Invited speakers presentations
Publication date: Available online 10 March 2020Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 11, 2020 Category: Toxicology Source Type: research
Poster presentations
Publication date: Available online 10 March 2020Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 11, 2020 Category: Toxicology Source Type: research
Oral presentations
Publication date: Available online 10 March 2020Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 11, 2020 Category: Toxicology Source Type: research
Editorial Board
Publication date: March–April 2020Source: Neurotoxicology and Teratology, Volume 78Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 5, 2020 Category: Toxicology Source Type: research
Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice
Publication date: Available online 27 February 2020Source: Neurotoxicology and TeratologyAuthor(s): Thomas W. Jackson, Gabriel A. Bendfeldt, Kelby A. Beam, Kylie D. Rock, Scott M. Belcher (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - February 28, 2020 Category: Toxicology Source Type: research
Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report
Publication date: Available online 14 February 2020Source: Neurotoxicology and TeratologyAuthor(s): Laura Carlson, Deborah A. Cory-Slechta, Frances A. Champagne, Laura Dishaw, Elaine Faustman, William Mundy, Deborah Segal, Christina Sobin, Carol Starkey, Michele Taylor, Susan L. Makris, Andrew KraftAbstractA key challenge in systematically incorporating mechanistic data into human health assessments is that, compared to studies of apical health endpoints, these data are both more abundant (mechanistic studies routinely outnumber other studies by several orders of magnitude) and more heterogeneous (e.g. different species, t...
Source: Neurotoxicology and Teratology - February 14, 2020 Category: Toxicology Source Type: research
Editorial Board
Publication date: January–February 2020Source: Neurotoxicology and Teratology, Volume 77Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - January 25, 2020 Category: Toxicology Source Type: research
Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor α-dependent manner in perinatal brain
Publication date: Available online 9 January 2020Source: Neurotoxicology and TeratologyAuthor(s): Allyssa Fahrenkopf, Christine K. WagnerAbstractBisphenol A (BPA) is a xenoestrogen that is prevalent in the environment of industrialized nations due its use in the production of many plastic household items. Virtually all adults in the U.S. have detectable levels of BPA in urine and it can be measured in fetal serum and in breastmilk, making developmental exposure a particular concern. The present study utilizes a progesterone receptor (PR) expression bioassay to assess the estrogen receptor α (ERα)-dependent effects of BPA...
Source: Neurotoxicology and Teratology - January 11, 2020 Category: Toxicology Source Type: research
Inhibition of the electron transport chain in propofol induced neurotoxicity in zebrafish embryos
Publication date: Available online 7 January 2020Source: Neurotoxicology and TeratologyAuthor(s): Lin He, Xuan Wang, Shan ZhengAbstractFetal and neonatal exposure to propofol can lead to neuronal death and long-term neurobehavioral deficiencies in both rodents and nonhuman primates. Zebrafish embryo, which is fertilized ex-utero, has provided us a new model species to study the effects of general anesthetics on developing brain. Inhibited electron transport chain leads to mitochondrial dysfunction and insufficient energy production. The aim of this study was to dissect the role of electron transport chain in propofol-induc...
Source: Neurotoxicology and Teratology - January 8, 2020 Category: Toxicology Source Type: research
Sex differences in the association between exposure to indoor particulate matter and cognitive control among children (age 6–14 years) living near coal-fired power plants
Publication date: Available online 7 January 2020Source: Neurotoxicology and TeratologyAuthor(s): Clara G. Sears, Lonnie Sears, Kristina M. ZieroldAbstractCoal fly ash consists of inhalable particulate matter with varying concentrations of neurotoxic metals. Children living near coal-fired power plants with coal fly ash storage facilities may be exposed to coal fly ash when it escapes as fugitive dust emissions into surrounding communities. Previous research on outdoor particulate matter air pollution of similar aerodynamic diameter (PM10) suggests exposure may be associated with impaired cognitive control. The purpose of ...
Source: Neurotoxicology and Teratology - January 8, 2020 Category: Toxicology Source Type: research
Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish
Publication date: Available online 3 January 2020Source: Neurotoxicology and TeratologyAuthor(s): Andrew B. Hawkey, Lilah Glazer, Cassandra Dean, Corinne N. Wells, Kathryn-Ann Odamah, Theodore A. Slotkin, Frederic J. Seidler, Edward D. LevinAbstractFarmers are often chronically exposed to insecticides, which may present health risks including increased risk of neurobehavioral impairment during adulthood and across aging. Experimental animal studies complement epidemiological studies to help determine the cause-and-effect relationship between chronic adult insecticide exposure and behavioral dysfunction. With the zebrafish ...
Source: Neurotoxicology and Teratology - January 5, 2020 Category: Toxicology Source Type: research
Effects of in utero exposure to lanthanum on neurological behavior in rat offspring
Publication date: Available online 28 December 2019Source: Neurotoxicology and TeratologyAuthor(s): Xiao Xiao, Ling Yong, Dandan Liu, Hui Yang, Chunlai Liang, Xudong Jia, Zhaoping Liu, Yan SongAbstractThe increasing use of rare-earth elements in various fields has raised concern from public heath perspective regarding their accumulation in human body. Long-term exposure to lanthanum, one of the frequently used rare-earth elements in biomedicine and agriculture, has been previously shown to exert neurotoxicity during development in rats; however, the effects of short-term exposure to lanthanum during gestation on neurobehav...
Source: Neurotoxicology and Teratology - December 28, 2019 Category: Toxicology Source Type: research
Statistical modeling with litter as a random effect in mixed models to manage “intralitter likeness”
Publication date: Available online 19 December 2019Source: Neurotoxicology and TeratologyAuthor(s): Mari S. Golub, Christina A. SobinAbstract“Intralitter likeness,” the possibility that the shared genetic and/or maternal environment in multiparous species causes strong similarity for outcome variables in littermates, violates a core statistical assumption, that of observation independence, when littermate outcomes are analyzed. Intralitter likeness has been of major concern to investigators for several decades. Despite consensus and guidance, many research reports in the rodent literature continue to ignore intralitter...
Source: Neurotoxicology and Teratology - December 20, 2019 Category: Toxicology Source Type: research
Magnetic resonance imaging and micro-computed tomography reveal brain morphological abnormalities in a mouse model of early moderate prenatal ethanol exposure
ConclusionOur results show that early moderate PEE can cause alterations in the brain that are detectable during development and adulthood. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - December 14, 2019 Category: Toxicology Source Type: research
When siblings matter: Commentary on Golub and Sobin's ‘Statistical modeling of litter as a random effect in mixed models to manage “intralitter likeness”’
Publication date: Available online 11 December 2019Source: Neurotoxicology and TeratologyAuthor(s): Lori L. DriscollAbstractResponsible data practices include acknowledging and properly dealing with data structures in which the assumption of independence of observations is violated. Golub and Sobin uncover a common statistical faux pas in neurodevelopmental research – inconsistent and inadequate handling of the clustered variability associated with the use of multiple littermates – and propose a simple mixed model solution in which litter is included as a random factor. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - December 11, 2019 Category: Toxicology Source Type: research
