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Reduced Coronary Reactive Hyperemia in Mice was Reversed by the Soluble Epoxide Hydrolase Inhibitor (t-AUCB): Role of Adenosine A2A Receptor and Plasma Oxylipins
Publication date: Available online 7 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Ahmad Hanif, Matthew L. Edin, Darryl C. Zeldin, Christophe Morisseau, John R. Falck, Catherine Ledent, Stephen L. Tilley, Mohammed A. Nayeem Coronary reactive hyperemia (CRH) protects the heart against ischemia. Adenosine A2AAR–deficient (A2AAR−/−) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs). sEH–inhibition enhances CRH, increases EET...
Source: Prostaglandins and Other Lipid Mediators - September 8, 2017 Category: Lipidology Source Type: research

☆Prepared for: ​​6th European Workshop on Lipid Mediators Special Issue (SI: 6EWLM) Prostaglandins and Other Lipid Mediators.
Publication date: Available online 2 September 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): P. Betty Shih, Christophe Morisseau, Thu Le, Blake Woodside, J. Bruce German Anorexia nervosa (AN) is a complex psychiatric disorder with high morbidity and mortality rates. While many individuals make full recoveries, up to a third of patients develop a chronic, treatment-resistant form of the illness that leads to a premature death in 15-20% of those affected. There have been few advances in treatment, both in terms of psychological or pharmacologic treatment over the last 30 years. Food aversion is...
Source: Prostaglandins and Other Lipid Mediators - September 3, 2017 Category: Lipidology Source Type: research

Omega-3 polyunsaturated fatty acids reduce vascular tone and inflammation in human saphenous vein
In conclusion, our results suggest that EPA and DHA pretreatment may be beneficial to counteract graft vasospasm and vascular inflammation in SV which are important factors in graft failure development. Therefore, dietary intake of EPA and DHA may have potential clinical applications in improving coronary bypass graft patency. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - August 31, 2017 Category: Lipidology Source Type: research

Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors
Publication date: Available online 25 August 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Bora Inceoglu, Ahmed Bettaieb, Fawaz G. Haj, Aldrin V. Gomes, Bruce D. Hammock The arachidonic acid cascade is arguably the most widely known biologic regulatory pathway. Decades after the seminal discoveries involving its cyclooxygenase and lipoxygenase branches, studies of this cascade remain an active area of research. The third and less widely known branch, the cytochrome P450 pathway leads to highly active oxygenated lipid mediators, epoxy fatty acids (EpFAs) and hydroxyeicosatetraenoic acids (HETE...
Source: Prostaglandins and Other Lipid Mediators - August 26, 2017 Category: Lipidology Source Type: research

A novel mechanism of ascorbate direct modulation of soluble epoxide hydrolase
Publication date: Available online 18 August 2017 Source:Prostaglandins & Other Lipid Mediators Author(s): Bin Zhang, Sharath Kandhi, Yang-Ming Yang, Yicong Le, Wensheng Deng, Jun Qin, Houli Jiang, Ghezal Froogh, Dong Sun, An Huang To test the hypothesis that VitC downregulates soluble epoxide hydrolase (sEH, responsible for converting EETs to DHETs) to stabilize tissue EETs, the heart, lung, liver, kidney, and mesenteric arteries isolated from normal rats were incubated with VitC (1000μM) for 72hours, and tissue sEH expression, along with EET and DHET profiles were assessed. VitC caused significant re...
Source: Prostaglandins and Other Lipid Mediators - August 19, 2017 Category: Lipidology Source Type: research