S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice

Conclusions Early postnatal VPA administration induces ASD like behavior that is more severe in males, while the redox status changes are more severe in females; SAM corrects both. VPA-induced ASD seems to result from epigenetic changes, while the redox status changes may be secondary.
Source: Neurotoxicology and Teratology - Category: Toxicology Source Type: research