Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient
ConclusionOur data suggest that the effects of isoflurane on growth cone sensing are mediated by the α2 subunit of the GABAA receptor and also that they are dependent on the developmental chloride gradient, in which Cl− exhibits a depolarizing effect. These findings provide a rationale for why immature neurons are particularly susceptible to anesthetic toxicity. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - June 26, 2019 Category: Toxicology Source Type: research
Developmental neurotoxicity in the context of multiple sevoflurane exposures: Potential role of histone deacetylase 6
In conclusion, HDAC6 is involved in the developmental neurotoxicity caused by multiple sevoflurane exposures and its inhibition may prevent related damage. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - June 26, 2019 Category: Toxicology Source Type: research
Vitexin inhibits acrylamide-induced neuroinflammation and improves behavioral changes in zebrafish larvae
Publication date: Available online 31 May 2019Source: Neurotoxicology and TeratologyAuthor(s): Manigandan Krishnan, Sun Chul KangAbstractNeuroinflammation is crucial for the pathophysiological hallmarks of many neurodegenerative disorders. Hyperactivated microglia has long been implicated as a detrimental player in regulating unresolvable inflammatory insults which cause damage to neurons. In the context of acrylamide (ACR) neurotoxicity, microglia activation is documented to correlate with ACR-adduct formation in the presynaptic neurons. Thus, inhibition of inflammatory mediators through vital candidate is greatly warrant...
Source: Neurotoxicology and Teratology - June 1, 2019 Category: Toxicology Source Type: research
Prenatal and recent methylmercury exposure and heart rate variability in young adults: the Seychelles Child Development Study
In conclusion, prenatal and recent MeHg exposure had no consistent pattern of associations to support the hypothesis that they are adversely associated with heart rate variability in this study population that consumes large amounts of fish. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 25, 2019 Category: Toxicology Source Type: research
Sub-lethal effects of the triazole fungicide propiconazole on zebrafish (Danio rerio) development, oxidative respiration, and larval locomotor activity
This study demonstrates that propiconazole can induce hypopigmentation in zebrafish, disrupts mitochondrial bioenergetics, and alters locomotor activity. However, these sub-lethal responses were observed at concentrations above what is typically detected in the environment. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 23, 2019 Category: Toxicology Source Type: research
Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring
Publication date: Available online 16 May 2019Source: Neurotoxicology and TeratologyAuthor(s): Andrew B. Hawkey, Hannah White, Erica Pippen, Eva Greengrove, Amir H. Rezvani, Susan K. Murphy, Edward D. LevinAbstractStudies of intergenerational effects of parental chemical exposure have principally focused on maternal exposure, particularly for studies of adverse neurobehavioral consequences on the offspring. Maternal nicotine exposure has long been known to cause adverse neurobehavioral effects on the offspring. However, paternal toxicant exposure has also been found to cause neurobehavioral toxicity in their offspring. Rec...
Source: Neurotoxicology and Teratology - May 17, 2019 Category: Toxicology Source Type: research
Editorial Board
Publication date: May–June 2019Source: Neurotoxicology and Teratology, Volume 73Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 10, 2019 Category: Toxicology Source Type: research
Co-use of tobacco and marijuana during pregnancy: Impact on nervous system development
Publication date: Available online 3 May 2019Source: Neurotoxicology and TeratologyAuthor(s): Natacha M. De Genna, Laura R. Stroud, Rina D. Eiden (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 4, 2019 Category: Toxicology Source Type: research
Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring
This study shows that premating paternal THC exposure even at a modest dose for a brief period can cause deleterious long-term behavioral effects in the offspring, notably significant impairment in an operant attention task. Further research should be conducted to determine the degree to which this type of risk is seen in humans and to investigate the mechanisms underlying these effects and possible treatments to ameliorate these long-term adverse behavioral consequences of paternal THC exposure. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - April 25, 2019 Category: Toxicology Source Type: research
Comparative analyses of the neurobehavioral, molecular, and enzymatic effects of organophosphates on embryo-larval zebrafish (Danio rerio)
Publication date: Available online 9 April 2019Source: Neurotoxicology and TeratologyAuthor(s): Cassandra Schmitt, Michelle McManus, Naveen Kumar, Olushola Awoyemi, Jordan CragoAbstractOrganophosphates insecticides (OPs) are common surface water contaminants in both urban and agricultural landscapes. Neurobehavioral effects on larval fish are known to occur at concentrations higher than those reported in the environment. The aim of this study was to perform a comparative analysis of neurobehavioral, molecular, and biochemical responses of four OPs (diazinon, dichlorvos, malathion, methyl-parathion) via the following endpoi...
Source: Neurotoxicology and Teratology - April 10, 2019 Category: Toxicology Source Type: research
43rd Annual Meeting of the Developmental Neurotoxicology Society: Held in Conjunction with the 59th Annual Meeting of the Teratology Society and 32nd Annual Education Meeting for the Organization of Teratology Information Specialists, Sheraton San Diego Hotel and Marina, San Diego, CA, June 23–26, 2019
Publication date: Available online 5 April 2019Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - April 5, 2019 Category: Toxicology Source Type: research
Altered motor development following late gestational alcohol and cannabinoid exposure in rats
Publication date: Available online 31 March 2019Source: Neurotoxicology and TeratologyAuthor(s): Kristen R. Breit, Brandonn Zamudio, Jennifer D. ThomasAbstractCannabis is the most commonly used illicit drug among pregnant women, and rates are likely to increase given recent legalization. In addition, half of pregnant women who report consuming cannabis also report drinking alcohol. However, little is known about the consequences of prenatal cannabis alone or combination with alcohol, particularly with cannabis products that are continually increasing in potency of the primary psychoactive constituent in cannabis, Δ9-tetra...
Source: Neurotoxicology and Teratology - April 2, 2019 Category: Toxicology Source Type: research
Analgesic and toxic effects of venenum bufonis and its constituent compound cinobufagin: A comparative study
ConclusionsBoth VB and CBG exhibited analgesic effects and low hemolytic toxicity; however, the latter showed stronger analgesic activity and less hepatotoxicity. Additionally, both VB and CBG increased the heart rate; however, CBG had stronger effects and higher acute toxicity. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 31, 2019 Category: Toxicology Source Type: research
Screening for neurotoxic potential of 15 flame retardants using freshwater planarians
In this study, we used our automated planarian screening platform to compare the neurotoxicity of 15 flame retardants (FRs), consisting of representative phased-out brominated (BFRs) and replacement organophosphorus FRs (OPFRs). OPFRs have emerged as a proposed safer alternative to BFRs; however, limited information is available on their health effects. We found 11 of the 15 FRs (3/6 BFRs, 7/8 OPFRs, and Firemaster 550) caused adverse effects in both adult and developing planarians with similar nominal lowest-effect-levels for BFRs and OPFRs. This suggests that replacement OPFRs are comparably neurotoxic to the phased-out ...
Source: Neurotoxicology and Teratology - March 31, 2019 Category: Toxicology Source Type: research
Associations of first trimester co-use of tobacco and Cannabis with prenatal immune response and psychosocial well-being
ConclusionPreliminary results suggest women co-using during the first trimester exhibit decreased pro-inflammatory immune responsivity on one out of eight markers. Further research is needed to determine the impact of this immune modulation on fetal health outcomes and the unique contribution of cannabis. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 30, 2019 Category: Toxicology Source Type: research
