S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice
Conclusions Early postnatal VPA administration induces ASD like behavior that is more severe in males, while the redox status changes are more severe in females; SAM corrects both. VPA-induced ASD seems to result from epigenetic changes, while the redox status changes may be secondary. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Prenatal substance exposure and offspring development: Does DNA methylation play a role?
Publication date: Available online 16 February 2018 Source:Neurotoxicology and Teratology Author(s): Valerie S. Knopik, Kristine Marceau, L. Cinnamon Bidwell, Emily Rolan The period of in utero development is one of the most critical windows during which adverse conditions and exposures may influence the growth and development of the fetus as well as its future postnatal health and behavior. Maternal substance use during pregnancy remains a relatively common but nonetheless hazardous in utero exposure. For example, previous epidemiological studies have associated prenatal substance exposure with reduced birth weight,...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: Genetic and epigenetic factors
Publication date: Available online 21 February 2018 Source:Neurotoxicology and Teratology Author(s): Hannah E. Lapp, Sarah Ahmed, Celia L. Moore, Richard G. Hunter Histories of early life stress (ELS) or social discrimination can reach levels of severity characterized as toxic to mental and physical health. Such toxic social stress during development has been linked to altered acute hypothalamic-pituitary-adrenal (HPA) response to social stress in adulthood. However, there are important individual differences in the size and direction of these effects. We explored developmental, genetic, epigenetic, and contextual so...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Protective role of alpha-lipoic acid in impairments of social and stereotyped behaviors induced by early postnatal administration of thimerosal in male rat
Conclusions the results of this preclinical study, consistent with previous studies on mice and rats, reveals that neonatal dose-dependent exposure to Thimerosal mimicking the childhood vaccine schedule can induce abnormal social interactions and stereotyped behaviors similar to those observed in neurodevelopmental disorders such as autism, and, for the first time, revealed that these abnormalities may be ameliorated by ALA. This indicates that ALA may protect against mercurial-induced abnormal behaviors. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Exposure to mephedrone during gestation increases the risk of stillbirth and induces hippocampal neurotoxicity in mice offspring
In conclusion, the present study has shown that regular and repeated exposure to mephedrone during the gestational period increases the risk of low birth weight and stillbirth. Also, repeated use of mephedrone impairs learning and memory processes through hippocampal damage. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation
Publication date: March–April 2018 Source:Neurotoxicology and Teratology, Volume 66 Author(s): Payel Kundu, Steven L. Neese, Suren Bandara, Supida Monaikul, William G. Helferich, Daniel R. Doerge, Ikhlas A. Khan, Susan L. Schantz Age-related declines in cognitive function can impair working memory, reduce speed of processing, and alter attentional resources. In particular, menopausal women may show an acceleration in the rate of cognitive decline as well as an increased vulnerability to brain diseases as estrogens may play a neuroprotective and neurotrophic role in the brain. To treat menopausal symptoms, many ...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Functional MRI in prenatally opioid-exposed children during a working memory-selective attention task
Conclusion Our findings suggest that prenatal opioids affect later brain function, visible through changes in BOLD activation patterns. However, results should be considered preliminary until replicated in larger samples better suited to control for potential confounding factors. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation via regulation of Bax/Bcl-2 ratio
Publication date: March–April 2018 Source:Neurotoxicology and Teratology, Volume 66 Author(s): Sumathi Thangarajan, Aishwarya Vedagiri, Shanmathy Somasundaram, Rathika Sakthimanogaran, Mahalakshmi Murugesan Lead (Pb) intoxication is a prevalent type of environmental toxicity as well as minimal amount of lead exposure is liable for neurobehavioral or perhaps intelligence defects. The present study was undertaken to investigate the beneficial effects of morin in protecting the lead acetate (PbAc)-induced oxidative stress in rat brain. PbAc intoxication resulted in motor deficit, memory impairment and oxidative stres...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Comparative neurotoxicity study of mercury-based inorganic compounds including Ayurvedic medicines Rasasindura and Kajjali in zebrafish model
Publication date: March–April 2018 Source:Neurotoxicology and Teratology, Volume 66 Author(s): Snehasis Biswas, Naay Balodia, Jayesh Bellare Zebrafish behavioral model is a powerful tool for neuroscience research. Behavioral changes in the zebrafish are studied by administering drugs. With the aid of automated and open-source MATLAB program, high-accuracy tracking of zebrafish can be achieved, and the important behavioral parameters can be calculated. Although mercury is accepted as a potent neurotoxin, used as a key element for preparing certain Ayurvedic medicines. In this work, mercury-based inorganic compounds, ...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae
Publication date: March–April 2018 Source:Neurotoxicology and Teratology, Volume 66 Author(s): C.S. Martinez, D.A. Feas, M. Siri, D.E. Igartúa, N.S. Chiaramoni, S. del V. Alonso, M.J. Prieto Epilepsy is a neurological disorder treated with antiepileptic drugs (AEDs). Since AEDs are administered in women in childbearing age, it is critical to study if drugs are capable of inducing developmental toxicity. Along the bibliography available, there is no research comparing teratogenicity and anticonvulsant effect within the same study. In the present study, we evaluated the teratogenic and anticonvulsant effects of s...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Developmental and behavioral alterations in zebrafish embryonically exposed to valproic acid (VPA): An aquatic model for autism
Publication date: March–April 2018 Source:Neurotoxicology and Teratology, Volume 66 Author(s): Jiangfei Chen, Lei Lei, Linjie Tian, Fei Hou, Courtney Roper, Xiaoqing Ge, Yuxin Zhao, Yuanhong Chen, Qiaoxiang Dong, Robert L. Tanguay, Changjiang Huang Autism spectrum disorder (ASD) has complex neurodevelopmental impairments and origins that are linked to both genetic and environmental factors. Hence, there is an urgency to establish animal models with ASD-like characteristics to understand the underlying mechanisms of ASD. Prenatal exposure to valproic acid (VPA) produced ASD-like symptoms in humans, rats, and ...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Sound shock response in larval zebrafish: A convenient and high-throughput assessment of auditory function
In this study, changes in the activity of zebrafish larvae (10 days post fertilization (dpf)) due to exposure to a sudden easily-generated broad-band noise were automatically and objectively recorded and analyzed without building sophisticated equipments. A significant increase in activity was induced by the noise stimulation and the alterations were impaired by gentamicin. In addition, a clear dose-response trend was observed between gentamicin exposure and the impaired activity, and a similar phenomenon was observed between gentamicin exposure and damage to hair cells. Our results suggested that alterations in the acti...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research
Development and behavior alterations in zebrafish embryonically exposed to valproic acid (VPA): Animal model of autism
Publication date: Available online 5 January 2018 Source:Neurotoxicology and Teratology Author(s): Jiangfei Chen, Linjie Tian, Lei Lei, Fei Hou, Courtney Roper, Xiaoqing Ge, Yuxin Zhao, Robert L. Tanguay, Changjiang Huang Autism spectrum disorder (ASD) has complex neurodevelopmental impairments and origins that are linked to both genetic and environmental factors. Hence, there is an urgency to establish animal models with ASD-like characteristics to understand the underlying mechanisms of ASD. Prenatal exposure to valproic acid (VPA) has been shown to cause ASD-like symptoms in humans, rats, and recently zebrafi...
Source: Neurotoxicology and Teratology - January 5, 2018 Category: Toxicology Source Type: research
The impact of prenatal insults on the human placental epigenome: A systematic review
Publication date: Available online 4 January 2018 Source:Neurotoxicology and Teratology Author(s): Helena Palma-Gudiel, Flors Cirera, Fátima Crispi, Elisenda Eixarch, Lourdes Fañanás The placenta is the first human organ to reach full development during pregnancy. It serves as a barrier but also as an interchange surface. Epigenetic changes observed in placental tissue may reflect intrauterine insults while also pointing to physiological pathways altered under exposure to such environmental threats. By means of a systematic search of the literature, 39 papers assessing human placental epigenetic signatures in ass...
Source: Neurotoxicology and Teratology - January 4, 2018 Category: Toxicology Source Type: research
Corrigendum to “Neonatal inhibition of Na+-K+-2Cl−-cotransporter prevents ketamine induced spatial learning and memory impairments” [Neurotoxicol. Teratol. 60 (2017) 82–86]
Publication date: Available online 2 January 2018 Source:Neurotoxicology and Teratology Author(s): Ryan A. Stevens, Brandon D. Butler, Saurabh S. Kokane, Andrew W. Womack, Qing Lin (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - January 2, 2018 Category: Toxicology Source Type: research
