Co-use of tobacco and marijuana during pregnancy: Pathways to externalizing behavior problems in early childhood
Publication date: Available online 4 August 2018Source: Neurotoxicology and TeratologyAuthor(s): Stephanie A. Godleski, Shannon Shisler, Rina D. Eiden, Marilyn A. HuestisAbstractUse and co-use of tobacco and marijuana during pregnancy are associated with the development of social, cognitive, and behavioral problems for infants and children. However, less is known about the potential developmental impact of the use of tobacco and marijuana in tandem. The present study examined an etiological model for the development of externalizing behavior problems (EBP) in early childhood in a high risk sample (N = 247) of mother-in...
Source: Neurotoxicology and Teratology - August 4, 2018 Category: Toxicology Source Type: research
Metabolomics studies on corticosterone-induced PC12 cells: A strategy for evaluating an in vitro depression model and revealing the metabolic regulation mechanism
Publication date: Available online 1 August 2018Source: Neurotoxicology and TeratologyAuthor(s): Jun-sheng Tian, Shao-bo Liu, Xiao-yan He, Huan Xiang, Jian-li Chen, Yao Gao, Yu-zhi Zhou, Xue-mei QinAbstractThere are three types of differentiated (un-, poorly- and well-differentiated) PC12 cells, which have been widely used as a model system for depression studies after the administration of corticosterone (CORT). In order to investigate the underlying metabolic profiles of CORT-induced PC12 cells and evaluate the suitable differentiated types of PC12 cells for use in depressive studies, proton nuclear magnetic resonance (1...
Source: Neurotoxicology and Teratology - August 2, 2018 Category: Toxicology Source Type: research
Editorial Board
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 17, 2018 Category: Toxicology Source Type: research
Comparison of neurotoxicity of dexmedetomidine as an adjuvant in brachial plexus block in rats of different age
Publication date: Available online 11 July 2018Source: Neurotoxicology and TeratologyAuthor(s): Zhenming Kang, Wenji Xie, Wenqin Xie, Shunyuan Li, Rushuang ChenAbstractDexmedetomidine is a local anesthetic adjuvant that exerts neuroprotective effects in addition to its sedative and analgesic properties. However, it is not clear whether dexmedetomidine causes any neurotoxicity in neonates. We injected dexmedetomidine alone or in combination with ropivacaine to induce brachial plexus block in rats of different age, corresponding to human neonate, childhood, adolescence and adulthood. We then examined pro-inflammatory cytokin...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides
Publication date: Available online 31 October 2017Source: Neurotoxicology and TeratologyAuthor(s): Holly Richendrfer, Robbert CretonAbstractAntidepressants are used by a substantial number of women in their childbearing years. Treatment may continue during pregnancy, since untreated depression poses a risk to the mother and child. However, many antidepressants readily pass through the placental barrier to reach the fetus or may be ingested by the newborn via breastmilk. Little is known about the effects of antidepressants on brain development and subsequent behavior in young children. In the current study, we used zebrafis...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos
This study offers evidence for a potential mechanism by which ketamine could cause ATP deficiency mediated by mitochondrial dysfunction. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Corrigendum to “Neonatal inhibition of Na+-K+-2Cl−-cotransporter prevents ketamine induced spatial learning and memory impairments” [Neurotoxicol. Teratol. 60 (2017) 82–86]
Publication date: Available online 2 January 2018Source: Neurotoxicology and TeratologyAuthor(s): Ryan A. Stevens, Brandon D. Butler, Saurabh S. Kokane, Andrew W. Womack, Qing Lin (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice
ConclusionsEarly postnatal VPA administration induces ASD like behavior that is more severe in males, while the redox status changes are more severe in females; SAM corrects both. VPA-induced ASD seems to result from epigenetic changes, while the redox status changes may be secondary. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Prenatal substance exposure and offspring development: Does DNA methylation play a role?
Publication date: Available online 16 February 2018Source: Neurotoxicology and TeratologyAuthor(s): Valerie S. Knopik, Kristine Marceau, L. Cinnamon Bidwell, Emily RolanAbstractThe period of in utero development is one of the most critical windows during which adverse conditions and exposures may influence the growth and development of the fetus as well as its future postnatal health and behavior. Maternal substance use during pregnancy remains a relatively common but nonetheless hazardous in utero exposure. For example, previous epidemiological studies have associated prenatal substance exposure with reduced birth weight,...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: Genetic and epigenetic factors
Publication date: Available online 21 February 2018Source: Neurotoxicology and TeratologyAuthor(s): Hannah E. Lapp, Sarah Ahmed, Celia L. Moore, Richard G. HunterAbstractHistories of early life stress (ELS) or social discrimination can reach levels of severity characterized as toxic to mental and physical health. Such toxic social stress during development has been linked to altered acute hypothalamic-pituitary-adrenal (HPA) response to social stress in adulthood. However, there are important individual differences in the size and direction of these effects. We explored developmental, genetic, epigenetic, and contextual so...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
N-acetylcysteine inhibits Mancozeb-induced impairments to the normal development of zebrafish embryos
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): Dennis Guilherme da Costa-Silva, Luana Paganotto Leandro, Pratícia de Brum Vieira, Nelson Rodrigues de Carvalho, Andressa Rubim Lopes, Lucia Emanueli Schimith, Mauro Eugênio Medina Nunes, Renata Siqueira de Mello, Illana Kemmerich Martins, Adriano Alves de Paula, Andrés Delgado Cañedo, José Cláudio Fonseca Moreira, Thais Posser, Jeferson Luis FrancoAbstractMancozeb (MZ), a manganese/zinc-containing ethylene-bis-dithiocarbamate (EBCD) fungicide has been claimed to present low acute toxicity and short environmental persisten...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Neuroanatomical characteristics of youths with prenatal opioid and poly-drug exposure
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): Egil Nygaard, Kari Slinning, Vibeke Moe, Paulina Due-Tønnessen, Anders Fjell, Kristine B. WalhovdAbstractNeuroanatomical and cognitive differences have been documented during childhood between children with prenatal opioid- and poly-drug exposure and controls in small samples. We investigated whether these differences persisted in larger samples of youth at older ages. Quantitative MRI and cognitive data were compared between 38 youths in the risk group and 44 youths in the non-exposed group (aged 17 to 22 years) who had been...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Repeated toluene exposure increases the excitability of layer 5 pyramidal neurons in the prefrontal cortex of adolescent rats
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): Monserrat Armenta-Resendiz, Silvia L. Cruz, Emilio J. GalvánAbstractDespite serious health effects, volatile industrial products containing toluene are deliberately inhaled for their psychoactive actions, mainly among adolescents and young adults. Chronic toluene inhalation induces multiple alterations at the cellular and behavioral level; however, modifications of neuronal networks associated with the reward system after repeated toluene exposure are not thoroughly characterized. Here we used whole-cell recordings to determine...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Effects of low-level sarin and cyclosarin exposure on hippocampal microstructure in Gulf War Veterans
We examined fractional anisotropy (FA), mean diffusivity (MD), and grey matter (GM) density from a hippocampal region of interest (ROI). Results indicate that, even after accounting for total hippocampal GM density (or hippocampal volume), age, sex, apolipoprotein ε4 genotype, and potential confounding OP pesticide exposures, hippocampal MD significantly predicted Khamisiyah exposure status (model p = 0.005, R2 = 0.215, standardized coefficient β = 0.26, t = 2.85). Hippocampal MD was also inversely correlated with verbal memory learning performance in the entire study sample (p = 0.001). There were no...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
Prenatal exposure to tobacco and cannabis: Effects on autonomic and emotion regulation
We examined a conceptual model linking prenatal exposure to toddler regulation via these two pathways in a prospective sample (N = 247) of mother-child dyads recruited in the first trimester of pregnancy. Results indicated significant effects of co-exposure on poor autonomic regulation in infancy, which in turn predicted poor toddler emotion regulation. Mothers who used both tobacco and cannabis displayed lower sensitivity during play interactions with their infants. Maternal sensitivity was modestly stable from infant to toddler period and was predictive of higher toddler emotion regulation. Continued postnatal exposu...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research
