhouayek, Christopher J. FowlerAbstractRelatively little is known about the endocannabinoid system in human neuroblastoma cell lines. In the present study, we have investigated the expression of the genes coding for the enzymes involved in the synthesis and catabolism of endocannabinoids in the SH-SY5Y cell line. The expression of MGLL, the gene coding for 2-arachidonoylglycerol hydrolytic enzyme monoacylglycerol lipase (MAGL), was found to be 85 and 340 fold lower than the ex...
Source: Prostaglandins and Other Lipid Mediators - April 10, 2019 Category: Lipidology Source Type: research
Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
Publication date: Available online 6 April 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar, Ruchika Kaul-GhanekarAbstractCervical cancer is the second leading cause of cancer death in women in India. Previously, we have reported that alpha linolenic acid (ALA), induced apoptosis in cervical cancer cell lines and reduced expression of E6 and E7 oncoproteins with simultaneous decrease in Cox2/VEGF/MAP kinase proteins. Here, we investigated the tumor retardation potential of flax oil (FO), rich in ALA, in mouse papilloma model. Fla...
Source: Prostaglandins and Other Lipid Mediators - April 7, 2019 Category: Lipidology Source Type: research
Regulation of nicotinic acetylcholine receptor α3 subtype in adipose tissue dysfunction
Publication date: Available online 3 April 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Xiaoqing Bai, Haibing Ju, Li Gao, Yong Xiong, Rong Dai, Xiangzhong Huang, Cui YangABSTRACTNicotinic acetylcholine receptor α3 subtype (α3-nAChR) plays a pivotal role in regulating inflammatory responses. Inflammation leads to the adipose tissue dysfunction and further increases the risk of metabolic and cardiovascular diseases. Therefore, we hypothesize that α3-nAChR could regulate the disorder of adipose functions. Adipocytokines and inflammatory cytokines were evaluated in apolipoprotein E knockout (ApoE-/-) mice af...
Source: Prostaglandins and Other Lipid Mediators - April 4, 2019 Category: Lipidology Source Type: research
Beyond leukotriene formation—The noncanonical functions of 5-lipoxygenase
Publication date: June 2019Source: Prostaglandins & Other Lipid Mediators, Volume 142Author(s): Ann-Kathrin Häfner, Astrid S. Kahnt, Dieter SteinhilberAbstract5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the innate immune system. 5-LO can shuttle between the cytosol and the nucleus. Upon cell activation the protein translocates from soluble cellular compartments to the nuclear membrane. Besides FLAP which is required for cellular leukotriene and SPM formation, 5-LO interacts with other pro...
Source: Prostaglandins and Other Lipid Mediators - April 4, 2019 Category: Lipidology Source Type: research
Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: suppression of SAPK/JNK and p38 MAP kinase
Publication date: Available online 1 April 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Woo Kim, Haruhiko Tokuda, Tetsu Kawabata, Kazuhiko Fujita, Go Sakai, Daiki Nakashima, Junko Tachi, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Takanobu Otsuka, Hiroki Iida, Osamu KozawaAbstractHeat shock protein (HSP) 90 that is ubiquitously expressed in various tissues, is a major molecular chaperone. We have previously demonstrated that prostaglandin D2 (PGD2), a bone remodeling factor, elicits the expression of HSP27, a small HSP, through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) ...
Source: Prostaglandins and Other Lipid Mediators - April 2, 2019 Category: Lipidology Source Type: research
Beyond leukotriene formation – the noncanonical functions of 5-lipoxygenase
Publication date: Available online 28 March 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Ann-Kathrin Häfner, Astrid S. Kahnt, Dieter SteinhilberAbstract5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the innate immune system. 5-LO can shuttle between the cytosol and the nucleus. Upon cell activation the protein translocates from soluble cellular compartments to the nuclear membrane. Besides FLAP which is required for cellular leukotriene and SPM formation, 5-LO interacts with ...
Source: Prostaglandins and Other Lipid Mediators - March 29, 2019 Category: Lipidology Source Type: research
Neutral sphingomyelinase increases and delocalizes in the absence of Toll-Like Receptor 4: a new insight for MPTP Neurotoxicity
In this study, using WT and TLR4-deficient mice, treated or not with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we aimed to investigate the relation between TLR4 and neutral sphingomyelinase (nSMase) in the midbrain. We found that the lack of TLR4 caused increase in nSMase protein expression and enzyme activity in the midbrain, as well as a marked delocalization from the cell membranes. This provoked a decrease in sphingomyelin (SM) species and an increase in ceramide levels. We found that exposure of TLR4-deficient mice to MPTP reduces unsaturated SM species by increasing saturated/unsaturated SM ratio. Saturate...
Source: Prostaglandins and Other Lipid Mediators - March 28, 2019 Category: Lipidology Source Type: research
Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract
The objective of the present study was to determine the influence of dietary supplementation with pomegranate seed oil (PSO) and/or an aqueous extract of dried bitter melon fruits (BME) on breast cancer risk and fatty acid profile in serum of female rats with chemical carcinogen-inflicted mammary tumours. Sprague-Dawley rats (n = 96) were fed control diet or experimental diets supplemented with 0.15 ml PSO/day, BME or jointly PSO and BME. After 21 weeks mammary tumours were subjected to histopathological examination and in serum fatty acids, 8-isoprostaglandin F2α content and indices of desaturases activity were ana...
Source: Prostaglandins and Other Lipid Mediators - March 28, 2019 Category: Lipidology Source Type: research
Editorial Board
Publication date: April 2019Source: Prostaglandins & Other Lipid Mediators, Volume 141Author(s): (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - March 12, 2019 Category: Lipidology Source Type: research
Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants
Publication date: Available online 8 March 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Ahmed E.M. Elhassanny, Daniel A. Ladin, Eman Soliman, Hussam Albassam, Andrew Morris, Robert Kobet, Kathleen Thayne, Colin Burns, Allison S. Danell, Rukiyah Van DrossAbstractThe combined incidence of melanoma and non-melanoma skin cancer (NMSC) is greater than the incidence of all other malignancies in the US. Previously, we demonstrated that the endocannabinoid, arachidonoyl-ethanolamide (AEA), was a potent inducer of apoptosis in NMSC. The metabolism of AEA to the prostaglandin, PGD2-EA, was a prerequisite for AEA cyto...
Source: Prostaglandins and Other Lipid Mediators - March 10, 2019 Category: Lipidology Source Type: research
Omega-3 Fatty Acids and Docosahexaenoic Acid Oxymetabolites Modulate the Inflammatory Response of Equine Recombinant Interleukin1β-stimulated Equine Synoviocytes
Publication date: Available online 2 March 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): John P. Caron, Jeffrey C. Gandy, Jennifer L. Brown, Lorraine M. SordilloAbstractOmega-3 fatty acid (n-3 PUFA) supplementation may have beneficial effects in certain chronic diseases, potentially including osteoarthritis. Favorable effects are attributed, in part, to downstream pro-resolving oxylipid metabolites. We investigated the role of n-3 PUFA and docosahexaenoic acid (DHA)-derived oxylipids (docosanoids) on equine synoviocyte metabolism. We hypothesized that n-3 PUFA and selected docosanoids would modulate inflamma...
Source: Prostaglandins and Other Lipid Mediators - March 4, 2019 Category: Lipidology Source Type: research
Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue
Publication date: Available online 19 February 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Nicholas U. Schwartz, Izolda Mileva, Mikhail Gurevich, Justin Snider, Yusuf A. Hannun, Lina M. ObeidAbstractAccumulation of deoxysphingolipids (deoxySLs) has been implicated in many neural diseases, although mechanisms remain unclear. A major obstacle limiting understanding of deoxySLs has been the lack of a method easily defining measurement of deoxydihydroceramide (deoxydhCer) and deoxyceramide (deoxyCer) in neural tissues. Furthermore, it is poorly understood if deoxySLs accumulate in the nervous system with aging...
Source: Prostaglandins and Other Lipid Mediators - February 19, 2019 Category: Lipidology Source Type: research
A strategy for validating concentrations of oxylipin standards for external calibration
Publication date: Available online 12 February 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Nicole M. Hartung, Malwina Mainka, Nadja Kampschulte, Annika I. Ostermann, Nils Helge SchebbAbstractQuantitative analysis of oxylipins by means of chromatography/mass spectrometry is based on (external) calibration with standard compounds. Therefore, the quality of analytical standards is of fundamental importance for accurate results. Recently launched certified standards with an assured concentration within a narrow range are useful tools for this purpose. However, such standards are only available for a few compou...
Source: Prostaglandins and Other Lipid Mediators - February 13, 2019 Category: Lipidology Source Type: research
Metabolic studies of synaptamide in an immortalized dopaminergic cell line
ConclusionsIn undifferentiated cells, synaptamide uptake and metabolism is driven by its enzymatic hydrolysis (fatty acid amide hydrolase; FAAH), but in differentiating cells, the process seems to be FAAH independent. We conclude that differentiated and undifferentiated N27 cells utilize synaptamide via different mechanisms. This observation could be extrapolated to how different mechanisms may be in place for synaptamide uptake and metabolism in developing and adult dopaminergic cells. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - February 12, 2019 Category: Lipidology Source Type: research
Effects of Nonsteroidal Anti-Inflammatory Drugs on the Expression of Arachidonic Acid-Metabolizing Cyp450 Genes in Mouse Hearts, Kidneys and Livers
This study concluded that NSAIDs altered the expression of ARA-metabolizing cyp450 genes and induced histological alterations that may influence the function of the vital organs. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - February 12, 2019 Category: Lipidology Source Type: research
