Motor deficits, impaired response inhibition, and blunted response to methylphenidate following neonatal exposure to decabromodiphenyl ether
Publication date: Available online 29 July 2017 Source:Neurotoxicology and Teratology Author(s): Vincent P. Markowski, Patrick Miller-Rhodes, Randy Cheung, Calla Goeke, Vincent Pecoraro, Gideon Cohen, Deena J. Small Decabromodiphenyl ether (decaBDE) is an applied brominated flame retardant that is widely-used in electronic equipment. After decades of use, decaBDE and other members of its polybrominated diphenyl ether class have become globally-distributed environmental contaminants that can be measured in the atmosphere, water bodies, wildlife, food staples and human breastmilk. Although it has been banned in Euro...
Source: Neurotoxicology and Teratology - July 29, 2017 Category: Toxicology Source Type: research
Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies: Proceedings of workshops presented at Society of Toxicology and joint Teratology Society and Neurobehavioral Teratology Society meetings
Publication date: Available online 27 July 2017 Source:Neurotoxicology and Teratology Author(s): Abby A. Li, Larry P. Sheets, Kathleen Raffaele, Virginia Moser, Angela Hofstra, Alan Hoberman, Susan L. Makris, Robert Garman, Brad Bolon, Wolfgang Kaufmann, Roland Auer, Edmund Lau, Thomas Vidmar, Wayne J. Bowers The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, a...
Source: Neurotoxicology and Teratology - July 28, 2017 Category: Toxicology Source Type: research
Impacts of maternal diet and exercise on offspring behavior and body weights
In this study, Long-Evans female rats were provided a high fat (60%; HFD) or control diet (CD) 44days before mating and throughout gestation and lactation. Running wheels were available to half of each diet group during the gestational period only, resulting in four conditions: CD diet with (CDRW) or without (sedentary; CDSED) exercise, and HFD with (HFRW) or without (HFSED) exercise. Only male offspring (one per litter) were available for this study: they were put on control diet two weeks after weaning and examined using behavioral evaluations up to four months of age. Before weaning, offspring of CDRW dams weighed less ...
Source: Neurotoxicology and Teratology - July 28, 2017 Category: Toxicology Source Type: research
Differential expression of glutamate transporters in cerebral cortex of paraoxon-treated rats
Publication date: Available online 8 June 2017 Source:Neurotoxicology and Teratology Author(s): Zohreh Zare, Mohsen Tehrani, Alireza Rafiei, Reza Valadan, Moslem Mohammadi Glutamatergic system is involved in pathological effects of organophosphorus (OP) compounds. We aimed to determine in vivo effects of paraoxon, the bioactive metabolite of parathion, on the expression of glutamate transporters as well as Bax and Bcl2 in rat cerebral cortex. Male Wistar rats received an intraperitoneal (i.p.) injection of one of three doses of paraoxon (0.3, 0.7, or 1mg/kg) or corn oil as vehicle (1ml/kg). After 4 or 18h, cerebral ...
Source: Neurotoxicology and Teratology - June 9, 2017 Category: Toxicology Source Type: research
Cognitive impairment in agricultural workers and nearby residents exposed to pesticides in the Coquimbo Region of Chile
In conclusion, both direct and indirect chronic exposure to pesticides affects cognitive functioning in adults and, consequently, actions should be taken to protect the health of not only agricultural workers, but also of residents in agricultural areas. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - June 2, 2017 Category: Toxicology Source Type: research
