The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects

This study demonstrated that S1P significantly promotes angiogenesis, inflammation, and barrier integrity, which was attenuated by inhibition of S1P2 or S1P3, suggesting that regulation of S1P2 and S1P3 is a novel therapeutic target for CNV.Graphical abstract

Source: Prostaglandins and Other Lipid Mediators - August 13, 2019 Category: Lipidology Source Type: research