Opposing roles of PGD2 in GBM
Conclusions Our study demonstrates that prostaglandin D2 possesses a dynamic, concentration-dependent effect in GBM cell activities. The increase of PGD2 production in GBM patients suggests a pro-tumorigenic role of PGD2 in glioma growth and invasion. Therefore, prostaglandin signaling in GBM requires further investigation to identify new targets for more effective therapies.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
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